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公开(公告)号：US08123146B2
公开(公告)日：2012-02-28
申请号：US11657664
申请日：2007-01-25
Applicant: David Hawley , Ronald J. Molz , James Leach
Inventor： David Hawley , Ronald J. Molz , James Leach
Abstract: Shaping the feed wire for a combustion wire thermal spray process improves the operating capability of the combustion wire gun through higher feed rates and high operating efficiencies. The efficiency of the wire melting is increased over conventional systems through increasing the surface area of the wire cross section and exposing more of the wire material directly to the burner jets.
Abstract translation: 整形用于燃烧线热喷涂工艺的进料丝通过更高的进料速率和高的运行效率来改善燃烧钢丝枪的操作能力。 通过增加导线横截面的表面积并将更多的线材直接暴露于燃烧器喷嘴，线材熔化的效率比常规系统增加。
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公开(公告)号：US20070170274A1
公开(公告)日：2007-07-26
申请号：US11657664
申请日：2007-01-25
Applicant: David Hawley , Ronald J. Molz , James Leach
Inventor： David Hawley , Ronald J. Molz , James Leach
IPC: B05B1/24
Abstract: Shaping the feed wire for a combustion wire thermal spray process improves the operating capability of the combustion wire gun through higher feed rates and high operating efficiencies. The efficiency of the wire melting is increased over conventional systems through increasing the surface area of the wire cross section and exposing more of the wire material directly to the burner jets.
Abstract translation: 整形用于燃烧线热喷涂工艺的进料丝通过更高的进料速率和高的运行效率来改善燃烧钢丝枪的操作能力。 通过增加导线横截面的表面积并将更多的线材直接暴露于燃烧器喷嘴，线材熔化的效率比常规系统增加。
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公开(公告)号：US09683282B2
公开(公告)日：2017-06-20
申请号：US12489088
申请日：2009-06-22
Applicant: Ronald J. Molz , James Leach
Inventor： Ronald J. Molz , James Leach
Abstract: Powder injection apparatus, plasma gun, and method of use. Powder injection apparatus includes a shroud attachable to an outlet nozzle of a thermal spray apparatus and a substantially smooth and continuous inner wall defining a bowl through which a plume of the thermal spray apparatus travels. At least one port in the inner wall is structured and arranged to receive a powder injection nozzle that injects powder into the plume.
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公开(公告)号：US20080081796A1
公开(公告)日：2008-04-03
申请号：US11931613
申请日：2007-10-31
Applicant: Robert Shalwitz , Tapas Das , Paul Johns , James Leach
Inventor： Robert Shalwitz , Tapas Das , Paul Johns , James Leach
IPC: A61K31/7072 , A61K31/7076 , A61P1/04
CPC classification number: A61K9/0095 , A61K9/0056 , A61K9/2059 , A61K9/4866 , A61K31/7072 , A61K31/7076 , A61K31/708
Abstract: Disclosed are compositions and methods for alleviating mucositis, wherein said methods and compositions are directed to the formulation or use of selected nucleoside derivatives, especially ADP-ribose, that conform to the general formula A-B-X and pharmaceutically acceptable salts thereof, wherein “A” is a nucleoside structure selected from adenosine, guanosine, and uridine; “B” is a diphosphate linkage attached to the 5′ carbon of the nucleoside ribose moiety; and “X” is attached to B an is a moiety selected from hydrogen, furanose, or pyranose. Also disclosed are pharmaceuticals and nutritional liquid embodiments thereof, including lozenges, mouthwashes, or other product forms that effectively coat the oral, laryngeal or other mucosal areas. It has been found that these compositions and methods effectively alleviate mucositis in susceptible individuals, especially when administered prior to, during, or after treatments commonly associated with the development of mucositis such as certain chemotherapies, radiation therapies, or combinations thereof.
