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公开(公告)号：US11384375B2
公开(公告)日：2022-07-12
申请号：US15570195
申请日：2016-05-02
申请人： CureVac AG
IPC分类号： C12N9/12 , C12P19/34 , C12N11/06 , C12N11/14 , C12N11/02 , C12N15/10 , C12N15/113 , C12Q1/6806
摘要： The present invention relates to an immobilized poly(N)polymerase (PNP), methods of producing said PNP and uses thereof. Further disclosed is an enzyme reactor and kit comprising the PNP for producing polynucleotidylated ribonucleic acid poly(N)RNA)molecules which are useful in gene therapy, immunotherapy, protein replacement therapy and/or vaccination.
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公开(公告)号：US11179337B2
公开(公告)日：2021-11-23
申请号：US16679536
申请日：2019-11-11
申请人： CureVac AG
发明人： Fabian Johannes Eber , Benyamin Yazdan Panah , Stefanie Sewing , Thomas Ketterer , Thorsten Mutzke , Tilmann Roos , Michael Sonntag , Michael Wiggenhorn , Katharina Kolland
IPC分类号： A61K48/00 , A61K9/16 , A61P31/00 , A61P31/12 , A61P37/06 , A61P37/08 , A61P31/04 , A61P33/02 , A61P35/00 , A61K39/145 , A61K39/00
摘要： The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.
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公开(公告)号：US10729654B2
公开(公告)日：2020-08-04
申请号：US15575301
申请日：2016-05-20
申请人： CureVac AG
发明人： Fabian Johannes Eber , Benyamin Yazdan Panah , Stefanie Sewing , Thomas Ketterer , Thorsten Mutzke , Tilmann Roos , Michael Sonntag , Michael Wiggenhorn , Katharina Kolland
IPC分类号： C07H21/04 , A61K9/16 , A61K48/00 , A61K9/19 , A61K31/7105
摘要： The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.
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公开(公告)号：US10517827B2
公开(公告)日：2019-12-31
申请号：US15575284
申请日：2016-05-20
申请人： CureVac AG
发明人： Fabian Johannes Eber , Benyamin Yazdan Panah , Stefanie Sewig , Thomas Ketterer , Thorsten Mutzke , Tilmann Roos , Michael Sonntag , Michael Wiggenhorn , Katharina Kolland
IPC分类号： C07H21/04 , A61K9/16 , A61K48/00 , A61P31/00 , A61P31/12 , A61P37/06 , A61P37/08 , A61P31/04 , A61P33/02 , A61P35/00 , A61K39/145 , A61K39/00
摘要： The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.
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公开(公告)号：US11248223B2
公开(公告)日：2022-02-15
申请号：US16012751
申请日：2016-12-23
申请人： CureVac AG
IPC分类号： C12N15/10 , C12P19/34 , C12Q1/6844
摘要： The present invention relates to a buffer system comprising a dicarboxylic acid or tricarboxylic acid or a salt thereof for synthesizing RNA molecules as well as a method of RNA in vitro transcription using this buffer system. The present invention also provides the use of this buffer system in RNA in vitro transcription and in the reduction or prevention of precipitates during RNA in vitro transcription.
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公开(公告)号：US11534405B2
公开(公告)日：2022-12-27
申请号：US16904993
申请日：2020-06-18
申请人： CureVac AG
发明人： Fabian Johannes Eber , Benyamin Yazdan Panah , Stefanie Sewing , Thomas Ketterer , Thorsten Mutzke , Tilmann Roos , Michael Sonntag , Michael Wiggenhorn , Katharina Kolland
IPC分类号： C07H21/04 , A61K9/16 , A61K48/00 , A61K9/19 , A61K31/7105
摘要： The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.
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公开(公告)号：US11433027B2
公开(公告)日：2022-09-06
申请号：US16998259
申请日：2020-08-20
申请人： CureVac AG
发明人： Fabian Johannes Eber , Benyamin Yazdan Panah , Stefanie Sewing , Thomas Ketterer , Thorsten Mutzke , Tilmann Roos , Michael Sonntag , Michael Wiggenhorn , Katharina Kolland
IPC分类号： C07H21/04 , A61K9/16 , A61K48/00 , A61P31/00 , A61P31/12 , A61P37/06 , A61P37/08 , A61P31/04 , A61P33/02 , A61P35/00 , A61K39/145 , A61K39/00
摘要： The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.
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