公开(公告)号：US20090012595A1

公开(公告)日：2009-01-08

申请号：US10582847

申请日：2004-12-15

Applicant: Dror Seliktar ,  Rafael Beyar

Inventor： Dror Seliktar ,  Rafael Beyar

IPC: A61F2/82 ,  A61K38/18 ,  A61F2/92 ,  A61F2/84 ,  C08L89/00 ,  C08L1/00

CPC classification number: A61K47/36 ,  A61F2/07 ,  A61F2/92 ,  A61F2002/075 ,  A61F2002/30064 ,  A61F2250/0067 ,  A61F2310/0097 ,  A61K9/06 ,  A61K9/7007 ,  A61K47/10 ,  A61L31/06 ,  A61L31/16 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/426 ,  C08L71/02

Abstract: The present invention is of methods of preventing restenosis and promoting vascular re-healing. Specifically, the present invention is of a method of exposing the luminal wall of a blood vessel to a substance by deploying a drug-eluting polymer film inside the lumen of a blood vessel during or following angioplasty.

Abstract translation: 本发明是预防再狭窄和促进血管再愈合的方法。 具体地，本发明是通过在血管成形术期间或之后将药物洗脱聚合物膜展开在血管内腔内部而将血管的腔壁暴露于物质的方法。

公开(公告)号：US08257302B2

公开(公告)日：2012-09-04

申请号：US11920209

申请日：2005-05-10

Applicant: Rafael Beyar ,  Doron Linder ,  Eyal Zilberberg ,  Tal Wenderow

Inventor： Rafael Beyar ,  Doron Linder ,  Eyal Zilberberg ,  Tal Wenderow

IPC: A61M31/00 ,  A61B1/00

CPC classification number: A61B90/11 ,  A61B34/77 ,  A61B2017/00207 ,  A61B2034/301 ,  A61B2034/742 ,  A61B2090/064 ,  A61M25/0133

Abstract: A remote control catheterization system comprising: a propelling device, which controllably inserts a flexible, elongate probe into the body of a patient; and a control unit, in communication with the propelling device, and comprising user controls which are operated by a user of the system remote from the patient to control insertion of the probe into the body by the propelling device, wherein the user controls include an intuitive user interface comprising a handle that can be moved longitudinally, forward and back along a longitudinal axis, and also can be moved rotationally, in rotation around the longitudinal axis; the intuitive user interface comprising motion sensors that detect longitudinal motion and rotational motion of the handle and convert them to signals; and signal communication circuitry that communicates the signals to the control unit for commanding the propelling device to move the probe in respective direction and distance as the handle.

Abstract translation: 一种遥控导管系统，包括：推进装置，其可控制地将柔性细长的探针插入患者体内; 以及与所述推进装置通信的控制单元，并且包括由远离患者的系统的用户操作以控制通过推进装置将探针插入身体的用户控制，其中，用户控制包括直观的 用户界面包括可以沿着纵向轴线纵向，前后移动的手柄，并且还可以围绕纵向轴线旋转地旋转移动; 直观的用户界面包括运动传感器，其检测手柄的纵向运动和旋转运动并将其转换成信号; 以及信号通信电路，其将信号传送到控制单元，用于指令推进装置在相应的方向和距离上移动探针作为手柄。

公开(公告)号：US06402777B1

公开(公告)日：2002-06-11

申请号：US09643393

申请日：2000-08-22

Applicant: Oren Globerman ,  Mordechay Beyar ,  Rafael Beyar

Inventor： Oren Globerman ,  Mordechay Beyar ,  Rafael Beyar

IPC: A61F206

CPC classification number: A61F2/915 ,  A61B90/39 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91583 ,  A61F2240/001 ,  A61F2250/0098

Abstract: Stents which are inserted into a body lumen preferably are made of materials which are not radiopaque enough, such as S.S. 316L. X-ray visualization of a stent enables an accurate positioning of the stent and also a follow-up of its functioning within the patient's body. The radiopaque markers described here are rivets made of a material which is more radiopaque than the stent substance so the location of the stent can be identified.