Abstract translation: 公开了用于缓解粘膜炎的组合物和方法，其中所述方法和组合物涉及配制或使用符合通式ABX及其药学上可接受的盐的选定的核苷衍生物，特别是ADP-核糖，其中“A”是 选自腺苷，鸟苷和尿苷的核苷结构; “B”是连接到核苷核糖部分的5'碳上的二磷酸键; 和“X”连接于B an是选自氢，呋喃糖或吡喃糖的部分。 还公开了其药物和营养液体实施方案，包括有效地涂覆口腔，喉部或其他粘膜区域的锭剂，漱口剂或其它产品形式。 已经发现，这些组合物和方法有效地缓解易感个体中的粘膜炎，特别是在通常与粘膜炎发展相关的治疗之前，期间或之后施用，例如某些化学疗法，放射疗法或其组合时。
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公开(公告)号：US20130056446A1
公开(公告)日：2013-03-07
申请号：US13696927
申请日：2011-05-10
Applicant: James Leach
Inventor： James Leach
Abstract: Thermal spray wire and method of forming thermal spray wire. The thermal spray wire includes an inner layer, a powder material layer surrounding the inner layer, and an outer layer coaxially surrounding and compressing the powder material layer around the inner layer.
Abstract translation: 热喷丝和热喷丝的形成方法。 热喷涂线包括内层，围绕内层的粉末材料层和外层，其围绕内层同轴地围绕和压缩粉末材料层。
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Patent Agency Ranking
公开(公告)号：US5765143A
公开(公告)日：1998-06-09
申请号：US402025
申请日：1995-03-10
Applicant: David E. Sheldon , James Leach , Vladimir Pisarsky
Inventor： David E. Sheldon , James Leach , Vladimir Pisarsky
CPC classification number: G06Q10/087 , G06Q20/203
Abstract: A computer system and computer-implemented method for controlling inventory of vendors at one level of a part distribution chain. The system includes a computer programmed with software for generating order data in response to reference data indicative of sales, inventory, demographics, and/or market characteristics of or pertaining to at least two vendors at the same distribution level. The order data is indicative of one or more of a recommended inventory increase transaction (such as a reorder by a vendor of a sold part); an inventory reduction transaction (such as a return of one or more parts in stock at the vendor); and a recommended stocking level of one or more parts by the vendor. When the computer is operated by personnel of a first vendor, it receives reference data concerning at least one other vendor at the same distribution level (in addition to processing reference data concerning the first vendor. When the computer is a host computer, it receives reference data from two or more vendors at the same distribution level. Preferably, the computer which generates the order data is programmed to generate the order data by processing forecast data which is generated by processing the reference data. To generate the forecast data, the computer preferably implements a point-of-sale based method or an actuarial method to determine a forecast of sales of a part by a vendor in a selected time period.
Abstract translation: 一种用于控制零件分销链一级供应商库存的计算机系统和计算机实现的方法。 该系统包括用于产生订单数据的软件的计算机，用于响应于指示相同分配级别的至少两个供应商的销售，库存，人口统计特征和/或市场特征的参考数据。 订单数据表示推荐的库存增加交易中的一个或多个（例如卖方的卖方的重新排序）; 库存减少交易（例如供应商的库存中的一个或多个零件的回报）; 以及供应商推荐的一个或多个部件的储存水平。 当计算机由第一供应商的人员操作时，它接收与相同分配级别的至少一个其他供应商有关的参考数据（除了处理与第一供应商有关的参考数据之外，当计算机是主计算机时，它接收参考 优选地，生成订单数据的计算机被编程为通过处理通过处理参考数据产生的预测数据来生成订单数据，为了产生预测数据，优选地，计算机 实施基于销售点的方法或精算方法来确定供应商在所选时间段内部分销售的预测。
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公开(公告)号：US20060128874A1
公开(公告)日：2006-06-15
申请号：US10532867
申请日：2003-10-29
Applicant: Fareeduddin Farooq , Andrew Janowicz , James Leach , Philip Janowicz
Inventor： Fareeduddin Farooq , Andrew Janowicz , James Leach , Philip Janowicz
IPC: C08L31/00
CPC classification number: C08F292/00 , C08F220/14 , C08F265/06 , C08J5/18 , C08J2333/00 , C08L33/08 , C08L33/12 , C08F222/1006 , C08F220/18 , C08L2666/04
Abstract: The present invention relates to a thermoformable sheet, for example, an acrylic sheet, comprising particles proximate to the top surface, wherein the textured sheet, when thermoformed, provides a low-gloss, textured surface that is less sensitive to marring, blemishes (including blemishes resulting from the mold), household wear and tear, and visibly reduces the appearance of oil deposits on its surface.
