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公开(公告)号：US20210214795A1
公开(公告)日：2021-07-15
申请号：US17057775
申请日：2019-06-12
发明人： Anthony William DADD , David Andrew GUNN , Taniya KAWATRA , John Chun-Sing NlP , Sheila Alves ROCHA
IPC分类号： C12Q1/6883
摘要： The invention provides a method for obtaining information useful to determine the effect of sun exposure on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg15701237 cg09055205 cg11969813 cg15496956 cg01978213 cg02215357 cg02851203 cg23824183 cg21497990 cg27105183 cg18541042 cg19413397 cg15233074 cg02018681 cg18228590 cg16777510 cg05959430 cg13765278 cg04084883 cg11723713 cg06427571 cg04424885 cg22834542 cg16863522 cg17180088 cg00081714 cg27305903 cg01797450 cg19990373 cg23153745 cg01166892 cg05751344 cg06984848 cg19009417 cg20067575 cg24393844 cg00813560 cg17341765 cg04659582 cg14076239 cg06958636 cg14624145 cg02152631 cg15059474 cg08781365 cg08267250 cg16808156 cg13582226 cg02004370 cg06641366 cg04921068 cg21519787 cg09657114 cg24736734 cg22923895 cg10494639 cg24534872 cg23036668 cg03475509 cg12906649 cg27005906 cg14043049 cg17117459 cg23909173 cg23660755 cg11741189 cg08644276 cg09353052 cg00953443 cg15674181 cg10052164 cg26166717 cg23301462 cg24990283 cg24349610 cg19263548 cg09407650 cg07619697 cg08903441 cg21855021 cg06769820 cg12907959 cg13213009 cg07657776 cg02768671 cg26132737 cg08584947 cg24591969 cg01552275 cg05888872 cg13896748 cg00415971 cg18156845 cg10389644 cg12743638 cg13852284 cg19049964 cg25002649 cg18833788 cg19187110 cg01823161 cg02754084 cg02992048 cg03819134 cg13366863 cg20187049 cg23224396 cg24699871 cg05799507 cg06650378 cg03985520 cg10267724 cg25034941 cg09914773 cg27181375 cg02261047 cg08203794 cg10236596 cg10113820 cg07695089 cg10481072 cg08703857 cg19256731 cg07982208 cg16246713 cg22821554 cg20419272 cg17206555 cg07166800 cg25204319 cg26063719 cg05851505, so that information useful to determine the effect of sun exposure on the skin is obtained.
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公开(公告)号：US20200206173A1
公开(公告)日：2020-07-02
申请号：US16641701
申请日：2018-08-17
发明人： Chenliang Guo , Nan HUANG , Sheila Alves ROCHA
IPC分类号： A61K31/202 , A61K31/232 , A61K31/455 , A61K8/36 , A61K8/37 , A61K8/67 , A61K9/00 , A61K9/107 , A61K8/04 , A61K8/06 , A61P17/00 , A61Q19/00
摘要： The invention relates to a personal care composition, more particularly to a composition for use to reduce or prevent inflammation on a topical surface of a human or animal body. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or an ester thereof and a vitamin B3 compound wherein the mole ratio of the PUFA or ester thereof to the vitamin B3 compound is 1:15 to 1:500.
