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公开(公告)号：US20080003329A1
公开(公告)日：2008-01-03
申请号：US11479504
申请日：2006-06-30
Applicant: Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret H. Dohnalek
Inventor： Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret H. Dohnalek
IPC: A23L1/30
CPC classification number: A23L33/40
Abstract: Disclosed are infant formulas comprising fat, protein, carbohydrate, vitamins, and minerals, including on an as-fed basis (A) at least about 5 mg/L of gangliosides, (B) at least about 150 mg/L of phospholipids, and (C) lactoferrin, and (D) at least about 70 mg/L of sialic acid, with at least about 2.5% by weight of the sialic acid as lipid-bound sialic acid. Also disclosed are methods of using the formula to reduce the risk of diarrhea infants, and to produce a gut microflora profile similar to that of breast-fed infants.
Abstract translation: 本发明公开了包含脂肪，蛋白质，碳水化合物，维生素和矿物质的婴儿配方，包括至少约5mg / L的神经节苷脂，（B）至少约150mg / L的磷脂，以及 （C）乳铁蛋白，和（D）至少约70mg / L的唾液酸，至少约2.5重量％的唾液酸作为脂质结合的唾液酸。 还公开了使用该配方降低腹泻婴儿风险的方法，以及产生与母乳喂养婴儿相似的肠道微生物群落谱。
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2.发明申请METHODS FOR IMPROVING BRAIN DEVELOPMENT AND COGNITIVE FUNCTION USING BETA-HYDROXY-BETA METHYLBUTYRATE 有权使用β-羟基 - 甲基丁酸酯改善脑发育和认知功能的方法公开(公告)号：US20140249223A1
公开(公告)日：2014-09-04
申请号：US13984906
申请日：2012-02-13
Applicant: Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Ricardo Rueda Cabrera
Inventor： Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Ricardo Rueda Cabrera
IPC: A61K31/19
CPC classification number: A61K31/19 , A23L33/10 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/322 , A23V2250/06
Abstract: Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.
Abstract translation: 公开了用于增强个体如老年人中的神经功能的方法。 所述方法包括向个体施用包含HMB的营养组合物。 营养组合物对于具有或可能具有认知衰退，认知障碍和神经功能障碍（通常由与神经变性疾病相关的认知疾病引起）的风险的个体提供益处。
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3.发明申请METHODS FOR IMPROVING BONE HEALTH IN INFANTS USING LONG CHAIN POLYUNSATURATED FATTY ACIDS 审中-公开使用长链多糖脂肪酸改善婴幼儿骨骼健康的方法公开(公告)号：US20120245121A1
公开(公告)日：2012-09-27
申请号：US13424847
申请日：2012-03-20
Applicant: Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Ricardo Rueda Cabrera
IPC: A61K31/202 , A61K31/715 , A61P19/00
CPC classification number: A61K31/201 , A23L33/12 , A23L33/155 , A23L33/16 , A23L33/22 , A23L33/40 , A23V2002/00
Abstract: Disclosed are methods for improving bone health, strength and formation in an infant who may be susceptible to developing bone health issues from conception through adolescence. The methods include administration of a nutritional formulation including at least one LCPUFA to a woman during pregnancy and optionally during lactation and breastfeeding of an infant.
Abstract translation: 公开了一种改善骨骼健康，强度和形成能力的方法，婴儿可能容易从受孕到青春期发展骨骼健康问题。 所述方法包括在怀孕期间和任选地在哺乳期和哺乳期期间向女性施用包含至少一种LCPUFA的营养制剂。
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公开(公告)号：US20080064635A1
公开(公告)日：2008-03-13
申请号：US11771417
申请日：2007-06-29
Applicant: Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret Dohnalek
Inventor： Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret Dohnalek
CPC classification number: A61K33/00 , A23L33/12 , A23L33/19 , A23L33/40 , A61K31/202 , A61K31/28 , A61K31/685 , A61K31/7008 , A61K31/7032 , A61K38/00 , A61K45/06
Abstract: Disclosed are infant formulas comprising at least about 6.5 g/L, on an as-fed basis, of an enriched whey protein concentrate, at least about 0.13% docosahexaenoic acid by weight of total fatty acids, and at least about 0.25% arachidonic acid by weight of total fatty acids. The formulas also typically include at least about 5 mg/L of gangliosides, at least about 150 mg/L of phospholipids, and at least about 70 mg/L of total sialic acid with at least about 2.5% as lipid-bound sialic acid, all of which are provided in whole or in part from the enriched whey protein concentrate. Also disclosed are methods of accelerating brain development, neural migration, and cognitive development in an infant by administering the infant formulas during the first 2-4 months of life, preferably as a sole source of nutrition.
