公开(公告)号：US20190224213A1

公开(公告)日：2019-07-25

申请号：US16318510

申请日：2017-07-20

申请人： CHEMO RESEARCH S.L.

发明人： Enrico COLLI ,  David F. ARCHER

IPC分类号： A61K31/565 ,  A61K31/065 ,  A61K9/02 ,  A61K9/00 ,  A61P15/02

摘要： The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 μg to 100 μg estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 μg to 100 μg of vitamin D equivalent.

公开(公告)号：US20210069210A1

公开(公告)日：2021-03-11

申请号：US16952142

申请日：2020-11-19

申请人： CHEMO RESEARCH S.L.

发明人： Enrico COLLI ,  David F. ARCHER

IPC分类号： A61K31/565 ,  A61K9/02 ,  A61K47/14 ,  A61K9/00 ,  A61K31/59 ,  A61K31/593 ,  A61P15/02 ,  A61K31/065

摘要： The invention relates to vaginal composition comprising a combination of estrogen and vitamin D or a vitamin D analog at a daily dosage delivery of (i) estrogen ranging from 1 μg to 100 μg estrogen of estradiol equivalent and (ii) vitamin D or analog ranging from 7.5 μg to 100 μg of vitamin D equivalent.

公开(公告)号：US20240350415A1

公开(公告)日：2024-10-24

申请号：US18660021

申请日：2024-05-09

申请人： CHEMO RESEARCH, S.L.

发明人： Enrico COLLI

IPC分类号： A61K9/20 ,  A61K31/567 ,  A61K47/26 ,  A61K47/32 ,  A61P15/18

CPC分类号： A61K9/2054 ,  A61K31/567 ,  A61K47/26 ,  A61K47/32 ,  A61P15/18

摘要： The invention relates to a new modified release oral pharmaceutical form comprising 17α-cyanomethyl-17-ß-hydroxyestra-4,9-dien-3-one (dienogest) and 17α-ethinylestradiol (ethynyl estradiol), its method of production and its medical and non-medical uses, in particular its use in contraception.

公开(公告)号：US20240315959A1

公开(公告)日：2024-09-26

申请号：US18605521

申请日：2024-03-14

申请人： Chemo Research, S.L.

发明人： Enrico COLLI ,  Carlos DÍEZ FUERTES

IPC分类号： A61K9/00 ,  A61K31/565 ,  A61K31/57 ,  A61K47/32 ,  A61K47/34

CPC分类号： A61K9/0039 ,  A61K31/565 ,  A61K31/57 ,  A61K47/32 ,  A61K47/34

摘要： The present invention relates to a method for providing contraception in a female subject, comprising continuous intravaginal administration of levonorgestrel of from about 60 μg/day to about 100 μg/day. The invention further relates to a method for treating endometriosis, endometriosis associated pelvic pain (EAPP) and/or dysmenorrhea comprising continuously administering about 60 μg/day to about 160 μg/day of levonorgestrel. Delivery devices, such as, intravaginal rings for putting the methods in practice are also envisaged.

公开(公告)号：US20240350515A1

公开(公告)日：2024-10-24

申请号：US18682824

申请日：2022-08-11

申请人： CHEMO RESEARCH, S.L.

发明人： Enrico COLLI ,  Salustiano PÉREZ

IPC分类号： A61K31/585 ,  A61K9/20

CPC分类号： A61K31/585 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054

摘要： The present invention relates to drospirenone for use in a method for treating endometriosis, endometriosis associated pelvic pain (EAPP) and/or dysmenorrhea, comprising administering drospirenone in a biphasic regimen. The present invention furthermore relates to the use of drospirenone administered in such a biphasic regimen as a contraceptive and for inducing amenorrhea, as well as to a pharmaceutical composition and a kit comprising drospirenone administered in such a biphasic regimen.

公开(公告)号：US20240315958A1

公开(公告)日：2024-09-26

申请号：US18460441

申请日：2023-09-01

申请人： Chemo Research, S.L.

发明人： Enrico COLLI ,  Carlos DÍEZ FUERTES

IPC分类号： A61K9/00 ,  A61K31/565 ,  A61K31/57 ,  A61K47/32 ,  A61K47/34

CPC分类号： A61K9/0039 ,  A61K31/565 ,  A61K31/57 ,  A61K47/32 ,  A61K47/34

摘要： The present invention relates to a method for providing contraception in a female subject, comprising continuous intravaginal administration of levonorgestrel of from about 60 μg/day to about 100 μg/day. The invention further relates to a method for treating endometriosis, endometriosis associated pelvic pain (EAPP) and/or dysmenorrhea comprising continuously administering about 60 μg/day to about 160 μg/day of levonorgestrel. Delivery devices, such as, intravaginal rings for putting the methods in practice are also envisaged.

公开(公告)号：US20240041775A1

公开(公告)日：2024-02-08

申请号：US18021165

申请日：2021-08-13

申请人： CHEMO RESEARCH, S.L.

发明人： Enrico COLLI

IPC分类号： A61K9/20 ,  A61K31/567 ,  A61K47/26 ,  A61K47/32 ,  A61P15/18

CPC分类号： A61K9/2054 ,  A61K31/567 ,  A61K47/26 ,  A61K47/32 ,  A61P15/18

摘要： The invention relates to a new modified release oral pharmaceutical form comprising 17α-cyanomethyl-17-β-hydrox-yestra-4,9-dien-3-one (dienogest) and 17aα-ethinylestradiol (ethynyl estradiol), its method of production and its medical and non-medical uses, in particular its use in contraception.