公开(公告)号：US11407721B2

公开(公告)日：2022-08-09

申请号：US16048677

申请日：2018-07-30

Applicant: AMGEN INC.

Inventor： Michael D. Bartberger ,  Hilary Plake Beck ,  Michael R. Degraffenreid ,  Brian M. Fox ,  Felix Gonzalez Lopez De Turiso ,  Lisa D. Julian ,  Frank Kayser ,  Julio C. Medina ,  Steven H. Olson ,  Yosup Rew ,  Philip M. Roveto ,  Daqing Sun ,  Xuelei Yan

IPC: C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C07D279/12 ,  C07D413/04

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.