Abstract translation: 公开了包含至少约6.5g / L的按照饲料计算的富集的乳清蛋白浓缩物，按总脂肪酸的重量计至少约0.13％的二十二碳六烯酸和至少约0.25％的花生四烯酸的婴儿配方， 总脂肪酸的重量。 配方还通常包括至少约5mg / L的神经节苷脂，至少约150mg / L的磷脂，和至少约70mg / L的总唾液酸，至少约2.5％的脂质结合的唾液酸， 所有这些全部或部分来自富集的乳清蛋白浓缩物。 还公开了通过在生命的前2-4个月内通过施用婴儿配方来优化作为唯一的营养来源来加速婴儿的脑发育，神经迁移和认知发育的方法。
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公开(公告)号：US20080057178A1
公开(公告)日：2008-03-06
申请号：US11771435
申请日：2007-06-29
Applicant: Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret Dohnalek
Inventor： Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret Dohnalek
CPC classification number: A23L33/40
Abstract: Disclosed are infant formulas comprising, on an as-fed basis (A) at least about 5 mg/L of gangliosides, (B) at least about 150 mg/L of phospholipids, (C) lactoferrin, and (D) at least about 70 mg/L of sialic acid, with at least about 2.5% by weight of the sialic acid as lipid-bound sialic acid. From about 50% to 100% by weight of each of the gangliosides, phospholipids, lactoferrin, and sialic acid is provided by an enriched whey protein concentrate, with the concentrate representing at least about 6.5 g/L of the formula on an as-fed basis. Also disclosed are methods of using the formula to reduce the risk of diarrhea infants, and to produce a gut microflora profile similar to that of breast-fed infants.
Abstract translation: 公开了婴儿配方，其包含基于（A）至少约5mg / L的神经节苷脂，（B）至少约150mg / L的磷脂，（C）乳铁蛋白和（D）至少约 70mg / L的唾液酸，至少约2.5重量％的唾液酸作为脂质结合的唾液酸。 通过富集的乳清蛋白浓缩物提供每种神经节苷脂，磷脂，乳铁蛋白和唾液酸的约50重量％至100重量％，浓缩物表示至少约6.5g / L的配方， 基础。 还公开了使用该配方降低腹泻婴儿风险的方法，以及产生与母乳喂养婴儿相似的肠道微生物群落谱。
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Patent Agency Ranking
公开(公告)号：US20080003330A1
公开(公告)日：2008-01-03
申请号：US11479621
申请日：2006-06-30
Applicant: Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret H. Dohnalek
Inventor： Ricardo Rueda , Alejandro Barranco , Maria Ramirez , Enrique Vazquez , Eduardo Valverde , Pedro Prieto , Margaret H. Dohnalek
IPC: A23L1/30
CPC classification number: A61K33/00 , A23L33/12 , A23L33/19 , A23L33/40 , A61K31/202 , A61K31/28 , A61K31/685 , A61K31/7008 , A61K31/7032 , A61K38/00 , A61K45/06
Abstract: Disclosed are infant formulas comprising fat, protein, carbohydrate, vitamins, and minerals, including on an as-fed basis, at least about 5 mg/L of gangliosides, at least about 150 mg/L of phospholipids, at least about 70 mg/L of total sialic acid with at least about 2.5% as lipid-bound sialic acid, at least about 0.13% docosahexaenoic acid by weight of total fatty acids, and at least about 0.25% arachidonic acid by weight of total fatty acids. Also disclosed are methods of accelerating brain development, neural migration, and cognitive development in an infant by administering the infant formulas during the first 2-4 months of life, preferably as a sole source of nutrition.
Abstract translation: 公开了包含脂肪，蛋白质，碳水化合物，维生素和矿物质的婴儿配方，包括以按原料计，至少约5mg / L的神经节苷脂，至少约150mg / L的磷脂，至少约70mg / L的总唾液酸，其具有至少约2.5％的脂质结合的唾液酸，按总脂肪酸的重量计至少约0.13％的二十二碳六烯酸，以及总脂肪酸的至少约0.25％的花生四烯酸。 还公开了通过在生命的前2-4个月内通过施用婴儿配方来优化作为唯一的营养来源来加速婴儿的脑发育，神经迁移和认知发育的方法。
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7.发明申请Use of soluble monovalent oligosaccharides as inhibitors of HIV-1 fusion and replication 审中-公开使用可溶性一价低聚糖作为HIV-1融合和复制的抑制剂公开(公告)号：US20050085441A1
公开(公告)日：2005-04-21
申请号：US10797730
申请日：2004-03-10
Applicant: James Leach , Stacey Borowicz , Pedro Prieto , Balbino Alarcon , Ricardo Rueda , Enrique Vazquez
Inventor： James Leach , Stacey Borowicz , Pedro Prieto , Balbino Alarcon , Ricardo Rueda , Enrique Vazquez
IPC: A61K31/715
CPC classification number: A61K31/715
Abstract: The subject invention relates to monovalent oligosaccharides and their use, for example, in the treatment and prevention of mammalian disease caused by HIV-1 virus infections. In particular, the oligosaccharides globotriose and lactose may be used alone or in combination to competitively inhibit the formation of the viral fusion complex that occurs upon infection.
