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    Use of protease inhibitors for treating skin wounds
    1.
    发明授权
    Use of protease inhibitors for treating skin wounds 失效
    使用蛋白酶抑制剂治疗皮肤伤口

    公开(公告)号：US06344189B1

    公开(公告)日：2002-02-05

    申请号：US09190451

    申请日：1998-11-13

    Applicant: Clive Leighton Bunn ,  John Lewis Andrews ,  Phillip John Sharp

    Inventor： Clive Leighton Bunn ,  John Lewis Andrews ,  Phillip John Sharp

    IPC: A61K3174

    CPC classification number: A61K38/06 ,  A61K38/57 ,  Y10S514/944

    Abstract: The healing of chronic wounds, such as leg ulcers, is accelerated via topical administration of a serine protease inhibitor, such as PAI-2. Wound healing also is promoted using combinations of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such inhibitors of metalloproteinases, acid proteases, and thiol proteases, respectively.

    Abstract translation: 通过局部施用丝氨酸蛋白酶抑制剂如PAI-2，加速慢性伤口（例如腿部溃疡）的愈合。 使用蛋白酶抑制剂如PAI-2与其他丝氨酸蛋白酶抑制剂和/或蛋白酶抑制剂分别与金属蛋白酶，酸性蛋白酶和硫醇蛋白酶的抑制剂组合来促进伤口愈合。

    Protease inhibitors for use in the treatment of psoriasis
    2.
    发明授权
    Protease inhibitors for use in the treatment of psoriasis 失效
    用于治疗牛皮癣的蛋白酶抑制剂

    公开(公告)号：US06288025B1

    公开(公告)日：2001-09-11

    申请号：US09368164

    申请日：1999-08-05

    Applicant: Clive Leighton Bunn ,  Phillip John Sharp

    Inventor： Clive Leighton Bunn ,  Phillip John Sharp

    IPC: A61K3800

    CPC classification number: A61K38/57

    Abstract: Psoriasis may be treated by topical administration of a urokinase inhibitor, such as PAI-2, or a combination of protease inhibitors, such as PAI-2 with other serine protease inhibitors and/or with protease inhibitors such as inhibitors of metalloproteinases, acid proteases, and thiol proteases.

    Abstract translation: 牛皮癣可以通过局部施用尿素激酶抑制剂如PAI-2或蛋白酶抑制剂如PAI-2与其它丝氨酸蛋白酶抑制剂和/或与蛋白酶抑制剂如金属蛋白酶抑制剂，酸性蛋白酶， 和硫醇蛋白酶。

    Nematode vaccine
    4.
    发明授权
    Nematode vaccine 失效
    线虫疫苗

    公开(公告)号：US5871738A

    公开(公告)日：1999-02-16

    申请号：US930685

    申请日：1992-10-06

    Applicant: Phillip John Sharp ,  Barry Maxwell Wagland

    Inventor： Phillip John Sharp ,  Barry Maxwell Wagland

    IPC: A61K39/00 ,  A61K39/395 ,  A61P33/00 ,  A61P33/10 ,  C07K14/00 ,  C07K14/435 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C07K1/00

    CPC classification number: C07K16/18 ,  C07K14/4354 ,  A61K39/00 ,  C12N2799/026

    Abstract: Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic nematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.

    Abstract translation: PCT No.PCT / AU92 / 00041 Sec。 371日期：1992年10月6日 102（e）日期1992年10月6日PCT提交1992年2月6日PCT公布。 公开号WO92 / 13890 日期1992年8月20日公开是源自第一寄生线虫物种的基本纯化的抗原，当其施用于宿主动物时，能够通过第二寄生线虫种保护宿主动物免于侵染，其中第一和第二寄生线虫 物种可以相同或不同，并且抗原在还原条件下通过SDS-PAGE测定具有40kD的表观分子量。

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