公开(公告)号：US11617727B2

公开(公告)日：2023-04-04

申请号：US16856176

申请日：2020-04-23

申请人： Bayer HealthCare LLC

发明人： Debanjan Das ,  Emanuel Vizzotti ,  Thomas Dann ,  Renee Nelson ,  Courtney C. Haynes ,  Soundarya Vaithianathan ,  Reginald Bradley ,  Reinhard Walter ,  Gerard Meisel

IPC分类号： A61K31/125 ,  A61K9/00 ,  A61K9/06 ,  A61K31/045 ,  A61K47/10 ,  A61K47/44

摘要： Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.

公开(公告)号：US12097186B2

公开(公告)日：2024-09-24

申请号：US16856363

申请日：2020-04-23

申请人： Bayer HealthCare LLC

发明人： Debanjan Das ,  Emanuel Vizzotti ,  Thomas Dann ,  Renee Nelson ,  Courtney C. Haynes ,  Soundarya Vaithianathan ,  Reginald Bradley ,  Reinhard Walter ,  Gerard Meisel

IPC分类号： A61K31/277 ,  A61K31/045 ,  A61K31/125 ,  A61K31/4164 ,  A61K47/44

CPC分类号： A61K31/4164 ,  A61K31/045 ,  A61K31/125 ,  A61K47/44

摘要： Provided are topical analgesic compositions and methods of preparing topical analgesic compositions comprising a stable nano-encapsulating matrix film. The topical analgesic compositions and methods of preparing topical analgesic compositions may be suited for roll-on applicators. Topical analgesic compositions may include 12 to 16 wt. % menthol; 4 to 8 wt. % camphor; 2 to 15 wt. % film-forming polymer; and 50 to 70 wt. % solvent. To be used in a roll-on applicator, the topical analgesic composition has a viscosity from 800 to 1400 centipoise.