公开(公告)号：US20240082958A1

公开(公告)日：2024-03-14

申请号：US17767840

申请日：2020-10-08

申请人： Bayer HealthCare LLC

发明人： Debanjan Das ,  Reinhard Walter ,  Javier Zumeta Perez ,  Alberto Prior Cabanillas ,  Gerard Meisel ,  Carlos Figueroa ,  Mark David Ford ,  Roland Norman Thurston, Jr.

IPC分类号： B23K26/364

CPC分类号： B23K26/364 ,  B23K2101/04

摘要： The present disclosure is directed to capsules, for example, softgel capsules for oral administration that have on their surface laser etching that penetrates at least partially into the surface of the capsule, reduces the structural integrity of the capsule while preventing exposure of the interior contents to the outside environment, and increases the rate of release of active ingredients contained within.

公开(公告)号：US11911517B2

公开(公告)日：2024-02-27

申请号：US16410599

申请日：2019-05-13

申请人： BAYER HEALTHCARE LLC

发明人： Javier Zumeta Perez ,  Blanca Alvarez Maluenda ,  Maria Pilar Sanz Saiz ,  Maria Elena Iglesias Piñeiro ,  Anthony Bell ,  Reinhard Walter

IPC分类号： A61K9/48 ,  A61K31/09 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/485

CPC分类号： A61K9/4825 ,  A61K9/4866 ,  A61K9/4883 ,  A61K31/09 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/485

摘要： The present disclosure provides for suspension-based pharmaceutical formulations for cold and flu medications, specifically suspension formulations and soft gel capsule dosage forms having reduced size. The present disclosure also provides methods of preparing the suspensions and soft gel capsule dosage forms.

公开(公告)号：US12097186B2

公开(公告)日：2024-09-24

申请号：US16856363

申请日：2020-04-23

申请人： Bayer HealthCare LLC

发明人： Debanjan Das ,  Emanuel Vizzotti ,  Thomas Dann ,  Renee Nelson ,  Courtney C. Haynes ,  Soundarya Vaithianathan ,  Reginald Bradley ,  Reinhard Walter ,  Gerard Meisel

IPC分类号： A61K31/277 ,  A61K31/045 ,  A61K31/125 ,  A61K31/4164 ,  A61K47/44

CPC分类号： A61K31/4164 ,  A61K31/045 ,  A61K31/125 ,  A61K47/44

摘要： Provided are topical analgesic compositions and methods of preparing topical analgesic compositions comprising a stable nano-encapsulating matrix film. The topical analgesic compositions and methods of preparing topical analgesic compositions may be suited for roll-on applicators. Topical analgesic compositions may include 12 to 16 wt. % menthol; 4 to 8 wt. % camphor; 2 to 15 wt. % film-forming polymer; and 50 to 70 wt. % solvent. To be used in a roll-on applicator, the topical analgesic composition has a viscosity from 800 to 1400 centipoise.

公开(公告)号：US11617727B2

公开(公告)日：2023-04-04

申请号：US16856176

申请日：2020-04-23

申请人： Bayer HealthCare LLC

发明人： Debanjan Das ,  Emanuel Vizzotti ,  Thomas Dann ,  Renee Nelson ,  Courtney C. Haynes ,  Soundarya Vaithianathan ,  Reginald Bradley ,  Reinhard Walter ,  Gerard Meisel

IPC分类号： A61K31/125 ,  A61K9/00 ,  A61K9/06 ,  A61K31/045 ,  A61K47/10 ,  A61K47/44

摘要： Provided are topical analgesic gel compositions having relatively high payloads of menthol and camphor by micro-emulsion technology and methods of preparing topical analgesic gel compositions having relatively high payloads of menthol and camphor. Topical analgesic gel compositions may include from 12 to 16 wt. % menthol; from 4 to 8 wt. % camphor; from 0.1 to 2 wt. % carbomer; and 60 to 70 wt. % solvent. Topical analgesic gel compositions can have a viscosity from 60,000 to 110,000 centipoise.