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公开(公告)号：US20190338214A1
公开(公告)日：2019-11-07
申请号：US16515074
申请日：2019-07-18
申请人： DSM IP Assets B.V.
发明人： Stephen Robert CHERINKO , Robert Cody KERTIS , Kirk E. APT , Paul Warren BEHRENS , Jon Milton HANSEN , Joseph W. PFEIFER, III , Tracy Lynn STAHL , Ross E. Zirkle , Nasrin TABAYEHNEJAD , Krishna RAMAN , Neil Francis LEININGER
摘要： The present invention relates to processes for obtaining a lipid from a cell by lysing the cell, contacting the cell with a base and/or salt, and separating the lipid. The present invention is also directed to a lipid prepared by the processes of the present invention. The present invention is also directed to microbial lipids having a particular anisidine value, peroxide value, and/or phosphorus content.
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公开(公告)号：US20190177754A1
公开(公告)日：2019-06-13
申请号：US16273273
申请日：2019-02-12
申请人： DSM IP Assets B.V.
发明人： James Casey LIPPMEIER , Joseph W. PFEIFER, III , Jon Milton HANSEN , Kirk E. APT , William Robert BARCLAY , Paul Warren BEHRENS , David Christian MARTIN
摘要： The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
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3.发明申请公开(公告)号：US20150237888A1
公开(公告)日：2015-08-27
申请号：US14709899
申请日：2015-05-12
申请人： DSM IP ASSETS B.V.
发明人： Kirk E. APT , Paul Warren BEHRENS , Jon Milton HANSEN , Joseph W. PFEIFER, III , Tracey Lynn STAHL , Ross ZIRKLE
CPC分类号： A23K20/158 , A23C9/1528 , A23D9/00 , A23D9/007 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , A23L2/52 , A23L33/115 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K31/201 , A61K31/202 , A61K35/68 , A61K2800/10 , A61Q19/00 , C11B1/10 , C11B3/04 , C12P7/6427 , C12P7/6472 , C12R1/89 , C12R1/90 , Y02A40/818
摘要： The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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公开(公告)号：US20190211369A1
公开(公告)日：2019-07-11
申请号：US16249253
申请日：2019-01-16
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , James Casey LIPPMEIER , David SIMPSON , Jun WANG , James P. WYNN , Ross ZIRKLE
摘要： The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
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5.发明申请THRAUSTOCHYTRIDS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开肉豆蔻酸，脂肪酸组合物及其制备方法及用途公开(公告)号：US20160309748A1
公开(公告)日：2016-10-27
申请号：US15209568
申请日：2016-07-13
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Joseph W. PFEIFER, III , Jon Milton Hansen , Paul Warren BEHRENS , Ross ZIRKLE , Tracey Lynn STAHL
IPC分类号： A23K20/158 , A23L33/12 , A61Q19/00 , A61K36/02 , A61K31/202 , A61K8/99 , A23K50/80 , A23L33/135
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
摘要翻译： 本发明涉及分离的破釜状菌属微生物以及其菌株和突变体。 本发明进一步涉及生物量，微生物油，组合物，培养物，生产微生物油的方法，以及使用分离的破釜蛇疮，生物质和微生物油的方法。
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6.发明申请POLYPEPTIDE FOR IMPROVING PROTEIN PRODUCTION IN MICROORGANISMS OF THE PHYLUM LABYRINTHULOMYCOTA 有权用于改善蛋白质生产在蛋白质微生物中的多肽公开(公告)号：US20150132803A1
公开(公告)日：2015-05-14
申请号：US14548054
申请日：2014-11-19
申请人： DSM IP ASSETS B.V.
发明人： Kirk E. APT , James Casey LIPPMEIER , David SIMPSON , Jun WANG , James P. WYNN , Ross ZIRKLE
IPC分类号： C07K14/705 , C12N15/79
CPC分类号： C12P21/00 , C07K14/37 , C07K14/705 , C12N9/2431 , C12N15/79 , C12N15/80 , C12P21/005 , C12R1/90 , C12Y302/01026
摘要： The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
摘要翻译： 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产和任选地从重组宿主细胞和微生物分泌多肽的新型启动子，终止子和信号序列也包括在本发明中。
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公开(公告)号：US20240081376A1
公开(公告)日：2024-03-14
申请号：US18352386
申请日：2023-07-14
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Joseph W. PFEIFER, III , Jon Milton HANSEN , Paul Warren BEHRENS , Ross ZIRKLE , Tracey Lynn STAHL
IPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A61K8/9728 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61Q19/00 , C12N1/12 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A61K8/9728 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61Q19/00 , C12N1/125 , C12P7/6427 , C12P7/6432 , C12P7/6434 , C12P7/6472 , A61K2035/11
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
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8.发明申请公开(公告)号：US20180295860A1
公开(公告)日：2018-10-18
申请号：US15889842
申请日：2018-02-06
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC分类号： A23K20/158 , A23D9/007 , A23D9/00 , A23L2/52 , A61Q19/00 , A61K31/201 , A61K8/36 , A23L33/115 , A23L33/00 , A23K50/80 , A23K50/40 , A23K50/00 , A23K10/12 , A61K35/68 , C12R1/90 , C12R1/89 , C12P7/64 , C11B3/04 , C11B1/10 , A61K31/202 , A23C9/152
摘要： The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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公开(公告)号：US20180064138A1
公开(公告)日：2018-03-08
申请号：US15790584
申请日：2017-10-23
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Joseph W. PFEIFER, III , Jon Milton Hansen , Paul Warren BEHRENS , Ross ZIRKLE , Tracey Lynn STAHL
IPC分类号： C12R1/89 , C12P7/64 , A61Q19/00 , A61K36/02 , A61K31/202 , A61K31/20 , A61K8/99 , A23D9/00 , A61K35/00
CPC分类号： A23K20/158 , A23D9/00 , A23K50/00 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K31/20 , A61K31/202 , A61K36/02 , A61K2035/11 , A61K2800/74 , A61Q19/00 , C12P7/6427 , C12P7/6472 , C12R1/89
摘要： The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
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公开(公告)号：US20170216239A1
公开(公告)日：2017-08-03
申请号：US15481980
申请日：2017-04-07
申请人： DSM IP Assets B.V.
发明人： Kirk E. APT , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer , Tracey Lyy Stahl , Ross Zirkle
IPC分类号： A61K31/202 , A61Q19/00 , A23K50/80 , A23L33/00 , A23L2/52 , A23K20/158 , A61K8/36 , A23L33/12
CPC分类号： A61K31/202 , A23K20/158 , A23K50/80 , A23L2/52 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K2800/10 , A61Q19/00 , C12P7/6427 , A61K2300/00
摘要： The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
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