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公开(公告)号：US20230093099A1
公开(公告)日：2023-03-23
申请号：US17600808
申请日：2020-04-02
发明人： Michael Bruno PLEWE , Jialiang Wang , Xiaoran Han , Liqun Chen
摘要： This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.
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公开(公告)号：US20210315999A1
公开(公告)日：2021-10-14
申请号：US17239356
申请日：2021-04-23
发明人： Jing LIU , Michael Bruno PLEWE , Jialiang WANG , Xiaoran HAN , Liqun CHEN
IPC分类号： A61K47/54 , C07K14/705
摘要： This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
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公开(公告)号：US20240246955A1
公开(公告)日：2024-07-25
申请号：US18555139
申请日：2022-04-12
发明人： Jing LIU , Jialiang WANG , Xiaoran HAN , Ting YANG
IPC分类号： C07D417/14 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14
CPC分类号： C07D417/14 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/14
摘要： Heterobifunctional compounds (e.g., bi-functional small molecule compounds) and compositions comprising one or more of the heterobifunctional compounds are provided. The heterobifunctional compounds are used for the treatment of certain disease in a subject in need thereof. Methods for identifying such heterobifunctional compounds are also presented.
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公开(公告)号：US20240197694A1
公开(公告)日：2024-06-20
申请号：US18550345
申请日：2022-03-14
发明人： Jing LIU , Michael Bruno PLEWE , Matthew Randolph LEE , Xiaoran HAN , Liqun CHEN , Ting YANG , Chengwei ZHANG , Jialiang WANG
IPC分类号： A61K31/437 , A61K31/417 , A61K31/4725 , C07D233/64 , C07D401/12 , C07D471/04
CPC分类号： A61K31/437 , A61K31/417 , A61K31/4725 , C07D233/64 , C07D401/12 , C07D471/04
摘要： Provided herein are compounds, pharmaceutical compositions, and methods for binding or modulating a DDB1- and CUL4-associated factor 1 (DCAF1) protein. Further provided herein are ligand-DCAF1 complexes or in vivo modified DCAF1 proteins.
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公开(公告)号：US20240066136A1
公开(公告)日：2024-02-29
申请号：US18361422
申请日：2023-07-28
发明人： Jing LIU , Michael Bruno PLEWE , Matthew Randolph LEE , Xiaoran HAN , Liqun CHEN , Chengwei ZHANG , Jialiang WANG
CPC分类号： A61K47/64 , A61K47/545
摘要： Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
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公开(公告)号：US12065442B2
公开(公告)日：2024-08-20
申请号：US17269670
申请日：2019-08-21
发明人： Jing Liu , Liqun Chen
IPC分类号： C07D487/04 , C07D405/14 , C07D417/14 , C07D471/04
CPC分类号： C07D487/04 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Bivalent compounds, compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof are provided. Methods for identifying such bivalent compounds are provided, either.
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公开(公告)号：US11969472B2
公开(公告)日：2024-04-30
申请号：US17239356
申请日：2021-04-23
发明人： Jialiang Wang , Xiaoran Han , Jing Liu , Liqun Chen
IPC分类号： A61K47/54 , C07K14/705
CPC分类号： A61K47/545 , C07K14/705
摘要： This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
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公开(公告)号：US20240100170A1
公开(公告)日：2024-03-28
申请号：US18043269
申请日：2021-08-27
发明人： Jing LIU , Michael Bruno PLEWE , Jialiang WANG , Xiaoran HAN , Liqun CHEN , Chengwei ZHANG
IPC分类号： A61K47/55 , A61K31/4709 , A61K47/54 , A61K45/06 , A61P35/00
CPC分类号： A61K47/55 , A61K31/4709 , A61K47/545 , A61K45/06 , A61P35/00
摘要： Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.
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公开(公告)号：US20230057177A1
公开(公告)日：2023-02-23
申请号：US17496628
申请日：2021-10-07
发明人： Jing LIU , Michael Bruno PLEWE , Matthew Randolph LEE , Xiaoran HAN , Liqun CHEN , Chengwei ZHANG , Jialiang WANG
摘要： Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
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公开(公告)号：US20240335452A1
公开(公告)日：2024-10-10
申请号：US18294717
申请日：2022-08-03
发明人： Jialiang WANG , Jing LIU , Chengwei ZHANG , Ting YANG
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/496 , A61K31/517 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/4545 , A61K31/496 , A61K31/517 , A61P35/00
摘要： Provided are compositions, their combinations, and their uses thereof, for example in treating a cancer, such as a lymphoma. Some embodiments include providing an Enhancer of Zeste Homolog 2 (EZH2) inhibitor and an immunomodulatory drug to a subject having the cancer.
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