公开(公告)号：US09896717B2

公开(公告)日：2018-02-20

申请号：US14272370

申请日：2014-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shawn Hodges ,  Nick Heredia ,  Jonathan Petersen

IPC: G01N33/53 ,  C12Q1/68

CPC classification number: C12Q1/6804 ,  C12Q2537/159 ,  C12Q2561/101 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: The present invention provides methods of detecting an antigen in a sample comprising contacting the sample with affinity agents to form an antigen-affinity agent-label complex, separating the antigen-affinity agent-label complex from uncomplexed components, partitioning label from the separated sample into multiple partitions, and detecting the presence of the label in one or more partitions. Compositions and kits for detecting an antigen in a sample are also provided.

公开(公告)号：US20160273023A1

公开(公告)日：2016-09-22

申请号：US15073388

申请日：2016-03-17

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yann Jouvenot ,  Nick Heredia ,  Viresh Patel ,  Samantha Cooper ,  Jen Berman ,  Eli Hefner

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q2521/313 ,  C12Q2531/125

Abstract: Methods, compositions, and kits are provided for quantifying a number or frequency of double stranded breaks in the genome of a cell or in the genomes of a population of cells.

Abstract translation: 提供了方法，组合物和试剂盒，用于定量细胞基因组或细胞群体的基因组中双链断裂的数量或频率。

公开(公告)号：US10066256B2

公开(公告)日：2018-09-04

申请号：US15073388

申请日：2016-03-17

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yann Jouvenot ,  Nick Heredia ,  Viresh Patel ,  Samantha Cooper ,  Jen Berman ,  Eli Hefner

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12Q1/6809 ,  C12Q1/6827

Abstract: Methods, compositions, and kits are provided for quantifying a number or frequency of double stranded breaks in the genome of a cell or in the genomes of a population of cells.

公开(公告)号：US20160060621A1

公开(公告)日：2016-03-03

申请号：US14749472

申请日：2015-06-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Jeremy Agresti ,  Samantha Cooper ,  George Karlin-Neumann ,  Nick Heredia ,  Ronald Lebofsky

IPC: C12N15/10

CPC classification number: C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6853 ,  C12Q2521/531 ,  C12Q2525/161 ,  C12Q2525/204 ,  C12Q2535/122 ,  C12Q2565/629 ,  C12Q2563/149 ,  C12Q2563/159 ,  C12Q2563/179 ,  C12Q2565/514

Abstract: Methods, compositions, and kits are provided for nucleic acid analysis, including single cell analysis.

Abstract translation: 提供了用于核酸分析的方法，组合物和试剂盒，包括单细胞分析。

公开(公告)号：US20140336068A1

公开(公告)日：2014-11-13

申请号：US14272370

申请日：2014-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Shawn Hodges ,  Nick Heredia ,  Jonathan Petersen

IPC: C12Q1/68

CPC classification number: C12Q1/6804 ,  C12Q2537/159 ,  C12Q2561/101 ,  C12Q2563/143 ,  C12Q2563/149

Abstract: The present invention provides methods of detecting an antigen in a sample comprising contacting the sample with affinity agents to form an antigen-affinity agent-label complex, separating the antigen-affinity agent-label complex from uncomplexed components, partitioning label from the separated sample into multiple partitions, and detecting the presence of the label in one or more partitions. Compositions and kits for detecting an antigen in a sample are also provided.

Abstract translation: 本发明提供检测样品中的抗原的方法，包括使样品与亲和试剂接触以形成抗原亲和试剂 - 标记复合物，将抗原亲和试剂 - 标记复合物与未络合的组分分离，将标记从分离的样品分离成 多个分区，并且检测标签在一个或多个分区中的存在。 还提供了用于检测样品中的抗原的组合物和试剂盒。