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公开(公告)号：US08790889B2
公开(公告)日：2014-07-29
申请号：US13518234
申请日：2010-12-21
Applicant: Dhanisha Jhaveri , Perry Francis Bartlett
Inventor： Dhanisha Jhaveri , Perry Francis Bartlett
CPC classification number: A61K35/30 , C12N5/0623 , C12N2501/80 , C12N2501/825
Abstract: A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a β3 adrenergic receptor agonist.
Abstract translation: 一种激活潜在神经前体细胞群的方法，包括：（1）提供衍生自海马的神经细胞群; （2）将神经细胞群导入神经球形成培养基中; 和（3）通过用β-肾上腺素能受体激动剂治疗来激活潜在前体细胞群体。
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公开(公告)号：US20130004984A1
公开(公告)日：2013-01-03
申请号：US13518234
申请日：2010-12-21
Applicant: Dhanisha Jhaveri , Perry Francis Bartlett
Inventor： Dhanisha Jhaveri , Perry Francis Bartlett
CPC classification number: A61K35/30 , C12N5/0623 , C12N2501/80 , C12N2501/825
Abstract: A method of activating a latent neural precursor cell population, comprising: (1) providing a neural cell population derived from the hippocampus; (2) introducing the neural cell population to a neurosphere-forming culture medium; and (3) activating the latent precursor cell population by treatment with a β3 adrenergic receptor agonist.
Abstract translation: 一种激活潜在神经前体细胞群的方法，包括：（1）提供衍生自海马的神经细胞群; （2）将神经细胞群导入神经球形成培养基中; 和（3）通过用β-肾上腺素能受体激动剂治疗来激活潜在前体细胞群体。
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公开(公告)号：US07919471B2
公开(公告)日：2011-04-05
申请号：US10921065
申请日：2004-08-18
Applicant: Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
Inventor： Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
IPC: A61K48/00
CPC classification number: C07K14/70571 , A61K38/00 , A61K48/00
Abstract: The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins s well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.
Abstract translation: 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。
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Patent Agency Ranking
公开(公告)号：US20120195860A1
公开(公告)日：2012-08-02
申请号：US12595220
申请日：2008-04-10
Applicant: Tara Louise Walker , Perry Francis Bartlett
Inventor： Tara Louise Walker , Perry Francis Bartlett
IPC: A61K35/30 , A61K33/14 , C12N13/00 , A61N2/00 , G01N21/64 , A61P25/28 , A61N1/36 , C12N5/0797 , C12Q1/02
CPC classification number: C12N5/0623 , A61K33/00 , A61K33/14 , A61K35/12 , A61N1/205 , A61N1/326 , A61N1/36014 , C12N2500/05
Abstract: The present invention relates to a latent neural stem cell population which is capable of activation by membrane depolarization of a neural cell population, isolation and culture of same, and uses thereof.
Abstract translation: 本发明涉及能够通过神经细胞群的膜去极化活化，其分离和培养及其用途的潜神经干细胞群。
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公开(公告)号：US07435586B2
公开(公告)日：2008-10-14
申请号：US10479306
申请日：2002-05-31
Applicant: Perry Francis Bartlett , Rodney Lee Rietze
Inventor： Perry Francis Bartlett , Rodney Lee Rietze
CPC classification number: A61K35/30 , C12N5/0623
Abstract: The present invention relates generally to a method for the generation of a substantially homogeneous population of undifferentiated cells. More particularly, the present invention relates to the purification of a substantially homogeneous population of stem cells and their progenitor or precursor cells. Even more particularly, the present invention provides a population of neural stem cells (NSCs). The subject invention is particularly directed to NSCs and precursor cells with the capacity to differentiate into cells and cell lineages required for the development, maintenance or repair of the central nervous system in an animal such as a mammal. The present invention is further directed to NSCs and progenitor and/or precursor cells which are capable of proliferation and differentiation into multiple cell lineages, such as but not limited to neurons, oligodendrocytes, glia and astrocytes. The subject invention further contemplates the use of NSCs and/or precursor cells for the repair or regeneration of tissue, such as tissue associated with the central nervous system, in an animal including a mammal. The NSCs of the present invention may be used to identify naturally occurring molecules such as cytokines as well as molecules obtained from natural product screening or screening of chemical libraries which induce proliferation of the NSCs. Such molecules are useful in the development of therapeutics.
