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公开(公告)号：US10376514B2
公开(公告)日：2019-08-13
申请号：US16164726
申请日：2018-10-18
Applicant: Dart Neuroscience (Cayman) Ltd.
Inventor： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael I. Weinhouse
IPC: C07D495/14 , C07D495/22 , C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22 , C07D491/22 , A61K31/519 , C07D498/08 , C07D491/147 , C07D491/107 , C07D519/00 , C07D495/12 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/5386 , A61P25/00 , A61P9/00
Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.
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公开(公告)号：US20160075719A1
公开(公告)日：2016-03-17
申请号：US14853856
申请日：2015-09-14
Applicant: Dart Neuroscience (Cayman) Ltd.
Inventor： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael Weinhouse
IPC: C07D495/14 , C07D491/147 , C07D495/22 , C07D519/00
CPC classification number: A61K31/553 , A61K31/519 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , C07D471/14 , C07D487/14 , C07D491/107 , C07D491/147 , C07D491/22 , C07D495/12 , C07D495/14 , C07D495/22 , C07D498/08 , C07D519/00
Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.
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公开(公告)号：US20160009691A1
公开(公告)日：2016-01-14
申请号：US14770759
申请日：2014-03-06
Applicant: DART NEUROSCIENCE (CAYMAN) LTD.
Inventor： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark Edward Wilson , James Zapf
IPC: C07D403/06 , C07D401/06 , C07D239/34 , C07D213/64 , C07D405/12 , C07D417/06 , A61K51/04 , C07D401/14
CPC classification number: C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
Abstract: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
Abstract translation: 本发明提供式（I）的化学实体和包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 和治疗方法，包括抑制PDE4，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，提高非人类动物的效率 训练方案和治疗外周疾病，包括炎症和肾脏疾病。
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公开(公告)号：US20180346448A1
公开(公告)日：2018-12-06
申请号：US16001883
申请日：2018-06-06
Applicant: DART NEUROSCIENCE (CAYMAN) LTD.
Inventor： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark E. Wilson , James Zapf
IPC: C07D403/06 , C07D409/14 , C07D409/06 , C07D413/06 , C07D405/14 , C07D401/06 , C07D405/12 , C07D401/14 , C07D241/18 , A61K51/04 , C07D213/81 , C07D213/74 , C07D213/73 , C07D213/64 , C07D239/34 , C07D417/06
CPC classification number: C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
Abstract: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders, including inflammatory and renal disorders.
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![Substituted [1,2,4]triazolo[1,5-A]pyrimidin-7-yl compounds as PDE2 inhibitors](/abs-image/US/2018/04/03/US09932345B2/abs.jpg.150x150.jpg)
公开(公告)号：US09932345B2
公开(公告)日：2018-04-03
申请号：US15306069
申请日：2015-04-22
Applicant: DART NEUROSCIENCE (CAYMAN) LTD.
Inventor： James Breitenbucher , Graeme Freestone , Laurent Gomez , Robert Lemus , Kiev Ly , Margaret McCarrick , William Vernier , Troy Vickers
IPC: C07D487/04 , C07D519/00 , A61K31/519 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
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Patent Agency Ranking
![SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS](/abs-image/US/2017/03/02/US20170057967A1/abs.jpg.150x150.jpg)
6.发明申请SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS 有权取代[1,2,4]三唑并[1,5-A]吡啶二酮-7-YL化合物作为PDE2抑制剂公开(公告)号：US20170057967A1
公开(公告)日：2017-03-02
申请号：US15306069
申请日：2015-04-22
Applicant: DART NEUROSCIENCE (CAYMAN) LTD.
Inventor： James Breitenbucher , Graeme Freestone , Laurent Gomez , Robert Lemus , Kiev Ly , Margaret McCarrick , William Vernier , Troy Vickers
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, X, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.
