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1.发明授权公开(公告)号：US09913875B2
公开(公告)日：2018-03-13
申请号：US15072039
申请日：2016-03-16
发明人： Blake Farrow , James R. Heath , Heather Dawn Agnew
IPC分类号： A61K38/48 , A61K38/55 , C07K14/81 , A61K38/00 , C07B59/00 , A61K47/48 , A61K38/12 , A61K38/06 , C07K7/52 , C07K5/083 , A61K38/08 , C07K7/06 , G01N33/531 , G06F19/12
CPC分类号： A61K38/005 , A61K38/00 , A61K38/06 , A61K38/08 , A61K38/12 , A61K47/60 , C07B59/008 , C07B2200/05 , C07K5/0808 , C07K7/06 , C07K7/08 , C07K7/52 , C07K2319/01 , C07K2319/70 , G01N33/531 , G01N2333/33 , G06F19/12 , Y02A50/469
摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
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2.发明授权公开(公告)号：US11723944B2
公开(公告)日：2023-08-15
申请号：US17322493
申请日：2021-05-17
发明人： Blake Farrow , James R. Heath , Heather Dawn Agnew
IPC分类号： A61K38/00 , C07B59/00 , A61K38/12 , A61K38/06 , C07K7/52 , C07K5/083 , A61K38/08 , C07K7/06 , G01N33/531 , A61K47/60 , C07K7/08 , G16B5/00
CPC分类号： A61K38/005 , A61K38/06 , A61K38/08 , A61K38/12 , A61K47/60 , C07B59/008 , C07K5/0808 , C07K7/06 , C07K7/08 , C07K7/52 , G01N33/531 , A61K38/00 , C07B2200/05 , C07K2319/01 , C07K2319/70 , G01N2333/33 , G16B5/00 , Y02A50/30
摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
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3.发明申请公开(公告)号：US20210369807A1
公开(公告)日：2021-12-02
申请号：US17322493
申请日：2021-05-17
发明人： Blake Farrow , James R. Heath , Heather Dawn Agnew
IPC分类号： A61K38/00 , C07B59/00 , A61K38/12 , A61K38/06 , C07K7/52 , C07K5/083 , A61K38/08 , C07K7/06 , G01N33/531 , A61K47/60 , C07K7/08
摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
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4.发明授权公开(公告)号：US11007245B2
公开(公告)日：2021-05-18
申请号：US15420596
申请日：2017-01-31
发明人： Blake Farrow , James R. Heath , Heather Dawn Agnew
IPC分类号： C07B59/00 , A61K38/00 , A61K38/12 , A61K38/06 , C07K7/52 , C07K5/083 , A61K38/08 , C07K7/06 , G01N33/531 , A61K47/60 , C07K7/08 , G16B5/00
摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
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5.发明申请公开(公告)号：US20170218021A1
公开(公告)日：2017-08-03
申请号：US15420596
申请日：2017-01-31
发明人： Blake Farrow , James R. Heath , Heather Dawn Agnew
CPC分类号： A61K38/005 , A61K38/00 , A61K38/06 , A61K38/08 , A61K38/12 , A61K47/60 , C07B59/008 , C07B2200/05 , C07K5/0808 , C07K7/06 , C07K7/08 , C07K7/52 , C07K2319/01 , C07K2319/70 , G01N33/531 , G01N2333/33 , G16B5/00 , Y02A50/469
摘要： The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.
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公开(公告)号：US20150093758A1
公开(公告)日：2015-04-02
申请号：US14444328
申请日：2014-07-28
IPC分类号： G01N33/574 , C07K14/00
CPC分类号： G01N33/57434 , A61K47/545 , A61K47/551 , C07K7/08 , C07K14/001 , C12N9/6424 , G01N2333/96455
摘要： Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand capture agents containing two or three target-binding moieties, respectively.
摘要翻译： 本文公开了特异性结合PSA的新型合成前列腺特异性抗原（PSA）靶向捕获剂。 在某些实施方案中，这些PSA捕获剂分别是含有两个或三个靶结合部分的双配位体或三配位体捕获剂。
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公开(公告)号：US11733246B2
公开(公告)日：2023-08-22
申请号：US17573941
申请日：2022-01-12
申请人： Indi Molecular, Inc.
IPC分类号： A61K47/65 , G01N33/68 , C07K7/06 , C12N9/02 , G01N33/573
CPC分类号： G01N33/6803 , C07K7/06 , C12N9/0069 , G01N33/573 , C12Y113/11052 , G01N2333/90241
摘要： The present application provides stable heterobiligands made up of peptide-based FOLR1 ligands and folate (the ligand of FOLR1) and methods of use of the heterobiligands as detection, imaging, diagnostic, and therapeutic agents. The application further provides methods of manufacturing FOLR1 heterobiligands, capture agents, and imaging agents.
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公开(公告)号：US20220211648A1
公开(公告)日：2022-07-07
申请号：US17577270
申请日：2022-01-17
申请人： Indi Molecular, Inc.
IPC分类号： A61K31/165 , A61K47/65
摘要： Disclosed are compounds, compositions, systems, and methods useful for treating disease (such as cancer and tumors), or binding, detecting, and affecting compounds, compositions, cells, tissues, and organs, where the compounds, compositions, systems, and methods include or involve toxic compounds and where the toxic effect of the compounds, compositions, systems, and methods is reduced by providing a cleavage site to facilitate separation of the toxic component from other components of the compound, composition, or system. Preferably the system is a composition delivery system comprising or using a composition as disclosed herein. In some forms, the cleavage of the composition delivers a therapeutic agent and avoids organ damage by the composition.
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公开(公告)号：US20180355003A1
公开(公告)日：2018-12-13
申请号：US15721512
申请日：2017-09-29
申请人： Indi Molecular, Inc.
IPC分类号： C07K14/47 , G01N33/573 , G01N33/53 , G01N33/68 , C07K19/00 , G01N33/534 , G01N33/60
CPC分类号： C07K14/47 , A61K38/00 , C07K7/06 , C07K19/00 , C07K2319/01 , C07K2319/60 , C07K2319/70 , G01N33/50 , G01N33/5306 , G01N33/534 , G01N33/573 , G01N33/60 , G01N33/68
摘要： The present application provides stable peptide-based IDO1 capture agents and methods of use as detection, imaging, diagnostic and therapeutic agents. The application further provides methods of manufacturing IDO1 imaging agents.
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公开(公告)号：US20240180856A1
公开(公告)日：2024-06-06
申请号：US18448781
申请日：2023-08-11
申请人： Indi Molecular, Inc.
IPC分类号： A61K31/165 , A61K38/03 , A61K38/06 , A61K38/08 , A61K38/12 , A61K47/65 , A61K51/04 , A61K51/08 , C07B59/00
CPC分类号： A61K31/165 , A61K38/03 , A61K38/06 , A61K38/08 , A61K38/12 , A61K47/65 , A61K51/0495 , A61K51/0497 , A61K51/088 , C07B59/002
摘要： Disclosed are compounds, compositions, systems, and methods useful for treating disease (such as cancer and tumors), or binding, detecting, and affecting compounds, compositions, cells, tissues, and organs, where the compounds, compositions, systems, and methods include or involve toxic compounds and where the toxic effect of the compounds, compositions, systems, and methods is reduced by providing a cleavage site to facilitate separation of the toxic component from other components of the compound, composition, or system. Preferably the system is a composition delivery system comprising or using a composition as disclosed herein. In some forms, the cleavage of the composition delivers a therapeutic agent and avoids organ damage by the composition.
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