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公开(公告)号：US20200223829A1
公开(公告)日：2020-07-16
申请号：US16833321
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11780826B2
公开(公告)日：2023-10-10
申请号：US17672594
申请日：2022-02-15
Applicant: Amgen Inc. , Cytokinetics, Inc.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent Dimassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
CPC classification number: C07D403/12 , A61P9/00 , C07D207/16 , C07D209/02 , C07D209/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10899746B2
公开(公告)日：2021-01-26
申请号：US16833336
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D413/14 , C07D207/16 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52 , A61P9/00 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US10723720B2
公开(公告)日：2020-07-28
申请号：US16129862
申请日：2018-09-13
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley P. Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D405/12 , C07D413/14 , C07D207/16 , C07D209/52 , A61P9/00 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11299479B1
公开(公告)日：2022-04-12
申请号：US17068518
申请日：2020-10-12
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D413/12 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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Patent Agency Ranking
公开(公告)号：US20200223830A1
公开(公告)日：2020-07-16
申请号：US16833336
申请日：2020-03-27
Applicant: AMGEN INC. , CYTOKINETICS, INC.
Inventor： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson
IPC: C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.
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公开(公告)号：US11407721B2
公开(公告)日：2022-08-09
申请号：US16048677
申请日：2018-07-30
Applicant: AMGEN INC.
Inventor： Michael D. Bartberger , Hilary Plake Beck , Michael R. Degraffenreid , Brian M. Fox , Felix Gonzalez Lopez De Turiso , Lisa D. Julian , Frank Kayser , Julio C. Medina , Steven H. Olson , Yosup Rew , Philip M. Roveto , Daqing Sun , Xuelei Yan
IPC: C07D265/32 , C07D413/06 , C07D487/04 , C07D279/12 , C07D413/04
Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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公开(公告)号：US09873701B2
公开(公告)日：2018-01-23
申请号：US14520899
申请日：2014-10-22
Applicant: AMGEN INC.
Inventor： Yi Chen , Timothy D. Cushing , Jason A. Duquette , Felix Gonzalez Lopez De Turiso , Xiaolin Hao , Xiao He , Brian S. Lucas , Lawrence R. McGee , Andreas Reichelt , Robert M. Rzasa , Jennifer L. Seganish , Youngsook Shin , Dawei Zhang
IPC: C07D487/04 , C07D473/30 , C07D473/34 , C07D471/04
CPC classification number: C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
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公开(公告)号：US20210179560A1
公开(公告)日：2021-06-17
申请号：US16983027
申请日：2020-08-03
Applicant: Amgen Inc.
Inventor： Michael D. Bartberger , Ana Gonzalez Buenrostro , Hilary Plake Beck , Xiaoqi Chen , Richard Victor Connors , Jeffrey Deignan , Jason A. Duquette, I , John Eksterowicz , Benjamin Fisher , Brian M. Fox , Jiasheng Fu , Zice Fu , Felix Gonzalez Lopez De Turiso , Michael W. Gribble , Darin J. Gustin , Julie A. Heath , Xin Huang , XianYun Jiao , Michael G. Johnson , Frank Kayser , David John Kopecky , SuJen Lai , Yihong Li , Zhihong Li , Jiwen Liu , Jonathan D. Low , Brian S. Lucas , Zhihua MA , Lawrence R. McGee , Joel McIntosh , Dustin L. McMinn , Julio C. Medina , Jeffrey Thomas Mihalic , Steven H. Olson , Yossup Rew , Philip M. Roveto , Daqing Sun , Xiaodong Wang , Yingcai Wang , Xuelei Yan , Ming Yu , Jiang Zhu
IPC: C07D211/76 , C07D401/12 , C07D498/14 , C07D409/04 , C07D407/04 , C07D471/10 , C07D401/06 , C07D279/02 , C07D405/04 , C07D417/12 , C07D405/12 , C07D417/06 , C07D221/20 , C07D498/08 , C07D491/153 , C07D498/20 , C07D409/12 , C07D491/08 , C07D417/14 , C07D413/06 , C07D407/06 , C07D401/04
Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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10.发明授权公开(公告)号：US09376425B2
公开(公告)日：2016-06-28
申请号：US14347628
申请日：2012-09-26
Applicant: AMGEN INC.
Inventor： Michael D. Bartberger , Hilary Plake Beck , Xiaoqi Chen , Richard Victor Connors , Jeffrey Deignan , Jason A. Duquette , John Eksterowicz , Brian M. Fox , Jiasheng Fu , Ana Gonzalez Buenrostro , Felix Gonzalez Lopez De Turiso , Darin J. Gustin , Julie A. Heath , Michael G. Johnson , Frank Kayser , David John Kopecky , Yihong Li , Zhihong Li , Zhihua Ma , Joel McIntosh , Julio C. Medina , Jeffrey Thomas Mihalic , Steven H. Olson , Yosup Rew , Philip M. Roveto , Michael J. Schmitt , Daqing Sun , Xiaodong Wang , Malgorzata Wanska , Christine Weathers , Xuelei Yan
IPC: C07D265/06 , C07D413/04 , C07D413/10 , C07D417/04 , C07D413/12 , C07D265/32
CPC classification number: C07D413/04 , C07D265/06 , C07D265/32 , C07D413/10 , C07D413/12 , C07D417/04
Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
Abstract translation: 本发明提供式I或II的MDM2抑制剂化合物或其药学上可接受的盐，其中变量如上所定义，哪些化合物可用作治疗剂，特别是用于治疗癌症。 本发明还涉及含有MDM2抑制剂的药物组合物。
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