公开(公告)号：US11992312B2

公开(公告)日：2024-05-28

申请号：US17342071

申请日：2021-06-08

申请人： DexCom, Inc.

发明人： Peter C. Simpson ,  Minglian Shi ,  Sebastian Bohm ,  Maria Noel Brown Wells ,  John Patrick Majewski ,  Leah Morta Edra ,  Disha B. Sheth ,  John Michael Gray ,  Shanger Wang ,  Ted Tang Lee ,  Michael L. Moore ,  Jason Mitchell ,  Jennifer Blackwell ,  Neel Narayan Shah ,  Todd Andrew Newhouse ,  Jason Halac ,  Ryan Everett Schoonmaker ,  Paul V. Neale ,  Jiong Zou ,  Sean T. Saint

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486

CPC分类号： A61B5/14532 ,  A61B5/14503 ,  A61B5/683 ,  A61B5/6833 ,  A61B5/0004 ,  A61B5/0015 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6849 ,  A61B2560/045

摘要： Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

公开(公告)号：US20230328893A1

公开(公告)日：2023-10-12

申请号：US18205365

申请日：2023-06-02

申请人： DexCom, Inc.

发明人： Jason M. Halac ,  John Charles Barry ,  Becky L. Clark ,  Chris W. Dring ,  John Michael Gray ,  Kris Elliot Higley ,  Jeff Jackson ,  David A. Keller ,  Ted Tang Lee ,  Jason Mitchell ,  Kenneth Pirondini ,  David Rego ,  Ryan Everett Schoonmaker ,  Peter C. Simpson ,  Craig Thomas Gadd ,  Kyle Thomas Stewart ,  John Stanley Hayes

IPC分类号： H05K3/32 ,  A61B5/1486 ,  A61B5/145 ,  G01N27/327 ,  A61B5/1495 ,  A61B5/00 ,  A61M15/00 ,  G16H20/17 ,  G16H40/63 ,  A61M5/142 ,  A61M5/172 ,  A61M5/20 ,  A61M11/00 ,  A61M35/00 ,  A61B5/1459 ,  A61B5/1473

CPC分类号： H05K3/321 ,  A61M5/003 ,  A61B5/14532 ,  G01N27/3273 ,  A61B5/1495 ,  A61B5/6849 ,  A61M15/0068 ,  A61M15/008 ,  A61M15/0083 ,  G16H20/17 ,  G16H40/63 ,  A61B5/14546 ,  A61M5/14244 ,  A61M5/14276 ,  A61M5/1723 ,  A61M5/20 ,  A61M11/00 ,  A61M15/0065 ,  A61M35/00 ,  G01N27/3274 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/6801 ,  A61B2562/085 ,  A61B2562/12 ,  A61B2562/08 ,  A61B5/0031 ,  A61B5/14865

摘要： Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

公开(公告)号：US11714060B2

公开(公告)日：2023-08-01

申请号：US16402124

申请日：2019-05-02

申请人： DexCom, Inc.

发明人： Naresh C. Bhavaraju ,  Becky L. Clark ,  Vincent P. Crabtree ,  Chris W. Dring ,  Arturo Garcia ,  Jason Halac ,  Jonathan Hughes ,  Jeff Jackson ,  Lauren Hruby Jepson ,  David I-Chun Lee ,  Ted Tang Lee ,  Rui Ma ,  Zebediah L. McDaniel ,  Jason Mitchell ,  Andrew Attila Pal ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Stephen J. Vanslyke ,  Matthew D. Wightlin ,  Anna Leigh Davis ,  Hari Hampapuram ,  Aditya Sagar Mandapaka ,  Alexander Leroy Teeter ,  Liang Wang

IPC分类号： G01N27/32 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1495

CPC分类号： G01N27/3274 ,  A61B5/1495 ,  A61B5/14532 ,  A61B2560/0223

摘要： Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.

公开(公告)号：US20230139158A1

公开(公告)日：2023-05-04

申请号：US18089351

申请日：2022-12-27

申请人： DexCom, Inc.

发明人： Jiong Zou ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Shanger Wang

IPC分类号： G01N27/327 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20220183718A1

公开(公告)日：2022-06-16

申请号：US17583128

申请日：2022-01-24

申请人： DexCom, Inc.

发明人： Neel Shah ,  Jennifer Blackwell ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Shanger Wang

IPC分类号： A61B17/34 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/32

摘要： The present disclosure relates to a needle including a wall structure, a cutting edge and a blunt contour. The needle advantageously can be used to deliver a sensor (such as a glucose or other analyte sensor) through an outer skin layer and into a sensor depth in a less invasive way than prior art needles. The size of the cutting edge is balanced against a portion of the distal wall structure that has blunt contours. Thus, the needle is capable of cutting the more durable outer skin layer (first phase) and then progressively stretching open the cut for further advancement into the subcutaneous layer (second phase). When the needle is sufficiently advanced, it is retracted leaving the sensor in a desired position. Early testing has shown a reduction of “dip and recover” from glucose sensors delivered using the needle.

公开(公告)号：US11259842B2

公开(公告)日：2022-03-01

申请号：US15160516

申请日：2016-05-20

申请人： DexCom, Inc.

