公开(公告)号：US11179337B2

公开(公告)日：2021-11-23

申请号：US16679536

申请日：2019-11-11

Applicant: CureVac AG

Inventor： Fabian Johannes Eber ,  Benyamin Yazdan Panah ,  Stefanie Sewing ,  Thomas Ketterer ,  Thorsten Mutzke ,  Tilmann Roos ,  Michael Sonntag ,  Michael Wiggenhorn ,  Katharina Kolland

IPC: A61K48/00 ,  A61K9/16 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145 ,  A61K39/00

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US10729654B2

公开(公告)日：2020-08-04

申请号：US15575301

申请日：2016-05-20

Applicant: CureVac AG

Inventor： Fabian Johannes Eber ,  Benyamin Yazdan Panah ,  Stefanie Sewing ,  Thomas Ketterer ,  Thorsten Mutzke ,  Tilmann Roos ,  Michael Sonntag ,  Michael Wiggenhorn ,  Katharina Kolland

IPC: C07H21/04 ,  A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US11279923B2

公开(公告)日：2022-03-22

申请号：US16464152

申请日：2017-11-28

Applicant: CureVac AG

Inventor： Andreas Funkner ,  Stefanie Sewing ,  Isabel Strobel ,  Thorsten Mutzke

IPC: C12N15/10

Abstract: The present invention relates to methods for purifying RNA by chromatography under high salt conditions, e.g. by hydrophobic interaction chromatography.

公开(公告)号：US11534405B2

公开(公告)日：2022-12-27

申请号：US16904993

申请日：2020-06-18

Applicant: CureVac AG

Inventor： Fabian Johannes Eber ,  Benyamin Yazdan Panah ,  Stefanie Sewing ,  Thomas Ketterer ,  Thorsten Mutzke ,  Tilmann Roos ,  Michael Sonntag ,  Michael Wiggenhorn ,  Katharina Kolland

IPC: C07H21/04 ,  A61K9/16 ,  A61K48/00 ,  A61K9/19 ,  A61K31/7105

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-freeze drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.

公开(公告)号：US11433027B2

公开(公告)日：2022-09-06

申请号：US16998259

申请日：2020-08-20

Applicant: CureVac AG

Inventor： Fabian Johannes Eber ,  Benyamin Yazdan Panah ,  Stefanie Sewing ,  Thomas Ketterer ,  Thorsten Mutzke ,  Tilmann Roos ,  Michael Sonntag ,  Michael Wiggenhorn ,  Katharina Kolland

IPC: C07H21/04 ,  A61K9/16 ,  A61K48/00 ,  A61P31/00 ,  A61P31/12 ,  A61P37/06 ,  A61P37/08 ,  A61P31/04 ,  A61P33/02 ,  A61P35/00 ,  A61K39/145 ,  A61K39/00

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.