公开(公告)号：US20190322647A1

公开(公告)日：2019-10-24

申请号：US16390815

申请日：2019-04-22

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Soraya Carrancio ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris ,  Dehua Huang ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Mark A. Nagy ,  Veronique Plantevin-Krenitsky

IPC: C07D403/14 ,  C07D407/14 ,  A61P35/00

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

公开(公告)号：US12103920B2

公开(公告)日：2024-10-01

申请号：US18122496

申请日：2023-03-16

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Matthew D. Correa ,  Deepak Dalvie ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris, III ,  Evan J. Horn ,  Dehua Huang ,  Christopher Mayne ,  Stephen Norris ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Lida Tehrani ,  Brandon W. Whitefield

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: Provided herein are piperidine dione compounds having the following structure:






wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US11739075B2

公开(公告)日：2023-08-29

申请号：US17356305

申请日：2021-06-23

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Matthew D. Correa ,  Deepak Dalvie ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris, III ,  Evan J. Horn ,  Dehua Huang ,  Christopher Mayne ,  Stephen Norris ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Lida Tehrani ,  Brandon W. Whitefield

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: Provided herein are piperidine dione compounds having the following structure:






wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US20240368083A1

公开(公告)日：2024-11-07

申请号：US18521663

申请日：2023-11-28

Applicant: Celgene Corporation

Inventor： Massimo Ammirante ,  Sogole Bahmanyar ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Evan J. Horn ,  Timothy S. Kercher ,  Christopher Mayne ,  Mark A. Nagy ,  Rama Krishna Narla ,  Surendra Nayak ,  Stephen Norris ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Brandon W. Whitefield ,  Shuichan Xu

IPC: C07D211/94 ,  C07D233/30

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US11873283B2

公开(公告)日：2024-01-16

申请号：US17403742

申请日：2021-08-16

Applicant: Celgene Corporation

Inventor： Massimo Ammirante ,  Sogole Bahmanyar ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Evan J. Horn ,  Timothy S. Kercher ,  Christopher Mayne ,  Mark A. Nagy ,  Rama Krishna Narla ,  Surendra Nayak ,  Stephen Norris ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Brandon W. Whitefield ,  Shuichan Xu

IPC: C07D211/94 ,  C07D233/30

CPC classification number: C07D211/94 ,  C07D233/30

Abstract: Provided herein are piperidine dione compounds having the following structure:






wherein RN, R1, R2, R3, R4, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US20230002321A1

公开(公告)日：2023-01-05

申请号：US17403742

申请日：2021-08-16

Applicant: Celgene Corporation

Inventor： Massimo Ammirante ,  Sogole Bahmanyar ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Evan J. Horn ,  Timothy S. Kercher ,  Christopher Mayne ,  Mark A. Nagy ,  Rama Krishna Narla ,  Surendra Nayak ,  Stephen Norris ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Brandon W. Whitefield ,  Shuichan Xu

IPC: C07D211/94 ,  C07D233/30

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US11358952B2

公开(公告)日：2022-06-14

申请号：US16390815

申请日：2019-04-22

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Soraya Carranclo ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris ,  Dehua Huang ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Mark A. Nagy ,  Veronique Plantevin-Krenitsky

IPC: C07D403/14 ,  C07D407/14 ,  C07D491/10 ,  C07D401/04 ,  C07D401/14 ,  C07D417/14 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08 ,  A61P35/00

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

公开(公告)号：US12227490B2

公开(公告)日：2025-02-18

申请号：US18219511

申请日：2023-07-07

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Matthew D. Correa ,  Deepak Dalvie ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris, III ,  Evan J. Horn ,  Dehua Huang ,  Christopher Mayne ,  Stephen Norris ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Lida Tehrani ,  Brandon W. Whitefield

IPC: C07D401/14

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

公开(公告)号：US20220306611A1

公开(公告)日：2022-09-29

申请号：US17743313

申请日：2022-05-12

Applicant: Celgene Corporation

Inventor： Matthew D. Alexander ,  Soraya Carrancio ,  Matthew D. Correa ,  Virginia Heather Sharron Grant ,  Joshua Hansen ,  Roy L. Harris ,  Dehua Huang ,  Timothy S. Kercher ,  Antonia Lopez-Girona ,  Mark A. Nagy ,  Veronique Plantevin-Krenitsky

IPC: C07D403/14 ,  A61P35/00 ,  C07D407/14

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

公开(公告)号：US11325889B2

公开(公告)日：2022-05-10

申请号：US16719217

申请日：2019-12-18

Applicant: Celgene Corporation

Inventor： Massimo Ammirante ,  Sogole Bahmanyar ,  Matthew D. Correa ,  Virginia Grant ,  Joshua Hansen ,  Evan J. Horn ,  Timothy S. Kercher ,  Christopher Mayne ,  Mark A. Nagy ,  Rama Krishna Narla ,  Surendra Nayak ,  Stephen Norris ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  John J. Sapienza ,  Brandon W. Whitefield ,  Shuichan Xu

IPC: C07D211/94 ,  C07D233/86 ,  C07D211/98 ,  C07D233/30

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, X, L, V, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.