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公开(公告)号：US10099996B2
公开(公告)日：2018-10-16
申请号：US14025206
申请日：2013-09-12
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： C07C69/614 , A61K31/22 , A61K31/23 , A61K31/235 , A61K31/573 , A61K31/60 , A61K45/06 , C07C69/21 , C07C69/33 , C07C69/533 , C07C69/716 , C07C69/78 , A61K31/191 , A61K31/194 , A61K31/215 , A61K31/575
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
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2.发明申请Compositions And Methods Of Use Of Phorbol Esters For the Treatment Of Stroke 有权佛波尔酯用于治疗中风的组合物和使用方法公开(公告)号：US20150071908A1
公开(公告)日：2015-03-12
申请号：US14025176
申请日：2013-09-12
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： C07C69/33 , C07C69/612 , A61K45/06 , A61K31/22 , C07C69/54 , A61K31/235 , A61K31/216 , C07C69/18 , C07C69/16 , C07C69/78 , A61K31/23
CPC分类号： A61K31/215 , A61K31/216 , A61K31/22 , A61K31/225 , A61K31/23 , A61K31/235 , A61K45/06 , C07C69/16 , C07C69/18 , C07C69/21 , C07C69/33 , C07C69/533 , C07C69/54 , C07C69/612 , C07C69/614 , C07C69/716 , C07C69/78 , C07C2603/40 , A61K2300/00
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
摘要翻译： 提供含有佛波醇酯或佛波醇酯衍生物的方法和组合物用于治疗和预防中风和中风后遗症。 提供了额外的组合物和方法，其使用佛波醇酯或衍生化合物与至少一种另外的试剂组合以产生治疗或预防中风的更有效的治疗工具以及中风在哺乳动物受试者中的长期作用。
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3.发明授权公开(公告)号：US11260041B2
公开(公告)日：2022-03-01
申请号：US14930849
申请日：2015-11-03
发明人： Zheng Tao Han
IPC分类号： A61K31/23 , A61K38/19 , A61K38/18 , A61K31/235 , A61K31/22
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester in combination with G-CSF or in combination with EPO, are provided for the treatment of cytopenia in mammalian subjects. The compositions and methods also reduce the duration of cytopenia such as neutropenia, thrombocytopenia, and/or anemia.
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公开(公告)号：US10882815B2
公开(公告)日：2021-01-05
申请号：US16127315
申请日：2018-09-11
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： A61K31/215 , A61K31/573 , A61K31/60 , C07C69/614 , A61K31/22 , A61K31/23 , A61K31/235 , A61K45/06 , C07C69/21 , C07C69/33 , C07C69/533 , C07C69/716 , C07C69/78 , A61K31/191 , A61K31/194 , A61K31/575
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
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公开(公告)号：US10278934B2
公开(公告)日：2019-05-07
申请号：US15938182
申请日：2018-03-28
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： A61K31/60 , A61K45/06 , A61K31/215 , A61K31/573
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
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公开(公告)号：US10258592B2
公开(公告)日：2019-04-16
申请号：US15658730
申请日：2017-07-25
发明人： Hung-Fong Chen , Zheng Tao Han
IPC分类号： A61K31/23 , A61K31/21 , A61K31/216 , A61K31/235 , A61K31/225 , A61K45/06 , A61K31/573 , A61K31/603 , A61K31/22 , A61K31/381 , A61K31/55
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.
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公开(公告)号：US20180256529A9
公开(公告)日：2018-09-13
申请号：US14025163
申请日：2013-09-12
发明人： Zheng Tao Han , Hung-Fong Chen
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.
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公开(公告)号：US11491131B2
公开(公告)日：2022-11-08
申请号：US16941002
申请日：2020-07-28
发明人： Hung-Fong Chen , Zheng Tao Han
IPC分类号： A61K31/225 , A61K45/06 , A61K31/573 , A61K31/603 , A61K31/22 , A61K31/216 , A61K31/381 , A61K31/55 , A61P25/14 , A61P25/28
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.
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公开(公告)号：US10849871B2
公开(公告)日：2020-12-01
申请号：US15991596
申请日：2018-05-29
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： A61K31/215 , A61K31/23 , A61K31/235 , A61K45/06 , A61K31/22 , A61K31/216 , C07C69/18 , C07C69/21 , C07C69/612 , C07C69/533 , C07C69/33 , A61K31/225
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
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公开(公告)号：US10143672B2
公开(公告)日：2018-12-04
申请号：US15371787
申请日：2016-12-07
发明人： Zheng Tao Han , Hung-Fong Chen
IPC分类号： A61K31/23 , A61K45/06 , A61K31/215 , A61K31/225 , A61K31/22 , C07C69/21 , C07C69/33 , C07C69/612
摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae of stroke. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools to treat or prevent stroke and the long term effects of stroke in mammalian subjects.
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