公开(公告)号：US20200061193A1

公开(公告)日：2020-02-27

申请号：US16611015

申请日：2018-05-07

申请人： CORNING INCORPORATED

发明人： Theresa Chang ,  Huayun Deng ,  Benjamin Leonard Linchuck ,  Ying Wei ,  Ying Zhang ,  Yue Zhou

IPC分类号： A61K47/36 ,  C08B37/00

摘要： Cross-linked shear-thinning fluids of pectic acid demonstrating increased viscosity with decreasing shear, as well as methods of producing and using the same. A shear-thinning fluid includes an aqueous solution of pectic acid cross-linked by a divalent cation is disclosed. The pectic acid may be present in an amount ranging from about 0.5 to about 3.0% (w/v), the divalent cation may be present at a concentration of from about 0.5 mM to about 7.0 mM, and the viscosity of the shear-thinning fluid increases with decreasing shear. These cross-linked shear-thinning fluids of pectic acid can be utilized for controlled release formulations, cell encapsulation, and 3D printing, and provide for an improved balance between structure fidelity/mechanical stability and cell viability.