Abstract translation: 插入体腔的支架优选由不透射线不足的材料制成，例如S.S. 316L。 支架的X射线可视化使得支架的精确定位以及其在患者体内的功能的随访。 这里描述的不透射线标记是由比支架物质更不透射线的材料制成的铆钉，因此可以识别支架的位置。

公开(公告)号：US07615042B2

公开(公告)日：2009-11-10

申请号：US10561147

申请日：2005-05-10

Applicant: Rafael Beyar ,  Tal Wenderow ,  Doron Linder ,  Eyal Zilberberg

Inventor： Rafael Beyar ,  Tal Wenderow ,  Doron Linder ,  Eyal Zilberberg

IPC: A61M31/00

CPC classification number: A61M25/0113 ,  A61B2034/301

Abstract: An apparatus for imparting motion from at least one of a plurality of motion sources into linear, rotary, or combined linear and rotary motion of an elongated device, the apparatus comprising a transmission for translating the motion to linear or rotary motion of the elongated device.

Abstract translation: 一种用于将来自多个运动源中的至少一个的运动传递到细长装置的线性，旋转或组合的线性和旋转运动的装置，所述装置包括用于将运动转换为细长装置的线性或旋转运动的传动装置。

公开(公告)号：US20090221958A1

公开(公告)日：2009-09-03

申请号：US11920209

申请日：2005-05-10

Applicant: Rafael Beyar ,  Doron Linder ,  Eyal Zilberberg ,  Tal Wenderow

Inventor： Rafael Beyar ,  Doron Linder ,  Eyal Zilberberg ,  Tal Wenderow

IPC: A61M25/092 ,  A61F2/84

CPC classification number: A61B90/11 ,  A61B34/77 ,  A61B2017/00207 ,  A61B2034/301 ,  A61B2034/742 ,  A61B2090/064 ,  A61M25/0133

Abstract: A remote control catheterization system comprising: a propelling device, which controllably inserts a flexible, elongate probe into the body of a patient; and a control unit, in communication with the propelling device, and comprising user controls which are operated by a user of the system remote from the patient to control insertion of the probe into the body by the propelling device, wherein the user controls include an intuitive user interface comprising a handle that can be moved longitudinally, forward and back along a longitudinal axis, and also can be moved rotationally, in rotation around the longitudinal axis; the intuitive user interface comprising motion sensors that detect longitudinal motion and rotational motion of the handle and convert them to signals; and signal communication circuitry that communicates the signals to the control unit for commanding the propelling device to move the probe in respective direction and distance as the handle.

Abstract translation: 一种遥控导管系统，包括：推进装置，其可控制地将柔性细长的探针插入患者体内; 以及与所述推进装置通信的控制单元，并且包括由远离患者的系统的用户操作以控制通过推进装置将探针插入身体的用户控制，其中，用户控制包括直观的 用户界面包括可以沿着纵向轴线纵向，前后移动的手柄，并且还可以围绕纵向轴线旋转地旋转移动; 直观的用户界面包括运动传感器，其检测手柄的纵向运动和旋转运动并将其转换成信号; 以及信号通信电路，其将信号传送到控制单元，用于指令推进装置在相应的方向和距离上移动探针作为手柄。

公开(公告)号：US6090115A

公开(公告)日：2000-07-18

申请号：US136249

申请日：1998-08-19

Applicant: Rafael Beyar ,  Oren Globerman ,  Mordechay Beyar

Inventor： Rafael Beyar ,  Oren Globerman ,  Mordechay Beyar

IPC: A61B17/12 ,  A61F2/00 ,  A61F2/06 ,  A61F2/84 ,  A61F2/88 ,  A61B17/00

CPC classification number: A61F2/88 ,  A61F2/95 ,  A61B2017/1205 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2250/0059

Abstract: This application is directed to a stent delivery system for introducing a flexible, generally cylindrical, self-expandable stent. The system comprises a catheter having distal and proximal ends, the catheter defining at least one lumen extending therethrough and having at least three longitudinally displaced openings or sets of openings extending from a lumen to the surface of the catheter; a stent which comprises a generally cylindrical, expandable structure having proximal and distal ends and a flexible member extending proximally from the proximal end of the structure, the stent being wound circumferentially around the catheter, and having restraining members holding each of the proximal and distal ends of the stent to the catheter, and one or more restraining members holding at least a portion of the flexible member to the catheter surface; and one or two release wires positioned in and extending longitudinally through at least one lumen, the release wires cooperating with the restraining members so that as the release wire or wires are withdrawn proximally, the proximal and distal end sections of the stent are released in such a manner that coils of the stent unwind.

