公开(公告)号：US20130228002A1

公开(公告)日：2013-09-05

申请号：US13864936

申请日：2013-04-17

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： James R. Petisce ,  Michael Higgins ,  Kristie P. Trinh ,  Todd Abraham

IPC: G01N33/96

CPC classification number: G01N33/96 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/4839 ,  A61M2207/00 ,  A61M2230/201 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/104998 ,  Y10T436/108331

Abstract: Methods and systems for preparation of calibrant infusion fluid sources are disclosed. In one embodiment, a precise volume of glucose is injected into a saline-solution filled calibrant infusion fluid source proximate in time to conducting a calibration procedure. The glucose concentration in the calibrant infusion fluid source is subsequently calculated based on the measured weight of the saline-solution, as determined prior to glucose injection, and the volume of glucose injected. This method provides a highly accurate and convenient manner for use in a hospital environment, for example, with an intravenous blood glucose sensor system. In another embodiment, a premixed calibrant infusion fluid source is provided that includes saline solution and a predetermined concentration of glucose. In such embodiments, shelf life problems related to water evaporation are mitigated by hermetically covering or otherwise hermetically containing the calibrant infusion fluid source up until the point of use.

Abstract translation: 公开了用于制备校准液输注液源的方法和系统。 在一个实施方案中，在时间上将精确体积的葡萄糖注入盐水溶液填充的校准液输注液源中以进行校准程序。 随后根据在注射葡萄糖之前测定的盐水溶液的测量重量和注入的葡萄糖体积来计算校准液输注液源中的葡萄糖浓度。 该方法提供了在医院环境中使用的高度准确和方便的方式，例如使用静脉内血糖传感器系统。 在另一个实施方案中，提供了预混合的校准液输注液源，其包括盐溶液和预定浓度的葡萄糖。 在这样的实施方案中，通过气密地覆盖或以其他方式密封含有校准液输注流体源直到使用点来减轻与水蒸发相关的保质期问题。