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公开(公告)号：US09133272B2
公开(公告)日：2015-09-15
申请号：US13409019
申请日：2012-02-29
IPC分类号： C07K16/46 , C07K16/18 , A61K39/395 , C07K16/22 , A61K39/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K2317/31 , C07K2317/64 , C07K2317/76
摘要： The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.
摘要翻译： 本发明涉及双特异性抗硬化蛋白/抗DKK1结合剂以及抗硬化蛋白和抗DKK1结合剂的组合以及相关的治疗方法。
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公开(公告)号：US20080057515A1
公开(公告)日：2008-03-06
申请号：US10448771
申请日：2003-05-28
IPC分类号： G01N33/53 , C07H21/04 , C07K14/575
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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公开(公告)号：US20080188417A1
公开(公告)日：2008-08-07
申请号：US12072855
申请日：2008-02-27
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
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公开(公告)号：US07358341B2
公开(公告)日：2008-04-15
申请号：US10448771
申请日：2003-05-28
IPC分类号： C07K14/575 , C07K14/59
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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5.发明授权Antibodies that specifically bind beta-like glycoprotein hormone polypeptides and heterodimers thereof 失效特异性结合β样糖蛋白激素多肽及其异源二聚体的抗体公开(公告)号：US08278422B2
公开(公告)日：2012-10-02
申请号：US12816475
申请日：2010-06-16
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了10种多肽及其异源二聚体及其编码的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。 还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。
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6.发明授权Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptide and heterodimer thereof 有权编码β样糖蛋白激素多肽的核酸分子及其异二聚体公开(公告)号：US07883868B2
公开(公告)日：2011-02-08
申请号：US12072822
申请日：2008-02-27
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了10种多肽及其异源二聚体及其编码的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。 还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。
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7.发明授权Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof 失效编码β样糖蛋白激素多肽的核酸分子及其异源二聚体公开(公告)号：US07514239B2
公开(公告)日：2009-04-07
申请号：US09818954
申请日：2001-03-27
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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公开(公告)号：US20130164293A1
公开(公告)日：2013-06-27
申请号：US13409019
申请日：2012-02-29
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/18 , C07K2317/31 , C07K2317/64 , C07K2317/76
摘要： The invention relates to bispecific anti-sclerostin/anti-DKK1 binding agents and combinations of anti-sclerostin and anti-DKK1 binding agents, and related methods of treatment.
摘要翻译： 本发明涉及双特异性抗硬化蛋白/抗DKK1结合剂以及抗硬化蛋白和抗DKK1结合剂的组合以及相关的治疗方法。
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公开(公告)号：US07910709B2
公开(公告)日：2011-03-22
申请号：US12072855
申请日：2008-02-27
IPC分类号： C07K14/59
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了10种多肽及其异源二聚体及其编码的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。 还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。
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10.发明申请NUCLEIC ACID MOLECULES ENCODING BETA-LIKE GLYCOPROTEIN HORMONE POLYPEPTIDE AND HETERODIMER THEREOF 失效编码类似谷氨酸激素多聚核苷酸和其它杂环化合物的核酸分子公开(公告)号：US20100255537A1
公开(公告)日：2010-10-07
申请号：US12816475
申请日：2010-06-16
CPC分类号： G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
摘要： Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
摘要翻译： 公开了10种多肽及其异源二聚体及其编码的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。 还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。
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