Abstract translation: 本申请涉及一种用于引入柔性的，大致圆柱形的自扩张支架的支架输送系统。 所述系统包括具有远端和近端的导管，所述导管限定延伸穿过其中的至少一个内腔，并且具有至少三个纵向移位的开口或一组开口，其从内腔延伸到导管的表面; 支架，其包括具有近端和远端的大致圆柱形的可扩张结构，以及从所述结构的近端向近侧延伸的柔性构件，所述支架围绕所述导管周向缠绕，并且具有保持每个所述近端和远端的约束构件 以及一个或多个限制构件，其将所述柔性构件的至少一部分保持在所述导管表面上; 以及一个或两个释放线定位在纵向延伸穿过至少一个内腔，所述释放线与限制构件协作，使得当释放线或线在近侧被拉出时，支架的近端部分和远端部分以这样的方式释放 支架放卷的方式。

公开(公告)号：US20090131955A1

公开(公告)日：2009-05-21

申请号：US12088665

申请日：2005-09-29

Applicant: Tal Wenderow ,  Rafael Beyar

Inventor： Tal Wenderow ,  Rafael Beyar

IPC: A61B19/00

CPC classification number: A61B34/20 ,  A61B34/70 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2034/107 ,  A61B2090/376

Abstract: An apparatus for treating a lumen, comprising: at least one mapping tool, wherein the at least one mapping tool is adapted and constructed to provide at least a partial map of an internal surface of the lumen; a display, adapted and constructed to permit the identification of at least one point of interest in the lumen, using the at least partial map; at least one sensor, wherein data retrieved from the at least one sensor is compared to the at least partial map for navigating at least one procedural instrument within the lumen; and, wherein treatment by the at least one procedural instrument occurs when sensed data compared with the at least partial map indicates the that least one procedural instrument is at at least one point of interest. In some exemplary embodiments of the invention, treatment is performed from a remote location in relation to the patient. Optionally, a propulsion apparatus navigates at least one procedural instrument in a lumen in response to commands from a controller.

Abstract translation: 一种用于处理内腔的装置，包括：至少一个映射工具，其中所述至少一个映射工具被适配和构造成提供所述内腔的内表面的至少部分图; 使用所述至少部分图来适配和构造为允许识别所述管腔中的至少一个兴趣点的显示器; 至少一个传感器，其中从所述至少一个传感器检索的数据与所述至少部分图比较，用于导航所述管腔内的至少一个程序性仪器; 并且其中当所述至少一个程序性仪器处于至少一个兴趣点时，所述至少一个程序性仪器的检测与所述至少部分图谱相比较时发生。 在本发明的一些示例性实施例中，相对于患者从远程位置执行治疗。 可选地，推进装置响应于来自控制器的命令，导航管腔中的至少一个程序仪器。

公开(公告)号：US20080217564A1

公开(公告)日：2008-09-11

申请号：US11715876

申请日：2007-03-09

Applicant: Rafael Beyar ,  Tal Wenderow ,  Moshe DePaz

Inventor： Rafael Beyar ,  Tal Wenderow ,  Moshe DePaz

IPC: G21F3/00

CPC classification number: G08C19/16 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61B6/462 ,  A61B6/467

Abstract: An apparatus for control of a procedure, comprising: a communications interface; a control console, wherein the control console is adapted to provide control commands via the communications interface to at least one of: at least one imaging device or at least one medical instrument used to perform the procedure; and, at least one radiation shield attached to the control console and positioned between the control console and a patient on which the procedure is being performed, wherein the apparatus is separately movable from at least one of the at least one imaging device, the patient or the at least one medical instrument.