Abstract translation: 本发明一般涉及产生基本上同质的未分化细胞群的方法。 更具体地，本发明涉及纯化基本上同质的干细胞群及其祖细胞或前体细胞。 更具体地说，本发明提供了一组神经干细胞（NSCs）。 本发明特别涉及具有分化为动物如哺乳动物的中枢神经系统的发育，维持或修复所需的细胞和细胞谱系的能力的神经干细胞和前体细胞。 本发明还涉及能够增殖和分化成多种细胞谱系的神经干细胞和祖细胞和/或前体细胞，所述多种细胞谱系例如但不限于神经元，少突胶质细胞，神经胶质细胞和星形胶质细胞。 本发明还考虑在包括哺乳动物的动物中使用NSCs和/或前体细胞来修复或再生组织，例如与中枢神经系统相关的组织。 本发明的NSCs可用于鉴定天然存在的分子，例如细胞因子以及从天然产物筛选或筛选诱导NSCs增殖的化学文库获得的分子。 这样的分子可用于治疗学的发展。
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公开(公告)号：US09890358B2
公开(公告)日：2018-02-13
申请号：US12595220
申请日：2008-04-10
Applicant: Tara Louise Walker , Perry Francis Bartlett
Inventor： Tara Louise Walker , Perry Francis Bartlett
IPC: A61N2/00 , A61K35/30 , C12Q1/02 , A61P25/28 , G01N21/64 , A61K33/14 , C12N13/00 , C12N5/0797 , A61N1/36 , A61K33/00 , A61K35/12 , A61N1/20 , A61N1/32
CPC classification number: C12N5/0623 , A61K33/00 , A61K33/14 , A61K35/12 , A61N1/205 , A61N1/326 , A61N1/36014 , C12N2500/05
Abstract: The present invention relates to a latent neural stem cell population which is capable of activation by membrane depolarization of a neural cell population, isolation and culture of same, and uses thereof.
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公开(公告)号：US08299027B2
公开(公告)日：2012-10-30
申请号：US12885194
申请日：2010-09-17
Applicant: Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
Inventor： Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
IPC: A61K38/18
CPC classification number: C07K14/70571 , A61K38/00 , A61K48/00
Abstract: The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.
Abstract translation: 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。
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公开(公告)号：US20110172143A1
公开(公告)日：2011-07-14
申请号：US12885194
申请日：2010-09-17
Applicant: Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
Inventor： Perry Francis Bartlett , Elizabeth Jane Coulson , Katrina Fieldew , Manuel Baca , Trevor Kilpatrick , Cheema Surindar
IPC: A61K38/00 , A61K38/16 , A61P25/28 , A61P25/00 , A61P25/02 , A61P13/12 , A61P31/22 , A61P25/16 , A61P35/00 , A61P31/12 , A61P31/18
CPC classification number: C07K14/70571 , A61K38/00 , A61K48/00
Abstract: The present invention relates generally to a method for modulating cell survival. Modulation of cell survival includes inducing, enhancing or otherwise promoting cell survival such as the survival of neural cells as well as facilitating cell death such as the death of targeted cancer cells. The modulation of cell survival is mediated by a region identified on the p75 neurotrophin receptor (p75NTR) required for death signalling. The present invention further provides genetic molecules which encode the death signalling region of p75NTR which are useful in antagonising death signal function as well as promoting cell death when expressed in targeted cells. The present invention also contemplates recombinant peptides, polypeptides and proteins as well as chemical equivalents, derivatives and homologues thereof which comprise the death signalling portion of p75NTR. Particularly useful molecules of the present invention comprise peptides corresponding to soluble forms of the death signalling portion of p75NTR. These molecules antagonise p75NTR-mediated cell death.
Abstract translation: 本发明一般涉及调节细胞存活的方法。 细胞存活的调节包括诱导，增强或以其他方式促进细胞存活，例如神经细胞的存活以及促进细胞死亡，例如靶向癌细胞的死亡。 细胞存活的调节由死亡信号传导所需的p75神经营养因子受体（p75NTR）鉴定的区域介导。 本发明还提供编码p75NTR的死亡信号传导区的遗传分子，其可用于拮抗死亡信号功能以及当在靶细胞中表达时促进细胞死亡。 本发明还考虑了重组肽，多肽和蛋白质以及其包含p75NTR的死亡信号传导部分的化学等同物，衍生物和同系物。 本发明特别有用的分子包含对应于p75NTR的死亡信号传导部分的可溶形式的肽。 这些分子拮抗p75NTR介导的细胞死亡。
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