发明人： Neel Shah ,  Jennifer Blackwell ,  Jonathan Hughes ,  Ted Tang Lee ,  Peter C. Simpson ,  Shanger Wang

IPC分类号： A61B5/145 ,  A61B17/34 ,  A61B5/1486 ,  A61M5/32

摘要： The present disclosure relates to a needle including a wall structure, a cutting edge and a blunt contour. The needle advantageously can be used to deliver a sensor (such as a glucose or other analyte sensor) through an outer skin layer and into a sensor depth in a less invasive way than prior art needles. The size of the cutting edge is balanced against a portion of the distal wall structure that has blunt contours. Thus, the needle is capable of cutting the more durable outer skin layer (first phase) and then progressively stretching open the cut for further advancement into the subcutaneous layer (second phase). When the needle is sufficiently advanced, it is retracted leaving the sensor in a desired position. Early testing has shown a reduction of “dip and recover” from glucose sensors delivered using the needle.

公开(公告)号：US11160926B1

公开(公告)日：2021-11-02

申请号：US17369535

申请日：2021-07-07

申请人： DexCom, Inc.

发明人： Jason Halac ,  John Charles Barry ,  Becky L. Clark ,  Chris W. Dring ,  John Michael Gray ,  Kris Elliot Higley ,  Jeff Jackson ,  David A. Keller ,  Ted Tang Lee ,  Jason Mitchell ,  Kenneth Pirondini ,  David Rego ,  Ryan Everett Schoonmaker ,  Peter C. Simpson ,  Craig Thomas Gadd ,  Kyle Thomas Stewart ,  John Stanley Hayes

IPC分类号： A61M5/172 ,  A61B5/145 ,  A61M5/142 ,  A61M11/00 ,  A61M15/00 ,  G16H40/63 ,  G16H20/17 ,  A61M35/00 ,  A61M5/20 ,  A61B5/00 ,  A61M5/00 ,  A61M5/178 ,  A61M5/30

摘要： Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

公开(公告)号：US20170188902A1

公开(公告)日：2017-07-06

申请号：US15394650

申请日：2016-12-29

申请人： DexCom, Inc.

发明人： Shanger Wang ,  Ted Tang Lee ,  Jiong Zou

IPC分类号： A61B5/1473 ,  C12Q1/00 ,  A61B5/145 ,  C12N11/08

CPC分类号： G01N27/3273 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/12 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  C08G18/0828 ,  C08G18/12 ,  C08G18/3857 ,  C08G18/4018 ,  C08G18/44 ,  C08G18/4833 ,  C08G18/755 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12N11/08 ,  C12Q1/002 ,  C12Q1/006 ,  G01N27/3275 ,  G01N33/66 ,  C08G18/3234

摘要： Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20240293050A1

公开(公告)日：2024-09-05

申请号：US18646451

申请日：2024-04-25

申请人： DexCom, Inc.

发明人： Peter C. Simpson ,  Minglian Shi ,  Sebastian Bohm ,  Maria Noel Brown Wells ,  John Patrick Majewski ,  Leah Morta Edra ,  Disha B. Sheth ,  John Michael Gray ,  Shanger Wang ,  Ted Tang Lee ,  Michael L. Moore ,  Jason Mitchell ,  Jennifer Blackwell ,  Neel Narayan Shah ,  Todd Andrew Newhouse ,  Jason Halac ,  Ryan Everett Schoonmaker ,  Paul V. Neale ,  Jiong Zou ,  Sean T. Saint

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/1486

CPC分类号： A61B5/14532 ,  A61B5/14503 ,  A61B5/683 ,  A61B5/6833 ,  A61B5/0004 ,  A61B5/0015 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/6849 ,  A61B2560/045

摘要： Sensor systems can be used to measure an analyte concentration. Sensor systems can include a base having a distal side configured to face towards a person's skin. An adhesive can couple the base to the skin. A transcutaneous analyte measurement sensor can be coupled to the base and can be located at least partially in the host. A transmitter can be coupled to the base and can transmit analyte measurement data to a remote device.

公开(公告)号：US11656195B2

公开(公告)日：2023-05-23

申请号：US16402101

申请日：2019-05-02

申请人： DexCom, Inc.

发明人： Naresh C. Bhavaraju ,  Becky L. Clark ,  Vincent P. Crabtree ,  Chris W. Dring ,  Arturo Garcia ,  Jason Halac ,  Jonathan Hughes ,  Jeff Jackson ,  Lauren Hruby Jepson ,  David I-Chun Lee ,  Ted Tang Lee ,  Rui Ma ,  Zebediah L. McDaniel ,  Jason Mitchell ,  Andrew Attila Pal ,  Daiting Rong ,  Disha B. Sheth ,  Peter C. Simpson ,  Stephen J. Vanslyke ,  Matthew D. Wightlin ,  Anna Leigh Davis ,  Hari Hampapuram ,  Aditya Sagar Mandapaka ,  Alexander Leroy Teeter ,  Liang Wang

IPC分类号： G01N27/327 ,  A61B5/145 ,  A61B5/1495

CPC分类号： G01N27/3274 ,  A61B5/1495 ,  A61B5/14532 ,  A61B2560/0223

摘要： Systems and methods are provided that address the need to frequently calibrate analyte sensors, according to implementation. In more detail, systems and methods provide a preconnected analyte sensor system that physically combines an analyte sensor to measurement electronics during the manufacturing phase of the sensor and in some cases in subsequent life phases of the sensor, so as to allow an improved recognition of sensor environment over time to improve subsequent calibration of the sensor.