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    Hyaluronic Acid Binding Peptides Enhance Host Defense Against Pathogenic Bacteria
    6.
    发明申请
    Hyaluronic Acid Binding Peptides Enhance Host Defense Against Pathogenic Bacteria 有权
    透明质酸结合肽增强宿主防治病原菌

    公开(公告)号：US20090030180A1

    公开(公告)日：2009-01-29

    申请号：US11917012

    申请日：2006-06-08

    Applicant: Tadeusz Kolodka ,  Bernard T. Charlton ,  Wendy Johnson

    Inventor： Tadeusz Kolodka ,  Bernard T. Charlton ,  Wendy Johnson

    IPC: C07K7/00

    CPC classification number: C07K14/001 ,  A61K38/00

    Abstract: Several species of bacteria capable of invasive infections, such as S. pyogenes, S. equi and P. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such as Staphylococcus aureus and related Staphylococci have capsules that contain acidic polysaccharides. Bacterial capsule or bacterial surface binding peptides were synthesized and tested in a culture model of invasive bacterial infections, specifically translocation through polarized keratinocyte cultures. The peptides reduced the translo-cation of a variety of bacterial species, with a concomitant increase in bacterial internalization by the keratinocytes. In vivo, subcutaneous inoculation of encapsulated GAS treated with peptides delayed bacterial dissemination. In a mouse surgical wound control model infected with S. aureus, treatment with peptides reduced the numbers of bacteria and inflammation at the wound site.

    Abstract translation: 能够侵入性感染的几种细菌，如化脓性链球菌，马氏足球杆菌和多发性球菌，在其胶囊中含有透明质酸（HA）。 细菌物种如金黄色葡萄球菌和相关葡萄球菌含有含有酸性多糖的胶囊。 在侵入性细菌感染的培养模型中，特异性通过极化角化细胞培养物移位合成细菌胶囊或细菌表面结合肽并进行测试。 这些肽减少了各种细菌物种的转铁蛋白，伴随角质细胞细菌内化的增加。 在体内，皮下接种用肽处理的包封的GAS延迟细菌传播。 在用金黄色葡萄球菌感染的小鼠手术伤口控制模型中，用肽处理减少伤口部位的细菌数量和炎症。

    Tablet dispenser
    7.
    发明授权
    Tablet dispenser 失效
    平板电脑

    公开(公告)号：US5897025A

    公开(公告)日：1999-04-27

    申请号：US836538

    申请日：1997-10-22

    Applicant: Harry Flewitt ,  Wendy Johnson ,  Stephen Barnet Lewis

    Inventor： Harry Flewitt ,  Wendy Johnson ,  Stephen Barnet Lewis

    IPC: A61J7/00 ,  B65D83/04 ,  B65G59/00

    CPC classification number: B65D83/0409

    Abstract: A container for dispensing tablets in which the dispensing opening and/or a dispensing passage upstream of the dispensing opening is constricted such that a tablet is releasably retained with part of the tablet projecting outside of the dispensing opening. The part of the rim of the dispensing opening or an adjacent part of the container is movable relative to the rest of the container so as to facilitate the release of the retained tablet from the container.

    Abstract translation: PCT No.PCT / EP95 / 04514 Sec。 371日期1997年10月22日第 102（e）日期1997年10月22日PCT 1995年11月15日PCT PCT。 第WO96 / 15959号公报 日期1996年5月30日用于分配片剂的容器，其中分配开口和/或分配开口上游的分配通道被收缩，使得片剂可释放地保持，片剂的一部分突出到分配开口外侧。 分配开口的边缘部分或容器的相邻部分相对于容器的其余部分是可移动的，以便于将保留的片剂从容器中释放出来。

    Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
    8.
    发明授权
    Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria 有权
    透明质酸结合肽增强宿主防御病原菌

