公开(公告)号：US20180156810A1

公开(公告)日：2018-06-07

申请号：US15659811

申请日：2017-07-26

Applicant: Biotium, Inc.

Inventor： Fei MAO ,  Wai-Yee LEUNG ,  Ching-Ying CHEUNG ,  Hye Eun HOOVER

IPC: G01N33/58 ,  C09B23/08 ,  G01N21/64 ,  C09B69/00 ,  C09B57/02 ,  C09B57/00 ,  C09B11/08 ,  C09B23/06 ,  C09B23/01 ,  C09B11/24

CPC classification number: G01N33/582 ,  C09B11/08 ,  C09B11/24 ,  C09B23/0066 ,  C09B23/06 ,  C09B23/083 ,  C09B23/086 ,  C09B57/001 ,  C09B57/02 ,  C09B69/00 ,  G01N21/6428 ,  G01N2021/6439

Abstract: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

公开(公告)号：US20150025222A1

公开(公告)日：2015-01-22

申请号：US14248886

申请日：2014-04-09

Applicant: Biotium, Inc.

Inventor： Fei MAO ,  Wai-Yee LEUNG ,  Ching-Ying CHEUNG ,  Lori Michelle ROBERTS

IPC: C09B1/516 ,  C09B1/51 ,  A61K49/00

CPC classification number: C09B1/516 ,  A61K49/0052 ,  C09B1/501 ,  C09B1/51 ,  C09B1/5155 ,  G01N1/30 ,  G01N21/6428

Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

Abstract translation: 本发明公开了可用作细胞污渍的新的取代的蒽醌染料。 在本发明的某些方面，核染料可用于染色死细胞或固定细胞的细胞核。 本发明的另一方面涉及包含酶底物部分的取代的蒽醌染料，其可由酶转化或切割，使得底物部分的转化或切割导致染料的官能度或光谱性质的可检测变化。

公开(公告)号：US20210102873A1

公开(公告)日：2021-04-08

申请号：US17067569

申请日：2020-10-09

Applicant: Biotium, Inc.

Inventor： Fei MAO ,  Wai-Yee LEUNG ,  Ching-Ying CHEUNG ,  Hye Eun HOOVER

IPC: G01N1/30 ,  G01N33/532 ,  G01N33/58 ,  C09B11/24 ,  C09B57/00 ,  C09B23/08 ,  C09B57/02 ,  C09B23/06 ,  G01N33/533 ,  G01N33/53

Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.

公开(公告)号：US20180143113A1

公开(公告)日：2018-05-24

申请号：US15815035

申请日：2017-11-16

Applicant: Biotium, Inc.

Inventor： Fei MAO ,  Wai-Yee LEUNG ,  Ching-Ying CHEUNG ,  Hye Eun HOOVER

IPC: G01N1/30 ,  G01N33/532 ,  G01N33/53 ,  G01N33/533 ,  G01N33/58 ,  C07K17/06 ,  C07K1/13 ,  G01N33/68

CPC classification number: G01N1/30 ,  C07K1/13 ,  C07K17/06 ,  C09B11/24 ,  C09B23/06 ,  C09B23/083 ,  C09B57/001 ,  C09B57/02 ,  G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/582 ,  G01N33/6854

Abstract: The present invention provides methods, compositions, and kits useful in preparing labeled molecules, which are useful in the detection of binding partners.