公开(公告)号：US20240400570A1

公开(公告)日：2024-12-05

申请号：US18654554

申请日：2024-05-03

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Jialiang WANG ,  Xiaoran HAN ,  Liqun CHEN

IPC: C07D487/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

公开(公告)号：US20210315999A1

公开(公告)日：2021-10-14

申请号：US17239356

申请日：2021-04-23

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Jialiang WANG ,  Xiaoran HAN ,  Liqun CHEN

IPC: A61K47/54 ,  C07K14/705

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

公开(公告)号：US20240100170A1

公开(公告)日：2024-03-28

申请号：US18043269

申请日：2021-08-27

Applicant: CULLGEN (SHANGHAI), INC.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Jialiang WANG ,  Xiaoran HAN ,  Liqun CHEN ,  Chengwei ZHANG

IPC: A61K47/55 ,  A61K31/4709 ,  A61K47/54 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K47/55 ,  A61K31/4709 ,  A61K47/545 ,  A61K45/06 ,  A61P35/00

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

公开(公告)号：US20230057177A1

公开(公告)日：2023-02-23

申请号：US17496628

申请日：2021-10-07

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Matthew Randolph LEE ,  Xiaoran HAN ,  Liqun CHEN ,  Chengwei ZHANG ,  Jialiang WANG

IPC: A61K47/64 ,  A61K47/54

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

公开(公告)号：US20240246955A1

公开(公告)日：2024-07-25

申请号：US18555139

申请日：2022-04-12

Applicant: CULLGEN (SHANGHAI), INC.

Inventor： Jing LIU ,  Jialiang WANG ,  Xiaoran HAN ,  Ting YANG

IPC: C07D417/14 ,  A61K31/506 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D417/14 ,  A61K31/506 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14

Abstract: Heterobifunctional compounds (e.g., bi-functional small molecule compounds) and compositions comprising one or more of the heterobifunctional compounds are provided. The heterobifunctional compounds are used for the treatment of certain disease in a subject in need thereof. Methods for identifying such heterobifunctional compounds are also presented.

公开(公告)号：US20240197694A1

公开(公告)日：2024-06-20

申请号：US18550345

申请日：2022-03-14

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Matthew Randolph LEE ,  Xiaoran HAN ,  Liqun CHEN ,  Ting YANG ,  Chengwei ZHANG ,  Jialiang WANG

IPC: A61K31/437 ,  A61K31/417 ,  A61K31/4725 ,  C07D233/64 ,  C07D401/12 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K31/417 ,  A61K31/4725 ,  C07D233/64 ,  C07D401/12 ,  C07D471/04

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or modulating a DDB1- and CUL4-associated factor 1 (DCAF1) protein. Further provided herein are ligand-DCAF1 complexes or in vivo modified DCAF1 proteins.

公开(公告)号：US20240066136A1

公开(公告)日：2024-02-29

申请号：US18361422

申请日：2023-07-28

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Matthew Randolph LEE ,  Xiaoran HAN ,  Liqun CHEN ,  Chengwei ZHANG ,  Jialiang WANG

IPC: A61K47/64 ,  A61K47/54

CPC classification number: A61K47/64 ,  A61K47/545

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

公开(公告)号：US20240059671A1

公开(公告)日：2024-02-22

申请号：US18252737

申请日：2021-11-12

Applicant: CULLGEN (SHANGHAI), INC.

Inventor： Jing LIU ,  Liqun CHEN ,  Jialiang WANG ,  Xiaoran HAN ,  Zhaohui WU ,  Ting YANG ,  Chengwei ZHANG

IPC: C07D401/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  C07D417/14

Abstract: This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.

公开(公告)号：US20240050428A1

公开(公告)日：2024-02-15

申请号：US18248035

申请日：2021-10-07

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Jialiang WANG ,  Xiaoran HAN ,  Liqun CHEN ,  Ting YANG ,  Chengwei ZHANG

IPC: A61K31/498 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/5025 ,  A61K31/497 ,  A61K45/06 ,  A61P35/00

CPC classification number: A61K31/498 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/5025 ,  A61K31/497 ,  A61K45/06 ,  A61P35/00

Abstract: This disclosure relates to GSPT1 degrader compounds (e.g. small molecule compounds), compositions comprising one or more of the compounds, and to methods of use the compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such compounds.

公开(公告)号：US20230257380A1

公开(公告)日：2023-08-17

申请号：US17904822

申请日：2021-02-26

Applicant: Cullgen (Shanghai), Inc.

Inventor： Jing LIU ,  Michael Bruno PLEWE ,  Jialiang WANG ,  Xiaoran HAN ,  Liqun CHEN ,  Chengwei ZHANG

IPC: C07D487/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.