Abstract translation: 本发明涉及一价低聚糖及其用于治疗和预防HIV-1病毒感染引起的哺乳动物疾病的用途。 特别地，寡糖球三糖和乳糖可以单独使用或组合使用，以竞争性地抑制感染时发生的病毒融合复合物的形成。
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公开(公告)号：US20120270766A1
公开(公告)日：2012-10-25
申请号：US13513456
申请日：2011-06-21
Applicant: Ricardo Rueda Cabrera , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Maria Jesus Martin
Inventor： Ricardo Rueda Cabrera , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Maria Jesus Martin
CPC classification number: A23L33/185 , A23L33/40 , A23V2002/00 , A23V2250/5488 , A23V2200/322
Abstract: Disclosed are methods for improving memory and/or cognition in an infant by administering soy protein to the infant's mother during pregnancy, and further administering soy protein to the infant after delivery. The soy protein may be administered to the infant's mother during lactation if the infant is breastfed and/or may be directly administered, for example, by administering the infant an infant and/or nutritional formula comprising soy protein. Also disclosed are compositions comprising soy protein that may be used in the methods.
Abstract translation: 公开了通过在怀孕期间向婴儿的母亲施用大豆蛋白，并且在分娩后向婴儿进一步投入大豆蛋白来改善婴儿的记忆和/或认知的方法。 如果婴儿母乳喂养，和/或可以直接给予，例如通过给予婴儿婴儿和/或包含大豆蛋白的营养配方，大豆蛋白质可以在哺乳期间对婴儿的母亲施用。 还公开了可用于该方法的包含大豆蛋白的组合物。
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9.发明授权Methods for improving brain development and cognitive function using beta-hydroxy-beta methylbutyrate 有权使用β-羟基-β甲基丁酸改善脑发育和认知功能的方法公开(公告)号：US09326956B2
公开(公告)日：2016-05-03
申请号：US13984906
申请日：2012-02-13
Applicant: Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Ricardo Rueda Cabrera
Inventor： Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Alejandro Barranco Perez , Maria Ramirez Gonzalez , Ricardo Rueda Cabrera
CPC classification number: A61K31/19 , A23L33/10 , A23L33/175 , A23L33/40 , A23V2002/00 , A23V2200/322 , A23V2250/06
Abstract: Disclosed are methods for enhancing neural function in an individual, such as an older adult. The methods include administering nutritional compositions comprising HMB to the individual. The nutritional compositions provide benefits for individuals that have or may be at risk of having cognitive decline, cognitive impairment, and neural dysfunction, typically resulting from cognitive diseases associated with neurodegenerative diseases.
Abstract translation: 公开了用于增强个体如老年人中的神经功能的方法。 所述方法包括向个体施用包含HMB的营养组合物。 营养组合物对于具有或可能具有认知衰退，认知障碍和神经功能障碍（通常由与神经变性疾病相关的认知疾病引起）的风险的个体提供益处。
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公开(公告)号：US20120245123A1
公开(公告)日：2012-09-27
申请号：US13424891
申请日：2012-03-20
Applicant: Jose Maria Lopez Pedrosa , Manuel Manzano Martin , Ricardo Rueda Cabrera
IPC: A61K31/702 , A61P19/00 , A61K31/718
CPC classification number: A61K31/733 , A23L33/115 , A23L33/12 , A23L33/155 , A23L33/16 , A23L33/21 , A23L33/22 , A23L33/40 , A23V2002/00 , A23V2200/306 , A23V2250/156 , A23V2250/1882 , A23V2250/28 , A23V2250/1868 , A23V2250/304 , A23V2250/5046 , A23V2250/5424 , A23V2250/70 , A23V2250/71
Abstract: Disclosed are methods for improving bone health, strength and formation in an infant who may be susceptible to developing bone health issues from conception through adolescence. The methods include administration of a nutritional formulation including a prebiotic to a woman during pregnancy and optionally during lactation and breastfeeding of an infant.
Abstract translation: 公开了一种改善骨骼健康，强度和形成能力的方法，婴儿可能容易从受孕到青春期发展骨骼健康问题。 所述方法包括在怀孕期间和任选地在哺乳期和哺乳期期间给予包括益生元在内的营养制剂。
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