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公开(公告)号：US09907904B2
公开(公告)日：2018-03-06
申请号：US15490821
申请日：2017-04-18
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14593 , A61M5/158 , A61M5/16804 , A61M2005/14252 , A61M2005/14506 , A61M2005/1583 , A61M2005/1585 , A61M2205/583
摘要： A drug delivery device or patch-like delivery device which employs a spring force and an inclined surface to apply pressure on a fluid reservoir, thereby delivering medicament to a user's body. The slope of the inclined surface may be engineered to control the drug delivery rate. The device may be low profile and wearable, for example in the form of a patch. A visual indicator of the amount of medicament delivered or remaining may be incorporated, for example via a transparent window that shows the progression of an inclined surface as it presses on the reservoir. The device may incorporate mechanisms for automatic extension and retraction of a cannula at the beginning and end of drug delivery. Drug delivery rate may be limited with flow restrictors, and by using a two-reservoir system with a viscous liquid displacing a reservoir containing the medicament.
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公开(公告)号：US5954684A
公开(公告)日：1999-09-21
申请号：US541058
申请日：1995-10-11
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An iontophoretic drug delivery device of the present invention includes a power source and an electrode assembly containing at least two electrodes, in electrical contact with a first reservoir and a second reservoir. The present invention also includes at least three electrodes in a three electrode embodiment, with the third electrode in electrical contact with a third reservoir. In either embodiment, the first reservoir and the second reservoir contain an active agent to be delivered to an applied area of a patient. The present invention also includes in its two electrode embodiment a switch for reversing the flow of current or in its three electrode embodiment a switch for switching the flow of current, so as to reduce sensation. The devices also include a timer for controlling the amount of time the electrical current flows in each direction. In this way, the devices are suitable for use to deliver an active agent to the applied area approximate the first reservoir when the electrical current flows in one direction for a first period of time and to deliver an active agent to the applied area approximate the second reservoir when the electrical current flows in the other direction during a second period of time. Thus, reversing polarity or switching the flow of current between electrodes, and iontophoresing thereunder below the sensation threshold results in sensation anesthesia so that the current can be raised to deliver the drug without sensation.
摘要翻译： 本发明的离子电渗药物输送装置包括电源和包含至少两个与第一储存器和第二储存器电接触的电极的电极组件。 本发明还包括三电极实施例中的至少三个电极，其中第三电极与第三储存器电接触。 在任一实施方案中，第一储存器和第二储存器包含待递送至患者的施用区域的活性剂。 本发明在其两个电极实施例中还包括用于使电流流动或在其三电极实施例中用于切换电流的开关的开关，以便减少感觉。 这些装置还包括用于控制电流在每个方向上流动的时间量的计时器。 以这种方式，当电流在一个方向上流动第一时间段时，这些装置适用于将活性剂递送到施加的区域近似第一储存器，并将活性剂递送到施加的区域，接近第二储存器 当电流在第二时间段期间在另一个方向上流动时，存储器。 因此，反转极性或切换电极之间的电流流动以及低于感觉阈值的离子电导导致感觉麻醉，使得电流可以升高以递送药物而没有感觉。
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公开(公告)号：US5735810A
公开(公告)日：1998-04-07
申请号：US708332
申请日：1996-09-04
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： The present invention relates to a method and device for the iontophoretic delivery of a therapeutic dose range of bisphosphonate to be delivered to a patient over a period of lime to prevent the onset for advancement of osteoporosis and other metabolic bone diseases for a selected period of time.
摘要翻译： 本发明涉及一种用于离子电渗传递治疗剂量范围的二膦酸盐的方法和装置，其在石灰期间递送至患者以防止在选定的时间段内促进骨质疏松症和其它代谢性骨疾病的发生 。
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公开(公告)号：US5320597A
公开(公告)日：1994-06-14
申请号：US652855
申请日：1991-02-08
申请人： Burton H. Sage, Jr. , Carl R. Bock
发明人： Burton H. Sage, Jr. , Carl R. Bock
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/303 , A61N1/0436
摘要： The present invention provides an iontophoretic drug delivery device having electrode renewing features includes a housing having a first electrode, a second electrode, a circuit for providing electrical communication between the first and second electrodes. The circuit is capable of engaging a source of current. Control means is provided for effecting the amount of current passing between the electrodes. A removable electrolyte reservoir is capable of holding electrolyte and removably engaging the housing so that one of the electrodes can contact electrolyte contained within the reservoir. A removable active agent reservoir is capable of holding an active agent for iontophoretic delivery. The active agent reservoir is capable of removably engaging the housing so that the active agent contacts one of the electrodes.The present invention also provides a method for renewing electrodes during delivery of an active agent from an iontophoretic system which comprises at least two electrodes and means for containing an active agent, which method comprises:a) delivering an active agent in connection with a first electrode which completes a circuit with a second electrode in connection with an electrolyte, andb) delivering an active agent from the second electrode by replacing the electrolyte with an active agent in connection with the second electrode and replacing the active agent with an electrolyte in connection with the first electrode.
