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公开(公告)号：US11773362B2
公开(公告)日：2023-10-03
申请号：US17244447
申请日：2021-04-29
摘要： Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
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公开(公告)号：US09283241B2
公开(公告)日：2016-03-15
申请号：US13938275
申请日：2013-07-10
申请人： Clemson University
发明人： Agneta Simionescu , Dan Simionescu , James Chow
IPC分类号： A61F2/06 , A61K31/7024 , A61K31/7034 , A61F2/24 , A61F2/82 , A61L27/22 , A61L27/24 , A61L27/36 , A61L27/50 , A61L27/54 , A61K31/7032
CPC分类号： A61K31/7034 , A61F2/24 , A61F2/82 , A61K31/7024 , A61K31/7032 , A61L27/227 , A61L27/24 , A61L27/3633 , A61L27/3683 , A61L27/3687 , A61L27/50 , A61L27/507 , A61L27/54 , A61L2300/216 , A61L2400/18 , A61L2430/20
摘要： Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (PGG). The treated scaffold can become resistant to glycoxidative stress associated with advanced glycation end products (AGEs) that are present in a hyperglycemic environments associated with diabetes mellitus. The treated scaffold can exhibit a reduced increase in stiffness as compared to an untreated scaffold. The treated scaffold can also exhibit reduced inflammation without negatively affecting the ability of the scaffold to remodel in vivo.
摘要翻译： 公开了用酚类化合物处理的医疗装置和用酚类化合物处理装置的方法。 例如，胶原蛋白或弹性蛋白的支架可以用五加仑葡萄糖（PGG）处理。 处理的支架可以变得抵抗存在于与糖尿病相关的高血糖环境中的晚期糖基化终产物（AGEs）所引起的糖氧化应激。 与未处理的支架相比，经处理的支架可显示出刚度减小的增加。 经处理的支架也可以表现出减少的炎症，而不会不利地影响支架在体内重塑的能力。
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公开(公告)号：US20160022420A1
公开(公告)日：2016-01-28
申请号：US14807407
申请日：2015-07-23
申请人： CLEMSON UNIVERSITY
IPC分类号： A61F2/24
CPC分类号： A61F2/2472
摘要： Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
摘要翻译： 描述了可用于夹持天然或合成心脏瓣膜的组织支架。 组织保持器可以包括夹紧机构和弹簧，并且可以相对于施加到夹持在保持器中的组织的压力自动调节。 组织保持器可以可移除地附接到用于处理组织的系统，并且可以提供组织从开发或切除到植入和/或完成测试的完全免提处理。
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公开(公告)号：US11034928B2
公开(公告)日：2021-06-15
申请号：US14807357
申请日：2015-07-23
申请人： CLEMSON UNIVERSITY
摘要： Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).
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公开(公告)号：US20180296342A1
公开(公告)日：2018-10-18
申请号：US16010889
申请日：2018-06-18
IPC分类号： A61F2/24
CPC分类号： A61F2/2472
摘要： Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
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公开(公告)号：US10660754B2
公开(公告)日：2020-05-26
申请号：US16010889
申请日：2018-06-18
IPC分类号： A61F2/24
摘要： Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
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公开(公告)号：US10022225B2
公开(公告)日：2018-07-17
申请号：US14807407
申请日：2015-07-23
申请人： CLEMSON UNIVERSITY
IPC分类号： A61F2/24
摘要： Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
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8.发明申请Modular Bioreactor, Compliance Chamber for a Bioreactor, and Cell Seeding Apparatus 审中-公开模块化生物反应器，用于生物反应器的合规室和细胞播种装置公开(公告)号：US20160024452A1
公开(公告)日：2016-01-28
申请号：US14807357
申请日：2015-07-23
申请人： Clemson University
摘要： Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).
摘要翻译： 生物反应器和生物反应器的组分被描述为可有利地用于研究或植入物的细胞材料的开发和调理。 生物反应器是模块化的，生物反应器的组分可以容易地与替代物组装，以便为细胞材料（例如可植入组织）开发特定的，预定的调节环境。 通过选择多个备选依从室之一，生物反应器可用于调节低压回路（例如，肺心电路）中的组织，并且通过利用替代的顺应性室，生物反应器可以代替地将组织置于高度 压力回路（例如，主动脉心脏电路）。
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公开(公告)号：US20140018909A1
公开(公告)日：2014-01-16
申请号：US13938275
申请日：2013-07-10
申请人： Clemson University
发明人： Agneta Simionescu , Dan Simionescu , James Chow
IPC分类号： A61K31/7034 , A61F2/82 , A61F2/24
CPC分类号： A61K31/7034 , A61F2/24 , A61F2/82 , A61K31/7024 , A61K31/7032 , A61L27/227 , A61L27/24 , A61L27/3633 , A61L27/3683 , A61L27/3687 , A61L27/50 , A61L27/507 , A61L27/54 , A61L2300/216 , A61L2400/18 , A61L2430/20
摘要： Disclosed is a medical device treated with a phenolic compound and a process for treating a device with the phenolic compound. For example, a collagen or elastin-based scaffold can be treated with pentagalloyl glucose (PGG). The treated scaffold can become resistant to glycoxidative stress associated with advanced glycation end products (AGEs) that are present in a hyperglycemic environments associated with diabetes mellitus. The treated scaffold can exhibit a reduced increase in stiffness as compared to an untreated scaffold. The treated scaffold can also exhibit reduced inflammation without negatively affecting the ability of the scaffold to remodel in vivo.
摘要翻译： 公开了用酚类化合物处理的医疗装置和用酚类化合物处理装置的方法。 例如，胶原蛋白或弹性蛋白的支架可以用五加仑葡萄糖（PGG）处理。 处理的支架可以变得抵抗存在于与糖尿病相关的高血糖环境中的晚期糖基化终产物（AGEs）所引起的糖氧化应激。 与未处理的支架相比，经处理的支架可显示出刚度减小的增加。 经处理的支架也可以表现出减少的炎症，而不会不利地影响支架在体内重塑的能力。
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