    公开(公告)号：US08044022B2

    公开(公告)日：2011-10-25

    申请号：US11917012

    申请日：2006-06-08

    Applicant: Tadeusz Kolodka ,  Bernard T. Charlton ,  Wendy Johnson

    Inventor： Tadeusz Kolodka ,  Bernard T. Charlton ,  Wendy Johnson

    IPC: A01N37/18 ,  A61K38/04 ,  A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

    CPC classification number: C07K14/001 ,  A61K38/00

    Abstract: Several species of bacteria capable of invasive infections, such as S. pyogenes, S. equi and P. multocida, contain hyaluronic acid (HA) in their capsules. Bacterial species such as Staphylococcus aureus and related Staphylococci have capsules that contain acidic polysaccharides. Bacterial capsule or bacterial surface binding peptides were synthesized and tested in a culture model of invasive bacterial infections, specifically translocation through polarized keratinocyte cultures. The peptides reduced the translocation of a variety of bacterial species, with a concomitant increase in bacterial internalization by the keratinocytes. In vivo, subcutaneous inoculation of encapsulated GAS treated with peptides delayed bacterial dissemination. In a mouse surgical wound model infected with S. aureus, treatment with peptides reduced the numbers of bacteria and inflammation at the wound site.

    Abstract translation: 能够侵入性感染的几种细菌，如化脓性链球菌，马氏足球杆菌和多发性球菌，在其胶囊中含有透明质酸（HA）。 细菌物种如金黄色葡萄球菌和相关葡萄球菌含有含有酸性多糖的胶囊。 在侵入性细菌感染的培养模型中，特异性通过极化角化细胞培养物移位合成细菌胶囊或细菌表面结合肽并进行测试。 肽减少了各种细菌物种的易位，伴随角质细胞细菌内化的增加。 在体内，皮下接种用肽处理的包封的GAS延迟细菌传播。 在用金黄色葡萄球菌感染的小鼠手术伤口模型中，用肽处理减少了创伤部位的细菌数量和炎症。

    Tocopheryl polyethylene glycol succinate powder and process for preparing same
    9.
    发明申请
    Tocopheryl polyethylene glycol succinate powder and process for preparing same 审中-公开
    生育酚聚乙二醇琥珀酸酯粉末及其制备方法

    公开(公告)号：US20070184117A1

    公开(公告)日：2007-08-09

    申请号：US11493215

    申请日：2006-07-26

    Applicant: Stephen Gregory ,  Bruce Jones ,  Andy Singleton ,  Wendy Johnson

    Inventor： Stephen Gregory ,  Bruce Jones ,  Andy Singleton ,  Wendy Johnson

    IPC: A61K9/14

    CPC classification number: A61K31/355 ,  A23P10/40 ,  A61K9/145 ,  A61K47/34

    Abstract: A powdered tocopheryl polyethylene glycol succinate (TPGS™) having an average particle size of less than about 1000 microns. In one embodiment, the powdered tocopheryl polyethylene glycol succinate is prepared by a process that includes atomizing a fluidic tocopheryl polyethylene glycol succinate into an environment suitable for solidifying the atomized tocopheryl polyethylene glycol succinate. In another embodiment, the powdered tocopheryl polyethylene glycol succinate is prepared by a process of applying a force to a solid tocopheryl polyethylene glycol succinate starting material that is sufficient to produce a powdered product.

    Abstract translation: 平均粒度小于约1000微米的粉末生育酚聚乙二醇琥珀酸酯（TPGS TM）。 在一个实施方案中，粉末生育酚聚乙二醇琥珀酸酯通过包括将流体生育酚聚乙二醇琥珀酸酯雾化成适于固化雾化的生育酚聚乙二醇琥珀酸酯的环境的方法制备。 在另一个实施方案中，粉末生育酚聚乙二醇琥珀酸酯通过向固体生育酚聚乙二醇琥珀酸酯起始原料施加足以产生粉末状产物的方法来制备。

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