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公开(公告)号：US20220033902A1
公开(公告)日：2022-02-03
申请号：US17057783
申请日：2019-06-12
发明人： Anthony William DADD , David Andrew GUNN , Taniya KAWATRA , John Chun-Sing NIP , Sheila Alves ROCHA
IPC分类号： C12Q1/6883 , C12Q1/6886
摘要： The invention provides a method for obtaining information useful to determine the effect of the use of sun protection products on the skin of an individual, the method comprising the steps of: (a) obtaining genomic DNA from skin cells derived from the individual, wherein the skin cells include epidermal skin cells; and (b) observing cytosine methylation of at least two CpG loci in the genomic DNA selected from the group consisting of: cg02066936 cg16929393 cg05715751 cg21177821 cg05504117 cg00772091 cg06066180 cg00675160 cg00067720 cg02491003 cg24490133 cg05355684 cg19283806 cg23976431 cg00025972 cg07050101 cg10557907 cg25588389 cg24114899 cg22695351 cg24105685 cg13181164 cg04258138 cg13181974 cg24357619 cg17196051 cg27546066 cg01203651 cg09496748 cg00297912 cg19757573 cg03243551 cg10634273 cg23225508 cg10397765 cg02037307 cg15084618 cg25677261 cg10294853 cg19145082 cg12577010 cg24489344 cg08243465 cg04935109 cg19720260 cg16293892 cg16210355 cg03597159 cg26837962 cg18582260 cg10624914 cg12474705 cg04425614 cg15701237 cg09055205 cg11969813 cg15496956 cg01978213 cg02215357 cg02851203 cg23824183 cg21497990 cg27105183 cg18541042 cg19413397 cg15233074 cg02018681 cg18228590 cg16777510 cg05959430 cg13765278 cg04084883 cg11723713 cg06427571 cg04424885 cg22834542 cg16863522 cg17180088 cg00081714 cg27305903 cg01797450 cg19990373 cg23153745 cg01166892 cg05751344 cg06984848 cg19009417 cg20067575 cg24393844 cg00813560 cg17341765 cg04659582 cg14076239 cg06958636 cg14624145 cg02152631 cg15059474 cg08781365 cg08267250 cg16808156 cg13582226 cg02004370 cg06641366 cg04921068 cg21519787 cg09657114 cg24736734 cg22923895 cg10494639 cg24534872 cg23036668 cg03475509 cg12906649 cg27005906 cg14043049 cg17117459 cg23909173 cg23660755 cg11741189 cg08644276 cg09353052 cg00953443 cg15674181 cg10052164 cg26166717 cg23301462 cg24990283 cg24349610 cg19263548 cg09407650 cg07619697 cg08903441 cg21855021 cg06769820 cg12907959 cg13213009 cg07657776 cg02768671 cg26132737 cg08584947 cg24591969 cg01552275 cg05888872 cg13896748 cg00415971 cg18156845 cg10389644 cg12743638 cg13852284 cg19049964 cg25002649 cg18833788 cg19187110 cg01823161 cg02754084 cg02992048 cg03819134 cg13366863 cg20187049 cg23224396 cg24699871 cg05799507 cg06650378 cg03985520 cg10267724 cg25034941 cg09914773 cg27181375 cg02261047 cg08203794 cg10236596 cg10113820 cg07695089 cg10481072 cg08703857 cg19256731 cg07982208 cg16246713 cg22821554 cg20419272 cg17206555 cg07166800 cg25204319 cg26063719 cg05851505, so that information useful to determine the effect of the use of sun protection products is obtained.
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公开(公告)号：US20220370326A1
公开(公告)日：2022-11-24
申请号：US17623401
申请日：2020-06-23
摘要： Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and S-adenosyl-L-methionine. Use of niacinamide and S-adenosyl-L-methionine in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.
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公开(公告)号：US20220362127A1
公开(公告)日：2022-11-17
申请号：US17623390
申请日：2020-06-23
摘要： Topical personal care compositions for improving cellular energy efficiency by protecting skin from mitochondrial fragmentation that takes place in the cells of an aging individual in need thereof. Use of a topical personal care composition comprising niacinamide and of one or more cooperative skin benefit agents for reducing cellular mitochondrial fragmentation, which cooperative agents are selected from the group consisting of 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof. Use of niacinamide and cooperative skin benefit agent selected from 1-methylnicotinamide chloride, N-acetylmethionine, mixtures thereof, and derivatives thereof in the manufacture of a topical personal care composition for decreasing or preventing mitochondrial fragmentation in skin cells and for increasing skin cellular energy.
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