Abstract translation: 一种用于控制程序的装置，包括：通信接口; 控制台，其中所述控制台适于通过所述通信接口向至少一个成像设备或用于执行所述过程的至少一个医疗仪器中的至少一个提供控制命令; 以及至少一个辐射屏蔽件，其附接到所述控制台并且定位在所述控制台与正在执行所述过程的患者之间，其中所述设备可从所述至少一个成像装置，所述患者或所述至少一个成像装置， 至少一个医疗器械。

公开(公告)号：US06371953B1

公开(公告)日：2002-04-16

申请号：US09551479

申请日：2000-04-18

Applicant: Rafael Beyar ,  Oren Globerman ,  Mordechay Beyar

Inventor： Rafael Beyar ,  Oren Globerman ,  Mordechay Beyar

IPC: A61M2900

CPC classification number: A61F2/88 ,  A61B2017/1205 ,  A61F2/95 ,  A61F2002/9505 ,  A61F2002/9511 ,  A61F2250/0059

Abstract: This application is directed to a stent delivery system for introducing a flexible, generally cylindrical, self-expandable stent. The system comprises a catheter having distal and proximal ends, the catheter defining at least one lumen extending therethrough and having at least three longitudinally displaced openings or sets of openings extending from a lumen to the surface of the catheter; a stent which comprises a generally cylindrical, expandable structure having proximal and distal ends and a flexible member extending proximally from the proximal end of the structure, the stent being wound circumferentially around the catheter, and having restraining means holding each of the proximal and distal ends of the stent to the catheter, and one or more restraining means holding at least a portion of the flexible member to the catheter surface; and one or two release wires positioned in and extending longitudinally through at least one lumen, the release wires cooperating with the restraining means so that as the release wire or wires are withdrawn proximally, the proximal and distal end sections of the stent are released in such a manner that coils of the stent unwind.

Abstract translation: 本申请涉及用于引入柔性的，大致圆柱形的自扩张支架的支架输送系统。 所述系统包括具有远端和近端的导管，所述导管限定延伸穿过其中的至少一个内腔，并且具有至少三个纵向移位的开口或一组开口，其从内腔延伸到导管的表面; 支架，其包括具有近端和远端的大致圆柱形的可扩张结构，以及从所述结构的近端向近侧延伸的柔性构件，所述支架围绕导管周向地缠绕，并且具有保持每个近端和远端的约束装置 以及将至少一部分柔性构件保持在导管表面上的一个或多个约束装置; 和一个或两个释放线定位在纵向延伸穿过至少一个内腔，释放线与限制装置配合，使得随着释放线或线在近侧被撤回，支架的近端部分和远端部分以这样的方式释放 支架放卷的方式。

公开(公告)号：US06334871B1

公开(公告)日：2002-01-01

申请号：US08697989

申请日：1996-09-03

Applicant: Ofer Dor ,  Amir Loshakove ,  Oren Globerman ,  Mordechay Beyar ,  Rafael Beyar

Inventor： Ofer Dor ,  Amir Loshakove ,  Oren Globerman ,  Mordechay Beyar ,  Rafael Beyar

IPC: A61F206

CPC classification number: A61F2/915 ,  A61B90/39 ,  A61F2/91 ,  A61F2002/91583 ,  A61F2230/0013 ,  A61F2240/001 ,  A61F2250/0098

Abstract: Stents which are inserted into a body lumen preferably are made of materials which are not radiopaque enough, such as stainless steel 316L. X-ray visualization of a stent enables an accurate positioning of the stent and also a follow-up of its functioning within the patient's body. The radiopaque markers described here are rivets made of a material which is more radiopaque than the stent substance so the location of the stent can be identified. Preferably the stents are heat treated so that atoms from the stent material migrate into the marker material and vice versa.

Abstract translation: 插入体腔的支架优选由不能不透射线的材料制成，例如不锈钢316L。 支架的X射线可视化使得支架的精确定位以及其在患者体内的功能的随访。 这里描述的不透射线标记是由比支架物质更不透射线的材料制成的铆钉，因此可以识别支架的位置。 优选地，支架被热处理，使得来自支架材料的原子迁移到标记材料中，反之亦然。