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公开(公告)号:US5976795A
公开(公告)日:1999-11-02
申请号:US771602
申请日:1996-12-20
申请人: Daniel F. Voytas , Sige Zou
发明人: Daniel F. Voytas , Sige Zou
CPC分类号: C12N15/905 , C12N15/81 , A61K48/00
摘要: The present disclosure provides retrotransposons and retrotransposon derivatives and methods for their uses. Specifically, the present invention provides Ty5-6p and derivatives. Ty5-6p and its derivatives integrate preferentially in the genome of eukaryotes in silent chromatin and in regions like silent chromatin. Ty5-6p insertions can be used to regulate the life span of cells, to genetically mark cells, to deliver gene therapy and to identify genes involved in development and in senescence.
摘要翻译: 本公开提供了其用途的反转录转座子和反转录转座子衍生物和方法。 具体地,本发明提供Ty5-6p及其衍生物。 Ty5-6p及其衍生物优先整合到沉默染色质中的真核生物基因组中,在沉默染色质区域。 Ty5-6p插入可用于调节细胞的寿命,遗传标记细胞,提供基因治疗和鉴定参与发育和衰老的基因。
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公开(公告)号:US20120214228A1
公开(公告)日:2012-08-23
申请号:US13426991
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
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公开(公告)号:US08440431B2
公开(公告)日:2013-05-14
申请号:US13427040
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
摘要翻译: 提供了与基因靶向相关的材料和方法(例如,用转录激活子样效应核酸酶进行基因靶向;“TALENS”)。
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公开(公告)号:US06331662B1
公开(公告)日:2001-12-18
申请号:US09322478
申请日:1999-05-28
申请人: David A. Wright , Daniel F. Voytas
发明人: David A. Wright , Daniel F. Voytas
IPC分类号: C12N1533
CPC分类号: C12N15/8203 , C07K14/415 , C12N15/86 , C12N2740/10022 , C12N2740/10043 , C12N2800/90
摘要: The present invention provides plant retroelements useful as molecular tools. In one embodiment, the present invention provides nucleic acids encoding gag, pol and/or env genes of plant retroelements. The elements can be used, among other uses, as building blocks of other constructs, tools to find other nucleic acid sequences and tools to transfer nucleic acid into cells.
摘要翻译: 本发明提供可用作分子工具的植物逆转元件。 在一个实施方案中,本发明提供编码植物逆转录酶的gag,pol和/或env基因的核酸。 除了其它用途之外,这些元件可以用作其他构建体的构建块,以找到将核酸转移到细胞中的其它核酸序列和工具的工具。
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公开(公告)号:US08450471B2
公开(公告)日:2013-05-28
申请号:US13426991
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
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公开(公告)号:US20120178131A1
公开(公告)日:2012-07-12
申请号:US13427040
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
摘要翻译: 提供了与基因靶向相关的材料和方法(例如,用转录激活子样效应核酸酶进行基因靶向;“TALENS”)。
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公开(公告)号:US06720479B1
公开(公告)日:2004-04-13
申请号:US09586106
申请日:2000-06-02
申请人: David A. Wright , Daniel F. Voytas
发明人: David A. Wright , Daniel F. Voytas
IPC分类号: C12N504
CPC分类号: C07K14/415 , C12N15/8202 , C12N15/8203 , C12N15/86 , C12N2740/10022 , C12N2740/10043
摘要: The present invention provides plant retroelements useful as molecular tools. In one embodiment, the present invention provides nucleic acids encoding gag, pol and/or env genes of plant retroelements. The elements can be used, among other uses, as building blocks of other constructs, tools to find other nucleic acid sequences and tools to transfer nucleic acid into cells.
摘要翻译: 本发明提供可用作分子工具的植物逆转元件。 在一个实施方案中,本发明提供编码植物逆转录酶的gag,pol和/或env基因的核酸。 除了其它用途之外,这些元件可以用作其他构建体的构建块,以找到将核酸转移到细胞中的其它核酸序列和工具的工具。
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公开(公告)号:US08586363B2
公开(公告)日:2013-11-19
申请号:US12965590
申请日:2010-12-10
申请人: Daniel F. Voytas , Adam Bogdanove , Feng Zhang , Michelle Christian , Tomas Cermak , Clarice Lauer Schmidt , Erin Doyle , Li Wang
发明人: Daniel F. Voytas , Adam Bogdanove , Feng Zhang , Michelle Christian , Tomas Cermak , Clarice Lauer Schmidt , Erin Doyle , Li Wang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
摘要翻译: 提供与基因靶向相关的材料和方法(例如,用转录激活子样效应核酸酶进行基因靶向;“TALENS”)。
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公开(公告)号:US08440432B2
公开(公告)日:2013-05-14
申请号:US13427137
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
摘要翻译: 提供了与基因靶向相关的材料和方法(例如,用转录激活子样效应核酸酶进行基因靶向;“TALENS”)。
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公开(公告)号:US20120178169A1
公开(公告)日:2012-07-12
申请号:US13427137
申请日:2012-03-22
申请人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
发明人: Daniel F. Voytas , Adam J. Bogdanove , Feng Zhang
CPC分类号: C12N9/22 , C12N15/01 , C12N15/102 , C12N15/1082 , C12N15/62 , C12N15/63 , C12Y301/21004
摘要: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.
摘要翻译: 提供与基因靶向相关的材料和方法(例如,用转录激活子样效应核酸酶进行基因靶向;“TALENS”)。
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