公开(公告)号：US11414424B2

公开(公告)日：2022-08-16

申请号：US16557281

申请日：2019-08-30

Applicant: Cytokinetics, Inc.

Inventor： Chihyuan Chuang ,  Bradley P. Morgan ,  Mark Vanderwal ,  Luke W. Ashcraft ,  Kevin Lau

IPC: C07D487/10 ,  A61P9/04 ,  C07D241/08 ,  C07D241/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/08 ,  C07D403/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/08 ,  C07D413/14 ,  C07D417/08 ,  C07D491/107

Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2A, R2B, R3, R4, and R5 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190077793A1

公开(公告)日：2019-03-14

申请号：US16129862

申请日：2018-09-13

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Luke Ashcraft ,  Alessandro Boezio ,  John Butler ,  Aroop Chandra ,  Chihyuan Chuang ,  Scott E. Collibee ,  Mikkel Debenedetto ,  Vincent DiMassa ,  Russell Graceffa ,  Justin Malinowski ,  David Moebius ,  Bradley P. Morgan ,  Joshua Payette ,  Antonio Romero ,  David St. Jean, JR. ,  Richard Vargas ,  John Yeoman ,  Hanmo Zhang

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12 ,  C07D413/14 ,  C07D207/16 ,  C07D209/52 ,  A61P9/00

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US09604965B2

公开(公告)日：2017-03-28

申请号：US14594274

申请日：2015-01-12

Applicant: Cytokinetics, Inc.

Inventor： Luke W. Ashcraft ,  Gustave Bergnes ,  Scott Collibee ,  Chihyuan Chuang ,  Jeff Gardina ,  Bradley P. Morgan ,  Alex R. Muci ,  Xiangping Qian ,  Jeffrey Warrington ,  Zhe Yang ,  Pu-Ping Lu ,  Antonio Romero

IPC: A61K31/50 ,  C07D237/20 ,  C07D401/12 ,  C07D237/24 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D409/14 ,  C07D411/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04 ,  C07D401/14 ,  C07D405/14

CPC classification number: A61K31/50 ,  A61K31/16 ,  A61K31/166 ,  C07D207/26 ,  C07D211/76 ,  C07D213/16 ,  C07D231/56 ,  C07D237/06 ,  C07D237/20 ,  C07D237/24 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D411/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D487/10 ,  C07D513/04 ,  Y02A50/465

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160200717A1

公开(公告)日：2016-07-14

申请号：US14823605

申请日：2015-08-11

Applicant: Cytokinetics, Inc.

Inventor： Luke W. Ashcroft ,  Gustave Bergnes ,  Scott Collibee ,  Chihyuan Chuang ,  Jeff Gardina ,  Bradley P. Morgan ,  Alex R Muci ,  Xiangping Qian ,  Antonio Romero ,  Jeffrey Warrington ,  Zhe Yang

IPC: C07D417/14 ,  C07D213/75 ,  C07D401/14 ,  C07D253/07 ,  C07D403/04 ,  C07D213/74 ,  C07D401/12

CPC classification number: C07D213/74 ,  C07D213/75 ,  C07D213/78 ,  C07D213/82 ,  C07D215/38 ,  C07D215/48 ,  C07D253/07 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/10 ,  C07D417/04 ,  C07D417/14

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R2, R4, R5, R6, R7, R8, R9, X, Z1, Z2, Z3, Z4 and m are as defined herein.Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11472796B2

公开(公告)日：2022-10-18

申请号：US17013472

申请日：2020-09-04

Applicant: Cytokinetics, Inc.

Inventor： Chihyuan Chuang ,  Bradley P. Morgan ,  Mark Vanderwal ,  Wenyue Wang ,  Luke W. Ashcraft

IPC: C07D413/14 ,  A61K31/4245 ,  C07D413/12 ,  A61P9/00 ,  C07D271/06 ,  C07D413/10 ,  C07F5/02 ,  C07D413/04 ,  C07D403/12 ,  C07D417/12 ,  C07D401/12 ,  A61P9/04 ,  C07D231/14

Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R1, R2, R3, G1, G2, and G3 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200223829A1

公开(公告)日：2020-07-16

申请号：US16833321

申请日：2020-03-27

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Luke Ashcraft ,  Alessandro Boezio ,  John Butler ,  Aroop Chandra ,  Chihyuan Chuang ,  Scott E. Collibee ,  Mikkel V. Debenedetto ,  Vincent DiMassa ,  Russell Graceffa ,  Justin Malinowski ,  David Moebius ,  Bradley Paul Morgan ,  Joshua Payette ,  Antonio Romero ,  David St. Jean, JR. ,  Richard Vargas ,  John Yeoman ,  Hanmo Zhang ,  Alan Cheng ,  Felix Gonzalez Lopez De Turiso ,  Michael Garrett Johnson