摘要翻译： 本发明提供一种具有电极更新特征的离子电渗药物输送装置，其包括具有第一电极，第二电极，用于在第一和第二电极之间提供电连通的电路的壳体。 该电路能够接合电流源。 提供控制装置用于实现电极之间的电流通过量。 可拆卸电解质储存器能够保持电解质并且可拆卸地接合壳体，使得电极中的一个可以接触储存器中包含的电解质。 可去除的活性剂储器能够保持用于离子电渗疗法递送的活性剂。 活性剂储存器能够可移除地接合壳体，使得活性剂接触电极之一。 本发明还提供了一种用于在从离子电渗系统递送活性剂期间更新电极的方法，所述离子电渗系统包括至少两个电极和用于容纳活性剂的装置，所述方法包括：a）将与第一电极结合的活性剂递送 其结束了与电解质结合的第二电极的电路，以及b）通过用与第二电极结合的活性剂代替电解质并用与电解质相关的电解质代替活性剂来从第二电极输送活性剂 第一个电极。
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5.发明授权Apparatus and method for the detection and classification of articles using flow cytometry techniques 失效使用流式细胞术技术检测和分类物品的装置和方法
公开(公告)号：US4661913A
公开(公告)日：1987-04-28
申请号：US649449
申请日：1984-09-11
CPC分类号： G06K9/00147 , G01N15/1456 , G06K9/6253
摘要： This invention concerns a flow apparatus and method for the detection of particles in a sample. Particles are moved, substantially one at a time, in a fluid flow stream. An incident beam of illumination is provided so as to be directed at the particles in the flow stream. Data associated with each moving particle as it passes through the beam of illumination is detected. A class of particles is established, these particles having common characteristics based on the data detected from such class of particles. The data is then stored. Such stored data is compared to data detected from sample particles of an unknown class. A determination is then made that particles from the unknown class belong to the established class as a result of matching respective data.
摘要翻译： 本发明涉及用于检测样品中的颗粒的流动装置和方法。 颗粒在流体流动中一次移动，基本上一个。 提供入射光束以便指向流动流中的颗粒。 检测与每个移动粒子通过照射束相关联的数据。 建立了一类颗粒，这些颗粒具有基于从这种类型的颗粒检测的数据的共同特征。 然后存储数据。 将这样的存储数据与从未知类的样本粒子检测的数据进行比较。 因此，作为匹配各个数据的结果，确定来自未知类的粒子属于所建立的类。
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公开(公告)号：US07268859B2
公开(公告)日：2007-09-11
申请号：US10772418
申请日：2004-02-06
CPC分类号： G01F1/7086 , A61M5/1452 , A61M5/16886 , A61M2005/16863 , A61M2205/3306 , A61M2205/3368 , G01F1/7044 , G01F1/7084
摘要： Systems and methods for measuring the flow of a liquid along a conduit are disclosed. A heat source applies thermal energy to a portion of a liquid flowing along a conduit thereby elevating its temperature. A light source generates a first beam that passes through the liquid in the conduit downstream from the position of application of the thermal energy and an optical detector receives this beam in combination with a second beam that is not passed through the liquid in the conduit and measures a change in intensity of a combined beam. The time required for the heated portion of the liquid to move from the point of application of thermal energy to the point at which the beam passes through the liquid is measured. This measured time, along with the distance of separation of the heat source and the optical sensing means permits calculation of the velocity of the liquid in the conduit.
