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    METHODS FOR CONTINUOUS MEASUREMENT OF BASELINE NOISE IN A FLOW CYTOMETER AND SYSTEMS FOR SAME
    3.
    发明申请
    METHODS FOR CONTINUOUS MEASUREMENT OF BASELINE NOISE IN A FLOW CYTOMETER AND SYSTEMS FOR SAME 有权

    公开(公告)号：US20220091017A1

    公开(公告)日：2022-03-24

    申请号：US17403105

    申请日：2021-08-16

    Applicant: Becton, Dickinson and Company

    Inventor： Peter Mage ,  Lingjie Wei ,  Peter Johnson ,  David A. Roberts ,  Keegan Owsley

    IPC: G01N15/14

    Abstract: Aspects of the present disclosure include methods for determining baseline noise of a photodetector (e.g., in a light detection system of a particle analyzer). Methods according to certain embodiments include irradiating a sample having particles in a flow stream, detecting light with the photodetector from the irradiated flow stream, generating data signals from the detected light and calculating a moving average mean squared error of the generated data signals to determine the baseline of the photodetector. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodetector for practicing the subject methods are also described. Integrated circuits and non-transitory computer readable storage medium are also provided.

    Methods for identifying saturated data signals in cell sorting and systems for same
    4.
    发明授权
    Methods for identifying saturated data signals in cell sorting and systems for same 有权

    公开(公告)号：US11927522B2

    公开(公告)日：2024-03-12

    申请号：US17160989

    申请日：2021-01-28

    Applicant: Becton, Dickinson and Company

    Inventor： David A. Roberts ,  Lingjie Wei ,  Peter Mage

    IPC: G01N15/14 ,  G01N21/64

    CPC classification number: G01N15/1429 ,  G01N21/6428 ,  G01N2015/149 ,  G01N2021/6439

    Abstract: Aspects of the present disclosure include methods for adjusting a particle classification index in response to one or more saturated data signals from light detected from particles in a flow stream. Methods according to certain embodiments include detecting light from particles in a flow stream; generating a plurality of data signals from the detected light; identifying one or more saturated data signals; generating a saturated signal index that corresponds to the identified saturated data signals; and applying the saturated signal index to a particle classification index to generate an adjusted particle classification index. In some embodiments, methods include determining one or more parameters of a particle (e.g., for use in a particle sort decision) by calculating an adjusted spectral unmixing matrix for the fluorescence of the particle that excludes one or more saturated data signals. Systems and integrated circuit devices (e.g., a field programmable gate array) for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

    Methods For Identifying Saturated Data Signals In Cell Sorting And Systems For Same
    7.
    发明公开
    Methods For Identifying Saturated Data Signals In Cell Sorting And Systems For Same 审中-公开

    公开(公告)号：US20240280465A1

    公开(公告)日：2024-08-22

    申请号：US18434335

    申请日：2024-02-06

    Applicant: Becton, Dickinson and Company

    Inventor： David A. Roberts ,  Lingjie Wei ,  Peter Ludington Mage

    IPC: G01N15/1429 ,  G01N15/149 ,  G01N21/64

    CPC classification number: G01N15/1429 ,  G01N21/6428 ,  G01N15/149 ,  G01N2021/6439

    Abstract: Aspects of the present disclosure include methods for adjusting a particle classification index in response to one or more saturated data signals from light detected from particles in a flow stream. Methods according to certain embodiments include detecting light from particles in a flow stream; generating a plurality of data signals from the detected light; identifying one or more saturated data signals; generating a saturated signal index that corresponds to the identified saturated data signals; and applying the saturated signal index to a particle classification index to generate an adjusted particle classification index. In some embodiments, methods include determining one or more parameters of a particle (e.g., for use in a particle sort decision) by calculating an adjusted spectral unmixing matrix for the fluorescence of the particle that excludes one or more saturated data signals. Systems and integrated circuit devices (e.g., a field programmable gate array) for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

    Method for processing and displaying multi-channel spectral histograms and systems for same
    8.
    发明授权
    Method for processing and displaying multi-channel spectral histograms and systems for same 有权

    公开(公告)号：US11761879B2

    公开(公告)日：2023-09-19

    申请号：US17406944

    申请日：2021-08-19

    Applicant: Becton, Dickinson and Company

    Inventor： Christopher J. Wolf ,  David A. Roberts

    IPC: G01N15/14 ,  G01N15/10

    CPC classification number: G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006

    Abstract: Aspects of the present disclosure include methods for processing and displaying multi-channel spectral histograms. Methods according to certain embodiments include obtaining a histogram of cytometric data for a sample, wherein the cytometric data comprises measurements from particles irradiated in the sample flowing in a flow stream, generating the representation of the histogram by encoding the histogram, the encoding comprising: assigning a color to each histogram value in the representation of the histogram, and duplicating each color corresponding to each histogram value in the representation of the histogram a predetermined number of times, and using the representation of the histogram for displaying the histogram. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

    Subsampling Flow Cytometric Event Data
    9.
    发明申请
    Subsampling Flow Cytometric Event Data 有权

    公开(公告)号：US20220317018A1

    公开(公告)日：2022-10-06

    申请号：US17845294

    申请日：2022-06-21

    Applicant: Becton, Dickinson and Company

    Inventor： Jonathan Lin ,  Keegan Owsley ,  David A. Roberts

    IPC: G01N15/14 ,  G06K9/62

    Abstract: Disclosed herein include systems, devices, computer readable media, and methods for subsampling flow cytometric event data. First and second flow cytometric event data can be transformed into a lower-dimensional space, associated with a plurality of bins, and assigned to a first bin and a second bin. Subsampled flow cytometric event data comprising the first flow cytometric event data can be generated. The subsampled flow cytometric event data can comprise the second flow cytometric event data if the first bin and the second bin are different. The subsampled flow cytometric event data may not comprise the second flow cytometric event data if the first bin and the second bin are identical.

    METHOD FOR PROCESSING AND DISPLAYING MULTI-CHANNEL SPECTRAL HISTOGRAMS AND SYSTEMS FOR SAME
    10.
    发明申请
    METHOD FOR PROCESSING AND DISPLAYING MULTI-CHANNEL SPECTRAL HISTOGRAMS AND SYSTEMS FOR SAME 有权

    公开(公告)号：US20220107260A1

    公开(公告)日：2022-04-07

    申请号：US17406944

    申请日：2021-08-19

    Applicant: Becton, Dickinson and Company

    Inventor： Christopher J. Wolf ,  David A. Roberts

    IPC: G01N15/14

    Abstract: Aspects of the present disclosure include methods for processing and displaying multi-channel spectral histograms. Methods according to certain embodiments include obtaining a histogram of cytometric data for a sample, wherein the cytometric data comprises measurements from particles irradiated in the sample flowing in a flow stream, generating the representation of the histogram by encoding the histogram, the encoding comprising: assigning a color to each histogram value in the representation of the histogram, and duplicating each color corresponding to each histogram value in the representation of the histogram a predetermined number of times, and using the representation of the histogram for displaying the histogram. Systems for practicing the subject methods are also provided. Non-transitory computer readable storage mediums are also described.

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