公开(公告)号：US12178887B2

公开(公告)日：2024-12-31

申请号：US18160202

申请日：2023-01-26

Applicant: CITY OF HOPE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Paul Yazaki ,  Jack Shively ,  Michael Bouvet ,  Jonathan Delong ,  Yuman Fong

IPC: A61K49/00 ,  A61B5/00 ,  A61B6/03 ,  A61B6/40 ,  A61B34/20 ,  A61K39/00 ,  A61K51/10 ,  C07K16/30

Abstract: Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

公开(公告)号：US20230256122A1

公开(公告)日：2023-08-17

申请号：US18145614

申请日：2022-12-22

Applicant: City of Hope

Inventor： John E. Shively ,  Maciej Kujawski ,  Megan Minnix ,  Paul Yazaki

IPC: A61K51/10 ,  A61K47/68 ,  A61P35/00

CPC classification number: A61K51/1048 ,  A61K51/1096 ,  A61K47/6853 ,  A61K47/6813 ,  A61P35/00

Abstract: Provided herein, inter alia, are radionuclide-labeled antibodies, immunocytokines, and methods for treating cancer using combination therapy with the radionuclide-labeled antibodies and the immunocytokines.

公开(公告)号：US20210308184A1

公开(公告)日：2021-10-07

申请号：US17264911

申请日：2019-08-01

Applicant: City of Hope

Inventor： Saul J. Priceman ,  John P. Murad ,  Stephen J. Forman ,  Jack Shively ,  Paul Yazaki ,  David Colcher ,  Anna Kozlowska ,  Hee Jun Lee

IPC: A61K35/17 ,  C07K16/30 ,  C07K14/705 ,  C07K14/715 ,  C07K14/73 ,  C07K14/725 ,  A61P35/00 ,  C12N5/0783

Abstract: Chimeric antigen receptors targeted to TAG72 and the use thereof to treat ovarian cancer and other cancers are described

公开(公告)号：US10758632B2

公开(公告)日：2020-09-01

申请号：US15880454

申请日：2018-01-25

Applicant: CITY OF HOPE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Paul Yazaki ,  Jack Shively ,  Michael Bouvet ,  Jonathan Delong ,  Yuman Fong

IPC: A61K49/00 ,  C07K16/30 ,  A61K51/10 ,  A61B6/00 ,  A61B34/20 ,  A61B5/00 ,  A61B6/03 ,  A61K39/00

Abstract: Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

公开(公告)号：US20230190799A1

公开(公告)日：2023-06-22

申请号：US17870024

申请日：2022-07-21

Applicant: City of Hope

Inventor： John E. Shively ,  Maciej Kujawski ,  Seung E. Cha ,  Paul Yazaki

IPC: A61K35/17 ,  C07K16/30 ,  A61K31/664 ,  A61P35/00 ,  A61P1/00 ,  A61K38/20 ,  A61K38/17 ,  A61K39/395

CPC classification number: A61K35/17 ,  C07K16/3007 ,  A61K31/664 ,  A61P35/00 ,  A61P1/00 ,  A61K38/2013 ,  A61K38/1774 ,  A61K39/39558 ,  C07K2317/622 ,  C07K2317/55 ,  A61K2039/545

Abstract: Aspects of the present disclosure provide methods for treating a subject having a carcinoembryonic antigen (CEA)-positive tumor using a conditioning regimen (lymphodepleting treatment), which comprises administering one or more doses of a lymphodepleting agent to a subject, and a treatment regimen, which comprises administrating one or more doses of the anti-CEA CAR T cells and/or the ICK proteins to the subject.

公开(公告)号：US10479826B2

公开(公告)日：2019-11-19

申请号：US15553532

申请日：2016-02-29

Applicant: CITY OF HOPE

Inventor： Markus Kalkum ,  Karine Bagramyan ,  Paul Yazaki

IPC: C07K16/12 ,  G01N33/53 ,  G01N33/573

Abstract: Provided herein, inter alia, are single chain antibody binding domains (VHHs) for use in conjunction with the Assay with a Large Immuno-sorbent Surface Area (ALISSA). Engineered and affinity matured VHHs are used as affinity reagents in the ALISSA resulting in an exceptionally sensitive and precise method for the detection of toxins at miniscule concentrations. Thus, provided herein are methods as well as reagents that can be used to detect the presence of botulinum neurotoxins in quantities well below 1 pg/mL which corresponds to a lethal concentration under presumed equal distribution throughout the human body.