摘要翻译： 公开了用于测量沿导管流动的液体的系统和方法。 热源将热能施加到沿着导管流动的液体的一部分，从而升高其温度。 光源产生第一光束，其通过施加热能位置下游的导管中的液体，并且光学检测器接收该光束与不通过导管中的液体的第二光束并且测量 组合梁的强度变化。 液体的加热部分从热能施加点移动到光束通过液体的点所需的时间被测量。 该测量时间以及热源和光学感测装置的分离距离允许计算导管中液体的速度。
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公开(公告)号：US5730715A
公开(公告)日：1998-03-24
申请号：US665181
申请日：1996-06-14
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A method for preventing the onset or advancement of osteoporosis or other metabolic bone disorders in a patient by iontophoretically administering to the patient an effective amount of a bisphosphonate which would be effective for preventing the onset or advancement of osteoporosis or other bone disorders and wherein the effective amount of bisphosphonate is delivered over a period of from about four (4) hours to about forty-eight (48) hours, at intervals of from about once a week to about twice a year and wherein the effective amount of bisphosphonate also contains an agent capable of chelating calcium.
摘要翻译： 一种通过对患者进行离子电渗治疗来预防骨质疏松症或其他代谢性骨骼疾病发作或进展的方法，该方法有效量地对于预防骨质疏松症或其他骨病发生或进展有效的双膦酸盐，并且其中有效 二膦酸盐的量在约四（4）小时至约四十八（48）小时的时间内以每周约一次至约两次的间隔递送，并且其中双膦酸盐的有效量还含有一种试剂 能螯合钙。
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公开(公告)号：US4950229A
公开(公告)日：1990-08-21
申请号：US412056
申请日：1989-09-25
申请人： Burton H. Sage, Jr.
发明人： Burton H. Sage, Jr.
CPC分类号： A61N1/044 , A61N1/303 , A61N1/0448
摘要： An iontophorectic electrode has a plurality of ion transmitters for establishing electric field lines in an area and a plurality of receivers for accepting ions flowing along the field lines. A plurality of shields are located to resist ion flow between adjacent transmitters and receivers. The transmitters, shields and receivers are in at least a sequence of transmitter, shield, receiver, shield. The electric field lines emanate substantially in one direction and return in substantially the opposite direction. The transmitters and receivers have matrix structures with space to contain ionic medication and electrolyte, respectively. A support for holding a plurality of sequences has current carrying contacts exposed to connect the transmitters and receivers in circuit with a source of electrical power. The preferred method includes establishing an electric field with lines of energy between a plurality of first and second conductors of ions and then passing ions along the energy lines between the conductors. Thereafter the method includes restricting the flow of ions to paths between adjacent first and second conductors and then positioning the first conductors relative to the second conductors so that the energy lines emanate from the first substantially in one direction return to adjacent second conductors in the opposite direction.
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公开(公告)号：US4600302A
公开(公告)日：1986-07-15
申请号：US593470
申请日：1984-03-26
申请人： Burton H. Sage, Jr.
发明人： Burton H. Sage, Jr.
CPC分类号： G01N15/1434 , G01N15/147 , G01N2015/1497 , G01N2201/0631
摘要： A flow cytometry apparatus for determining one or more characteristics of particles or the like flowing in a liquid stream includes a nozzle for generating a liquid flow stream for moving particles therethrough substantially one at a time. An arc lamp provides a beam of incoherent light to illuminate the particles moving in the flow stream. A prism in the light beam modifies non-uniform incoherent light, as provided by said arc lamp, to a more uniform beam of illumination which is directed to the flowing particles. A detector is included for detecting light with respect to each moving particle and for associating the detected light with one or more characteristics of the particles.
摘要翻译： 用于确定在液体流中流动的颗粒等的一个或多个特性的流式细胞仪装置包括用于产生用于每次一个地移动颗粒的液体流的喷嘴。 弧光灯提供非相干光束以照射在流动流中移动的颗粒。 光束中的棱镜将由所述弧光灯提供的非均匀非相干光改变为更均匀的照射光束，其被引导到流动的颗粒。 包括检测器，用于检测相对于每个移动颗粒的光，并将检测到的光与颗粒的一个或多个特性相关联。
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公开(公告)号：US4571388A
公开(公告)日：1986-02-18
申请号：US460144
申请日：1983-01-24
CPC分类号： G01N33/80 , G01N2001/305
摘要： Reticulocytes are stained with thioflavin T for detection in a flow cytometer.
摘要翻译： 用硫代黄素T染色网织红细胞用于流式细胞仪检测。
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