Abstract translation: 本发明提供式（I）的化学实体：其中R1，R2，X，Y和Z具有本文所述的任何值，以及包含这些化学实体的组合物; 制作方法; 以及它们在本文公开的广泛方法中的用途，包括代谢和反应动力学研究; 检测和成像技术; 放射治疗; 调节和治疗由PDE2活性介导的疾病; 治疗神经系统疾病，中枢神经系统疾病，痴呆，神经变性疾病和创伤依赖性功能丧失; 治疗中风，包括中风康复期间的认知和运动缺陷; 促进神经保护和神经恢复; 提高认知和运动训练的效率，包括动物技能训练方案; 和治疗外周疾病，包括血液学，心血管，胃肠病学和皮肤病学疾病。
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公开(公告)号：US20200024259A1
公开(公告)日：2020-01-23
申请号：US16424366
申请日：2019-05-28
Applicant: DART NEUROSCIENCE (CAYMAN) LTD.
Inventor： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Michael Weinhouse , Mark E. Wilson , James Zapf
IPC: C07D403/06 , C07D401/06 , C07D405/14 , C07D413/06 , C07D417/06 , C07D409/14 , C07D213/73 , C07D213/74 , C07D213/81 , C07D213/64 , C07D241/18 , C07D401/14 , C07D405/12 , C07D409/06 , A61K51/04 , C07D239/34
Abstract: The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
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公开(公告)号：US09956224B2
公开(公告)日：2018-05-01
申请号：US15394058
申请日：2016-12-29
Applicant: Dart Neuroscience (Cayman) Ltd.
Inventor： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael Weinhouse
IPC: A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5386 , A61K31/551
Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.
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公开(公告)号：US09573937B2
公开(公告)日：2017-02-21
申请号：US14720321
申请日：2015-05-22
Applicant: Dart Neuroscience (Cayman) Ltd.
Inventor： Venkataiah Bollu , James Breitenbucher , Alan Kaplan , Robert Lemus , Andrew Lindstrom , Troy Vickers , Mark Wilson , James Zapf
IPC: C07D241/18 , C07D403/06 , C07D401/06 , C07D401/14 , C07D213/64 , C07D405/12 , C07D417/06 , C07D405/14 , C07D413/06 , C07D409/14 , C07D409/06 , C07D213/73 , C07D213/74 , C07D213/81 , A61K51/04 , C07D239/34
CPC classification number: C07D403/06 , A61K51/0459 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/81 , C07D239/34 , C07D241/18 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06
Abstract: The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
Abstract translation: 本发明提供式（I）的化学实体，其中R 1，R 2，R 3，R 4，Y和Z具有本文所述的任何值，以及包含这些化学实体的组合物; 制作方法; 并在广泛的方法中使用，包括代谢和反应动力学研究，检测和成像技术以及放射性治疗; 和治疗方法，包括抑制PDE4，增强神经元可塑性，治疗神经障碍，提供神经保护，治疗与CNS病症相关的认知障碍，提高认知和运动训练的效率，提供神经复发和神经康复，提高非人类动物的效率 训练方案和治疗外周疾病，包括炎症和肾脏疾病。
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10.发明授权Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones 有权治疗噻吩 - ，呋喃和吡啶稠合的偶氮嘧啶-5-（6h） - 酮公开(公告)号：US09533996B2
公开(公告)日：2017-01-03
申请号：US14853856
申请日：2015-09-14
Applicant: Dart Neuroscience (Cayman) Ltd.
Inventor： Bryan Branstetter , James Breitenbucher , Brian Dyck , Laurent Gomez , Andrew Richard Hudson , Tami Jo Marrone , Marco Peters , Troy Vickers , Michael Weinhouse
IPC: C07D495/14 , C07D495/22 , C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22 , C07D491/22 , C07D498/08 , C07D491/147 , C07D491/107 , C07D519/00 , C07D495/12
CPC classification number: A61K31/553 , A61K31/519 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/551 , C07D471/14 , C07D487/14 , C07D491/107 , C07D491/147 , C07D491/22 , C07D495/12 , C07D495/14 , C07D495/22 , C07D498/08 , C07D519/00
Abstract: Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.
Abstract translation: 本文描述了式I和式II的化合物，其合成方法，包含该化合物的组合物，以及该化合物和组合物在治疗众多疾病和病症（包括与CNS疾病和病症相关的认知缺陷）中的用途。
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