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    Organic-inorganic composite
    2.
    发明申请
    Organic-inorganic composite 有权
    有机 - 无机复合材料

    公开(公告)号：US20050126437A1

    公开(公告)日：2005-06-16

    申请号：US10952122

    申请日：2004-09-27

    申请人： Christopher Tagge ,  Jacob Pollock ,  Ken Saito

    发明人： Christopher Tagge ,  Jacob Pollock ,  Ken Saito

    IPC分类号： C04B24/38 ,  C04B28/14 ,  C08L3/04 ,  C08L1/26

    CPC分类号： C04B28/14 ,  C04B24/383 ,  C04B2111/0062 ,  C08L3/04 ,  C04B20/023 ,  C04B14/42

    摘要： An inorganic-organic composite comprises an inorganic phase, such as gypsum crystals, and a film forming organic phase. the film forming organic phase is selected from substituted starches having a degree of polymerization; degree of substitution and viscosity such that the substituted starches are insoluble in water during mixing but dissolve at a higher processing temperature during forming, setting or drying of the composite. Thus, excessive migration of the substitute starch is prevented and the composite is substantially strengthened.

    摘要翻译： 无机 - 有机复合材料包括无机相，例如石膏晶体和成膜有机相。 成膜有机相选自具有聚合度的取代淀粉; 取代度和粘度使得取代的淀粉在混合期间不溶于水，但在复合材料的成型，固化或干燥过程中在较高的加工温度下溶解。 因此，可以防止替代淀粉的过度迁移，并且复合物显着增强。

    Surgical adhesive compostion and process for enhanced tissue closure and healing
    4.
    发明申请
    Surgical adhesive compostion and process for enhanced tissue closure and healing 审中-公开
    手术粘合剂组合和加强组织闭合和愈合的过程

    公开(公告)号：US20070092483A1

    公开(公告)日：2007-04-26

    申请号：US11584140

    申请日：2006-10-20

    申请人： Jacob Pollock

    发明人： Jacob Pollock

    IPC分类号： A61K31/785 ,  C08G63/91

    CPC分类号： A61K31/785

    摘要： A surgical tissue adhesive composition contains at least one 1,1-disubstituted electron-deficient olefin macromer. The adhesive composition of the invention has improved biocompatibility as well as controlled biodegradation characteristics and bioactivity. Adhesive co-monomer compositions contain at least one macromer with a pendant oligomer, polymer, or peptide chain as an acrylic ester of the reactive olefin. The polymers formed therefrom have a grafted brush-like nature. The composition is particularly useful for creating an adhesive bond at the junction of living tissue in surgical applications. The adhesive composition may further comprise co-monomer, co-macromer, cross-linker, or inter-penetrating polymer compounds containing peptide sequences that are bioactive or enzyme responsive. The peptide sequences are selected to promote tissue infiltration and healing in a particular biological tissue. The sequences may contain specific cell-adhesion, cell-signaling, and enzyme-cleavable domains. Furthermore, a degradable filler material may be included in the composition to create a reinforced composite. The filler preferably has a higher degradation rate than the polymer matrix, generating porosity upon degradation. The adhesive may further contain entrapped or incorporated drugs or biologics, including antibiotics or growth factors. The adhesive can be used to bind together the edges of living tissues during surgical procedures. The cured composition provides interfacial bonding and mechanical fixation while promoting tissue infiltration and replacement of the adhesive polymer.

    摘要翻译： 外科组织粘合剂组合物含有至少一种1,1-二取代的电子缺乏烯烃大分子单体。 本发明的粘合剂组合物具有改善的生物相容性以及受控的生物降解特性和生物活性。 粘合剂共聚单体组合物含有至少一种具有侧链低聚物，聚合物或肽链的大分子单体作为反应性烯烃的丙烯酸酯。 由此形成的聚合物具有接枝的刷状特性。 该组合物特别可用于在外科应用中在生物组织的连接处产生粘合剂粘合。 粘合剂组合物可以进一步包含含有生物活性或酶反应性肽序列的共单体，共 - 大分子单体，交联剂或相互穿透的聚合物化合物。 选择肽序列以促进特定生物组织中的组织浸润和愈合。 序列可以包含特异性细胞粘附，细胞信号传导和酶切割结构域。 此外，可以在组合物中包含可降解的填充材料以产生增强的复合材料。 填料优选具有比聚合物基质更高的降解速率，在降解时产生孔隙率。 粘合剂可以进一步包含截留或掺入的药物或生物制剂，包括抗生素或生长因子。 在外科手术过程中，粘合剂可用于将活组织的边缘结合在一起。 固化的组合物提供界面结合和机械固定，同时促进组织浸润和替代粘合剂聚合物。