公开(公告)号：US06291716B1

公开(公告)日：2001-09-18

申请号：US09792108

申请日：2001-02-26

申请人： Chul Ho Jun ,  Jun Bae Hong ,  Kwan Yong Chung ,  Yeon Hee Kim

发明人： Chul Ho Jun ,  Jun Bae Hong ,  Kwan Yong Chung ,  Yeon Hee Kim

IPC分类号： C07C4568

CPC分类号： C07C45/69 ,  C07C45/516 ,  C07F7/083

摘要： An ortho-alkylation method of an aromatic ketone. In the method, as starting materials, the aromatic ketone is reacted with aliphatic or aromatic alkyl moiety-containing olefins in the presence of a primary amine and a transition metal catalyst as reaction catalysts, or ketimines resulting from a reaction of aromatic ketones with a primary amine are reacted with aliphatic or aromatic alkyl moiety-containing olefins in the presence of a transition metal catalyst, thereby introducing the alkyl moiety to the ortho-position of the aromatic ketone.

摘要翻译： 芳香酮的邻位烷基化方法。 在该方法中，作为起始原料，芳族酮在含有伯胺和过渡金属催化剂作为反应催化剂的存在下与含脂肪族或芳香族含烷基部分的烯烃反应，或由芳香族酮与伯 胺在与过渡金属催化剂存在下与脂族或芳族含烷基部分的烯烃反应，从而将烷基部分引入芳族酮的邻位。

公开(公告)号：US06353139B1

公开(公告)日：2002-03-05

申请号：US09792240

申请日：2001-02-26

申请人： Chul Ho Jun ,  Dae Yon Lee ,  Hyuk Lee ,  Jun Bae Hong

发明人： Chul Ho Jun ,  Dae Yon Lee ,  Hyuk Lee ,  Jun Bae Hong

IPC分类号： C07C4569

CPC分类号： C07C45/00 ,  C07F7/083

摘要： A method for preparing ketones has advantages of improving yields and reducing the time of the reactions due to high efficiency of catalysts. Ketones are prepared by reacting an aliphatic or an aromatic aldehyde with a vinyl olefin having an aliphatic or aromatic alkyl moiety in the presence of a transition metal catalyst, 2-aminopyridine catalyst, a primary amine and an acid, as catalysts and additives.

摘要翻译： 制备酮的方法具有提高产率和减少催化剂效率高的反应时间的优点。 酮是通过在过渡金属催化剂，2-氨基吡啶催化剂，伯胺和酸作为催化剂和添加剂的存在下使脂族或芳族醛与具有脂族或芳族烷基部分的乙烯基烯烃反应来制备的。

公开(公告)号：US20090234140A1

公开(公告)日：2009-09-17

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US07767832B2

公开(公告)日：2010-08-03

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/06

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。