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  A61P9/00 ,  C07D413/14 ,  C07D207/16 ,  C07D209/52 ,  C07D405/12 ,  C07D417/14 ,  C07D401/06 ,  C07D403/14 ,  C07D209/02 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US20150344472A1

公开(公告)日：2015-12-03

申请号：US14662156

申请日：2015-03-18

Applicant: Global Blood Therapeutics, Inc. ,  Cytokinetics, Inc. ,  The Regents of the University of California

Inventor： Brian Metcalf ,  Chihyuan Chuang ,  Jeffrey Warrington ,  Kumar Paulvannan ,  Matthew P. Jacobson ,  Lan Hua ,  Bradley Morgan

IPC: C07D471/04 ,  C07D215/14 ,  C07D257/04 ,  C07D213/80 ,  C07D211/62 ,  C07D231/56 ,  C07D401/04

CPC classification number: A61K31/4985 ,  A61K31/192 ,  A61K31/235 ,  A61K31/41 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/47 ,  C07C65/30 ,  C07C69/76 ,  C07D211/62 ,  C07D213/30 ,  C07D213/80 ,  C07D215/14 ,  C07D231/56 ,  C07D257/04 ,  C07D401/04 ,  C07D471/04 ,  C07D487/04

Abstract: Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Abstract translation: 提供作为血红蛋白的变构调节剂的取代的苯甲醛及其衍生物，其制备方法和中间体，包含调节剂的药物组合物，及其用于治疗血红蛋白介导的疾病的方法以及将受益于组织氧合增加的病症。

公开(公告)号：US11780826B2

公开(公告)日：2023-10-10

申请号：US17672594

申请日：2022-02-15

Applicant: Amgen Inc. ,  Cytokinetics, Inc.

Inventor： Luke Ashcraft ,  Alessandro Boezio ,  John Butler ,  Aroop Chandra ,  Chihyuan Chuang ,  Scott E. Collibee ,  Mikkel Debenedetto ,  Vincent Dimassa ,  Russell Graceffa ,  Justin Malinowski ,  David Moebius ,  Bradley P. Morgan ,  Joshua Payette ,  Antonio Romero ,  David St. Jean, Jr. ,  Richard Vargas ,  John Yeoman ,  Hanmo Zhang ,  Alan Cheng ,  Felix Gonzalez Lopez De Turiso ,  Michael Garrett Johnson

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  A61P9/00 ,  C07D413/14 ,  C07D207/16 ,  C07D209/52 ,  C07D405/12 ,  C07D417/14 ,  C07D401/06 ,  C07D403/14 ,  C07D209/02 ,  C07D413/12

CPC classification number: C07D403/12 ,  A61P9/00 ,  C07D207/16 ,  C07D209/02 ,  C07D209/52 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US10899746B2

公开(公告)日：2021-01-26

申请号：US16833336

申请日：2020-03-27

Applicant: AMGEN INC. ,  CYTOKINETICS, INC.

Inventor： Luke Ashcraft ,  Alessandro Boezio ,  John Butler ,  Aroop Chandra ,  Chihyuan Chuang ,  Scott E. Collibee ,  Mikkel V. Debenedetto ,  Vincent DiMassa ,  Russell Graceffa ,  Justin Malinowski ,  David Moebius ,  Bradley Paul Morgan ,  Joshua Payette ,  Antonio Romero ,  David St. Jean, Jr. ,  Richard Vargas ,  John Yeoman ,  Hanmo Zhang ,  Alan Cheng ,  Felix Gonzalez Lopez De Turiso ,  Michael Garrett Johnson

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D207/16 ,  C07D405/12 ,  C07D417/14 ,  C07D401/06 ,  C07D403/14 ,  C07D209/02 ,  C07D209/52 ,  A61P9/00 ,  C07D413/12

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US10765624B2

公开(公告)日：2020-09-08

申请号：US16352626

申请日：2019-03-13

Applicant: Cytokinetics, Inc.

Inventor： Zhe Yang ,  Alex R. Muci ,  Jeffrey Warrington ,  Gustave Bergnes ,  Bradley P. Morgan ,  Chihyuan Chuang ,  Antonio Romero ,  Scott Collibee ,  Xiangping Qian ,  Pu-Ping Lu

IPC: A61K9/00 ,  C07D403/04 ,  C07D239/42 ,  C07D513/04 ,  C07D495/04 ,  C07D471/04 ,  C07D417/04 ,  C07D413/14 ,  C07D409/14 ,  C07D401/14 ,  C07D401/12 ,  C07D239/48 ,  C07D403/10 ,  C07D401/04 ,  C07D417/14

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof.Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.