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公开(公告)号：US10526287B2
公开(公告)日：2020-01-07
申请号：US15567978
申请日：2016-04-22
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC分类号： C07D211/22 , C07D211/26 , C07D309/20 , C07D215/44 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D239/30 , C07C215/44 , C07D417/06 , C07D263/32 , C07D205/12 , C07D207/32 , C07D211/36 , C07D213/64 , C07D305/06 , C07C255/58 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C215/42 , C07C255/30 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/69 , C07D213/73 , C07D295/195 , A61P35/00
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US20180290976A1
公开(公告)日：2018-10-11
申请号：US15567978
申请日：2016-04-22
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Côté , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Rishi G. Vaswani
IPC分类号： C07D211/26 , C07D211/58 , C07C211/40 , C07D213/38 , C07C229/10 , C07D213/73 , C07C255/58 , C07D211/76 , C07D401/06 , C07C215/42 , C07C233/41 , C07C217/08 , C07C237/06 , C07D295/195 , C07C229/38 , C07C255/30 , C07D213/69 , C07D305/06
CPC分类号： C07D211/26 , A61P35/00 , C07B2200/07 , C07C211/09 , C07C211/36 , C07C211/40 , C07C215/14 , C07C215/42 , C07C215/44 , C07C217/08 , C07C229/10 , C07C229/38 , C07C229/46 , C07C233/41 , C07C237/06 , C07C255/24 , C07C255/30 , C07C255/58 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/44 , C07D205/12 , C07D207/32 , C07D211/22 , C07D211/36 , C07D211/58 , C07D211/76 , C07D213/38 , C07D213/64 , C07D213/69 , C07D213/73 , C07D215/44 , C07D239/30 , C07D263/32 , C07D295/195 , C07D305/06 , C07D309/20 , C07D317/28 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D417/06
摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.
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公开(公告)号：US09980952B2
公开(公告)日：2018-05-29
申请号：US15155749
申请日：2016-05-16
发明人： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号： C07D471/04 , A61K31/4545 , C07D401/14 , C07D401/12 , C07D417/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D409/06
CPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20140315949A1
公开(公告)日：2014-10-23
申请号：US14358455
申请日：2012-11-19
发明人： Brian K. Albrecht , James Edmund Audia , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC分类号： C07D213/64 , C07D401/12 , C07D405/12
CPC分类号： C07D213/64 , C07D213/81 , C07D401/12 , C07D405/12
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
摘要翻译： 本文提供了用于调节甲基修饰酶的组合物及其用途。
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公开(公告)号：US20140288123A1
公开(公告)日：2014-09-25
申请号：US14358558
申请日：2012-11-19
发明人： Brian K. Albrecht , James Edmund Audia , Andrew Cook , Alexandre Gagnon , Jean-Christophe Harmange , Christopher G. Nasveschuk
IPC分类号： C07D213/64
CPC分类号： C07D213/64 , C07D221/18 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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公开(公告)号：US20170312252A1
公开(公告)日：2017-11-02
申请号：US15482584
申请日：2017-04-07
发明人： Kwong Wah Lai , Jun Liang , Birong Zhang , Sharada Labadie , Daniel Ortwine , Peter Dragovich , James Kiefer , Victor S. Gehling , Jean-Christophe Harmange
IPC分类号： A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04
CPC分类号： A61K31/41 , A61K31/4025 , C07D207/04 , C07D237/04 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
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公开(公告)号：US09469646B2
公开(公告)日：2016-10-18
申请号：US14839273
申请日：2015-08-28
发明人： Brian K. Albrecht , James Edmund Audia , Les A. Dakin , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号： C07D401/12 , C07D401/14 , C07D487/04 , C07D417/04 , C07D417/14 , C07D405/14 , C07D409/06 , C07D471/04
CPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
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8.发明申请公开(公告)号：US20150376190A1
公开(公告)日：2015-12-31
申请号：US14766632
申请日：2014-02-11
发明人： Brian K. Albrecht , James Edmund Audia , Andrew S. Cook , Les A. Dakin , Martin Duplessis , Victor S. Gehling , Jean-Christophe Harmange , Christopher G. Nasveschuk , Rishi G. Vaswani
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： A61K31/4545 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/06 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.
摘要翻译： 具有用于调节组蛋白甲基修饰酶的结构式（II）的试剂，其组合物和用途，例如作为抗癌剂。
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公开(公告)号：US20140275092A1
公开(公告)日：2014-09-18
申请号：US14209449
申请日：2014-03-13
IPC分类号： C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , A61K31/337 , A61K31/437 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K45/06 , C07D487/14 , C07D498/04 , C12N9/99
摘要： The present invention relates to compounds useful as inhibitors of one or more histone demethylses. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作一种或多种组蛋白脱甲基酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US10577350B2
公开(公告)日：2020-03-03
申请号：US15755854
申请日：2016-08-25
发明人： Brian K. Albrecht , Alisha Arrigo , Donald Corson , Victor S. Gehling , Bruno Patrice Haché , Jean-Christophe Harmange , Jonathan Lane
IPC分类号： C07D401/14
摘要： The present disclosure relates to a crystalline Forms A, B, and C of (R)—N-((4-methoxy-6-methyl-2-oxo-1,2-di-hydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide, each of which are useful as modulators the activity of histone methyl modifying enzymes. The present disclosure also provides pharmaceutically acceptable compositions comprising the crystalline forms and methods of using said compositions in the treatment of various disorders.
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