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8.发明申请Use of soluble monovalent oligosaccharides as inhibitors of HIV-1 fusion and replication 审中-公开使用可溶性一价低聚糖作为HIV-1融合和复制的抑制剂公开(公告)号：US20050085441A1
公开(公告)日：2005-04-21
申请号：US10797730
申请日：2004-03-10
Applicant: James Leach , Stacey Borowicz , Pedro Prieto , Balbino Alarcon , Ricardo Rueda , Enrique Vazquez
Inventor： James Leach , Stacey Borowicz , Pedro Prieto , Balbino Alarcon , Ricardo Rueda , Enrique Vazquez
IPC: A61K31/715
CPC classification number: A61K31/715
Abstract: The subject invention relates to monovalent oligosaccharides and their use, for example, in the treatment and prevention of mammalian disease caused by HIV-1 virus infections. In particular, the oligosaccharides globotriose and lactose may be used alone or in combination to competitively inhibit the formation of the viral fusion complex that occurs upon infection.
Abstract translation: 本发明涉及一价低聚糖及其用于治疗和预防HIV-1病毒感染引起的哺乳动物疾病的用途。 特别地，寡糖球三糖和乳糖可以单独使用或组合使用，以竞争性地抑制感染时发生的病毒融合复合物的形成。
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公开(公告)号：US07250472B1
公开(公告)日：2007-07-31
申请号：US10490355
申请日：1999-10-25
Applicant: Fareeduddin Farooq , James Leach , Michael R. Turbeville , Andrew H. Janowicz , Richard D. Redfearn
Inventor： Fareeduddin Farooq , James Leach , Michael R. Turbeville , Andrew H. Janowicz , Richard D. Redfearn
IPC: C08L33/12
CPC classification number: C08L33/10 , C08L2205/02 , C08L2205/22 , C08L2666/04
Abstract: Acrylic compositions which can be processed into thermoformable acrylic sheet material with variegated non-homogeneous granite appearance are disclosed. The acrylic compositions comprise a matrix of polymethyl methacrylate having dispersed within it particles of a thermoplastic such as polymethyl methacrylate and one or more comonomers wherein the thermoplastic is in the shape of thin wafers 0.05 to 9.53 mm thick, 0.18 to 12.8 wide and 0.18 to 7.62 mm long.
Abstract translation: 公开了可加工成具有杂色非均匀花岗岩外观的可热成形丙烯酸片材的丙烯酸组合物。 丙烯酸组合物包含聚甲基丙烯酸甲酯基质，其中分散有热塑性塑料如聚甲基丙烯酸甲酯和一种或多种共聚单体的颗粒，其中热塑性塑料为0.05至9.53mm厚的薄片，0.18至12.8宽和0.18至7.62 毫米长。
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公开(公告)号：US20060105985A1
公开(公告)日：2006-05-18
申请号：US11318677
申请日：2005-12-27
Applicant: Robert Shalwitz , Tapas Das , Paul Johns , James Leach
Inventor： Robert Shalwitz , Tapas Das , Paul Johns , James Leach
IPC: A61K31/7076 , A61K31/7072
CPC classification number: A61K9/0095 , A61K9/0056 , A61K9/2059 , A61K9/4866 , A61K31/7072 , A61K31/7076 , A61K31/708
Abstract: Disclosed are compositions and methods for alleviating mucositis, wherein said methods and compositions are directed to the formulation or use of selected nucleoside derivatives, especially ADP-ribose, that conform to the general formula A-B-X and pharmaceutically acceptable salts thereof, wherein “A” is a nucleoside structure selected from adenosine, guanosine, and uridine; “B” is a diphosphate linkage attached to the 5′ carbon of the nucleoside ribose moiety; and “X” is attached to B an is a moiety selected from hydrogen, furanose, or pyranose. Also disclosed are pharmaceuticals and nutritional liquid embodiments thereof, including lozenges, mouthwashes, or other product forms that effectively coat the oral, laryngeal or other mucosal areas. It has been found that these compositions and methods effectively alleviate mucositis in susceptible individuals, especially when administered prior to, during, or after treatments commonly associated with the development of mucositis such as certain chemotherapies, radiation therapies, or combinations thereof.
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