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公开(公告)号：US20220111049A1
公开(公告)日：2022-04-14
申请号：US17560830
申请日：2021-12-23
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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2.发明申请COMPOSITION AND METHODS BASED ON NEUTRALIZING ANTIBODIES DELIVERED INTRANASALLY FOR ENHANCED THERAPEUTIC EFFICACY 审中-公开基于中性递送抗体的组合物和方法用于增强治疗效果公开(公告)号：US20170002062A1
公开(公告)日：2017-01-05
申请号：US15268091
申请日：2016-09-16
Applicant: ContraFect Corporation
Inventor： Michael Wittekind , Adam Vigil
CPC classification number: C07K16/1018 , A61K9/0043 , A61K9/007 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/543 , A61K2039/544 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76
Abstract: The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration. The invention provides compositions suitable for intranasal or inhalation treatment and administration. The invention includes methods for treatment or prophylaxis combining intranasal or inhalation administration with intraperitoneal or intravenous administration of antibodies.
Abstract translation: 本发明通过直接向呼吸道施用药剂，特别是中和抗体或其活性片段，包括通过鼻内或吸入给药，提供了治疗或预防病毒，特别是流感病毒的方法。 本发明提供适用于鼻内或吸入治疗和给药的组合物。 本发明包括治疗或预防鼻内或吸入给药与腹膜内或静脉内施用抗体的方法。
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Patent Agency Ranking
公开(公告)号：US11246928B2
公开(公告)日：2022-02-15
申请号：US16674149
申请日：2019-11-05
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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公开(公告)号：US11827693B2
公开(公告)日：2023-11-28
申请号：US14769795
申请日：2014-03-14
Applicant: CONTRAFECT CORPORATION
Inventor： Michael Wittekind , Adam Vigil
CPC classification number: C07K16/1018 , A61K9/007 , A61K9/0043 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/543 , A61K2039/544 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76
Abstract: The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration. The invention provides compositions suitable for intranasal or inhalation treatment and administration. The invention includes methods for treatment or prophylaxis combining intranasal or inhalation administration with intraperitoneal or intravenous administration of antibodies.
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5.发明申请公开(公告)号：US20200054749A1
公开(公告)日：2020-02-20
申请号：US16674149
申请日：2019-11-05
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that hind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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公开(公告)号：US09718875B2
公开(公告)日：2017-08-01
申请号：US15268091
申请日：2016-09-16
Applicant: ContraFect Corporation
Inventor： Michael Wittekind , Adam Vigil
CPC classification number: C07K16/1018 , A61K9/0043 , A61K9/007 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/543 , A61K2039/544 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/76
Abstract: The present invention provides methods for treatment or prophylaxis of viruses, particularly influenza virus, by administration of agents, particularly neutralizing antibodies or active fragments thereof, directly to the respiratory tract, including by intranasal or inhalation administration. The invention provides compositions suitable for intranasal or inhalation treatment and administration. The invention includes methods for treatment or prophylaxis combining intranasal or inhalation administration with intraperitoneal or intravenous administration of antibodies.
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7.发明申请公开(公告)号：US20170189529A1
公开(公告)日：2017-07-06
申请号：US15116106
申请日：2015-02-04
Applicant: CONTRAFECT CORPORATION , TRELLIS BIOSCIENCE, LLC
Inventor： Angeles Estelles , Lawrence M. Kauvar , Adam Vigil , Michael Wittekind
CPC classification number: A61K39/42 , A61K2039/505 , A61K2039/507 , A61K2039/543 , C07K16/1018 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: Antibodies, compositions and methods are provided for treatment and prophylaxis of influenza virus. Antibodies and antigen-binding fragments are provided that bind near the HA0 maturation cleavage site consensus sequence of influenza hemagglutinin A. Antibody compositions, combinations and methods for effective passive immunization across influenza A and B strains are also provided.
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