公开(公告)号：US20250034158A1

公开(公告)日：2025-01-30

申请号：US18041470

申请日：2021-08-14

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jonathan L. SESSLER ,  Adam C. SEDGWICK ,  Gregory THIABAUD ,  Jonathan ARAMBULA

IPC: C07D487/22 ,  A61K31/555 ,  A61K41/00 ,  A61K49/22

Abstract: The present disclosure relates to manganese containing texaphyrin compounds of the formula (I). Wherein the variables are as described herein. The present disclosure also provides pharmaceutical compositions of the compounds. Also, provided herein are methods of using the compounds in the treatment of cancer including platinum resistant cancer.

公开(公告)号：US20230113036A1

公开(公告)日：2023-04-13

申请号：US17807245

申请日：2022-06-16

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jonathan L. SESSLER ,  Jonathan ARAMBULA ,  Zahid H. SIDDIK ,  Gregory THIABAUD

IPC: A61K31/555 ,  A61K47/54 ,  A61K47/60 ,  A61K49/08 ,  A61K49/10 ,  C07D487/22 ,  C07F15/00

Abstract: The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer.

公开(公告)号：US20200069698A1

公开(公告)日：2020-03-05

申请号：US16563714

申请日：2019-09-06

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jonathan L. SESSLER ,  Jonathan ARAMBULA ,  Zahid H. SIDDIK ,  Gregory THIABAUD

IPC: A61K31/555 ,  C07D487/22 ,  C07F15/00 ,  A61K47/54 ,  A61K47/60 ,  A61K49/08 ,  A61K49/10

Abstract: The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer.

公开(公告)号：US20170246182A1

公开(公告)日：2017-08-31

申请号：US15317560

申请日：2015-06-11

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jonathan L. SESSLER ,  Jonathan ARAMBULA ,  Zahid H. SIDDIK ,  Gregory THIABAUD

IPC: A61K31/555 ,  C07F15/00 ,  C07D487/22

CPC classification number: A61K31/555 ,  A61K47/546 ,  A61K47/547 ,  A61K47/60 ,  A61K49/085 ,  A61K49/10 ,  A61K49/106 ,  C07D487/22 ,  C07F15/0093

Abstract: The present disclosure relates platinum(IV) and texaphyrin linked conjugates and compositions comprising a texaphyrin and a platinum(IV) agent. The present disclosure also provides pharmaceutical compositions of the conjugates and compositions. Also, provided herein are methods of using the instant compounds in the treatment of cancer such as a platinum resistant cancer.