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公开(公告)号：US11617727B2
公开(公告)日：2023-04-04
申请号：US16856176
申请日：2020-04-23
申请人： Bayer HealthCare LLC
发明人： Debanjan Das , Emanuel Vizzotti , Thomas Dann , Renee Nelson , Courtney C. Haynes , Soundarya Vaithianathan , Reginald Bradley , Reinhard Walter , Gerard Meisel
IPC分类号： A61K31/125 , A61K9/00 , A61K9/06 , A61K31/045 , A61K47/10 , A61K47/44
摘要： Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.
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公开(公告)号：US20190282464A1
公开(公告)日：2019-09-19
申请号：US16300289
申请日：2017-05-11
申请人： Stephen BALDWIN , Scott CARPENTER , Heidi GRAHAM , Nanhye KIM , Tom MEYER , David REYNOLDS , Jerry VANCLEAVE , Eric DANN , Thomas DANN , Renee NELSON , Brian DANN , Bayer Healthcare LLC , Formulated Solutions, LLC
发明人： Stephen Baldwin , Scott Carpenter , Heidi Graham , Nanhye Kim , Tom Meyer , David Reynolds , Jerry Vancleave , Eric Dann , Thomas Dann , Renee Nelson , Brian Dann
摘要： The present disclosure relates to, inter alia, a formulation in a package, the formulation comprises one or more active agents and is co-mingled with a whipping agent prior to being filled under pressure into the package. The whipping agent is added in sufficient amounts to be dispersed in the formulation. The pressurized package is under sufficient pressure suitable to maintain the whipping agent dispersed in the formulation; and the pressurized package is under sufficient pressure to expel the formulation as a whipped formulation upon application of external force on the formulation in the package.
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公开(公告)号：US12097186B2
公开(公告)日：2024-09-24
申请号：US16856363
申请日：2020-04-23
申请人： Bayer HealthCare LLC
发明人： Debanjan Das , Emanuel Vizzotti , Thomas Dann , Renee Nelson , Courtney C. Haynes , Soundarya Vaithianathan , Reginald Bradley , Reinhard Walter , Gerard Meisel
IPC分类号： A61K31/277 , A61K31/045 , A61K31/125 , A61K31/4164 , A61K47/44
CPC分类号： A61K31/4164 , A61K31/045 , A61K31/125 , A61K47/44
摘要： Provided are topical analgesic compositions and methods of preparing topical analgesic compositions comprising a stable nano-encapsulating matrix film. The topical analgesic compositions and methods of preparing topical analgesic compositions may be suited for roll-on applicators. Topical analgesic compositions may include 12 to 16 wt. % menthol; 4 to 8 wt. % camphor; 2 to 15 wt. % film-forming polymer; and 50 to 70 wt. % solvent. To be used in a roll-on applicator, the topical analgesic composition has a viscosity from 800 to 1400 centipoise.
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公开(公告)号：US20190282463A1
公开(公告)日：2019-09-19
申请号：US16300270
申请日：2017-05-11
申请人： Stephen BALDWIN , Scott CARPENTER , Heidi GRAHAM , Nanhye KIM , Tom MEYER , David REYNOLDS , Jerry VANCLEAVE , Eric DANN , Thomas DANN , Renee NELSON , Brian DANN , Bayer Healthcare LLC , Formulated Solutions, LLC
发明人： Stephen Baldwin , Scott Carpenter , Heidi Graham , Nanhye Kim , Tom Meyer , David Reynolds , Jerry Vancleave , Eric Dann , Thomas Dann , Renee Nelson , Brian Dann
摘要： The present disclosure relates to, inter alia, a formulation in a package. The formulation comprises one or more active agents and is co-mingled with a whipping agent prior to being filled under pressure into the package. The whipping agent is added in sufficient amounts to be dispersed in the formulation. The pressurized package is under sufficient pressure suitable to maintain the whipping agent dispersed in the formulation; and the pressurized package is under sufficient pressure to expel the formulation as a whipped formulation upon application of external force on the formulation in the package.
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