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4 条记录 (耗时 0.013 秒)

    4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions
    2.
    发明授权
    4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions 失效
    4-孕烯衍生物，其制备方法，组合物和治疗炎性病症的方法

    公开(公告)号：US4404200A

    公开(公告)日：1983-09-13

    申请号：US322592

    申请日：1981-11-17

    申请人： Bror A. Thalen ,  Ralph L. Brattsand

    发明人： Bror A. Thalen ,  Ralph L. Brattsand

    IPC分类号： C07J5/00 ,  A61K31/573 ,  A61K31/58 ,  A61P29/00 ,  C07J71/00

    CPC分类号： C07J71/0031 ,  Y10S514/863 ,  Y10S514/887

    摘要： The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents at the carbon atom in position 22, in which formula A is n-propyl or n-butyl and Z is hydroxyl or hydroxyl esterified with a fatty acid with a straight or branched hydrocarbon chain having 1-5 carbon atoms.The invention also refers to a process for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment and control of inflammatory conditions.

    摘要翻译： 本发明涉及具有抗炎活性的化合物，其特征在于立体异构体混合物或R或S型差向异构体形式的式（I）关于位置22处碳原子上取代基的取向 其中式A为正丙基或正丁基，Z为羟基或羟基酯化为具有1-5个碳原子的直链或支链烃链的脂肪酸。 本发明还涉及制备这些化合物的方法，含有一种化合物的药物制剂和用于治疗和控制炎性病症的方法。

    Novel androstane-17.beta.-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
    3.
    发明授权
    Novel androstane-17.beta.-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions 失效
    新型雄甾烷-17β-羧酸酯，其制备方法和中间体，用于治疗炎性病症的组合物和方法

    公开(公告)号：US4820700A

    公开(公告)日：1989-04-11

    申请号：US946658

    申请日：1987-01-05

    申请人： Ralph L. Brattsand ,  Bror A. Thalen

    发明人： Ralph L. Brattsand ,  Bror A. Thalen

    IPC分类号： A61K31/58 ,  A61P5/38 ,  C07J71/00

    CPC分类号： C07J71/0031

    摘要： The invention refers to compounds having anti-inflammatory activity, characterized by the formula ##STR1## in the form of a stereoisomeric mixture or an epimer of the R or S type regarding the orientation of the substituents in the carbon atom at position 20, in which formula the 1,2 position is saturated or is a double bond,X.sub.1 is hydrogen, fluorine, chlorine or bromine,X.sub.2 is hydrogen, fluorine, chlorine or bromine,R.sub.1 is hydrogen or methyl,R.sub.2 is a straight or branched hydrocarbon chain having 1-10 carbon atoms andR.sub.3 is hydrogen or a straight or branched chain alkyl group having 1-12 carbon atoms, a lower alkyl group substituted by 1-5 halogen atoms or an unsubstituted or substituted phenyl or benzyl group,provided that when R.sub.1 is methyl R.sub.2 is a hydrocarbon chain having 2-10 carbon atoms.The invention also refers to a process and intermediates for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment of inflammatory conditions.

    摘要翻译： 本发明涉及具有抗炎活性的化合物，其特征在于式（I）为立体异构体混合物形式或R或S型差向异构体的形式，涉及20位碳原子上取代基的取向 ，其中1,2位饱和或为双键，X1为氢，氟，氯或溴，X2为氢，氟，氯或溴，R1为氢或甲基，R2为直链或支链烃 具有1-10个碳原子的链，R3是氢或具有1-12个碳原子的直链或支链烷基，被1-5个卤素原子取代的低级烷基或未取代或取代的苯基或苄基，条件是当 R1是甲基R2是具有2-10个碳原子的烃链。 本发明还涉及制备这些化合物的方法和中间体，含有一种化合物的药物制剂和治疗炎性病症的方法。