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    Combating bacteria with 2-methyl-3-carboxylic acid amido-quinoxaline-1,4-di-N-oxides
    1.
    发明授权
    Combating bacteria with 2-methyl-3-carboxylic acid amido-quinoxaline-1,4-di-N-oxides 失效
    与2-甲基-3-羧酸酰氨基 - 喹喔啉-1,4-二-N-氧化物相结合

    公开(公告)号：US3908008A

    公开(公告)日：1975-09-23

    申请号：US28344272

    申请日：1972-08-24

    Applicant: BAYER AG

    Inventor： LEY KURT ,  EHOLZER ULRICH ,  NAST ROLAND ,  METZGER KARL GEORG ,  FRITSCHE DIETER

    IPC: C07D241/52 ,  A61K27/00

    CPC classification number: C07D241/52

    Abstract: Pharmaceutical compositions comprising 2-methyl-3-carboxylic acid-amido-quinoxaline-1,4-di-N-oxides of the formula

    wherein: R1 is hydrogen, lower alkyl, lower alkoxy or chlorine, R2 is hydrogen, straight or branched chain alkyl or straight or branched chain alkyl substituted by hydroxy, lower alkoxy, carbalkoxy, monoalkylamino or dialkylamino, and R3 is straight or branched chain alkyl, straight or branched chain alkyl substituted by hydroxy, lower alkoxy, carbalkoxy, monoalkylamino or dialkylamino, or when R2 is hydrogen, cyclohexyl, or R2 and R3 together with the amido nitrogen atom form part of a 5- or 6- membered heterocyclic ring, IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE INERT CARRIER ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. These compositions or their active compounds can be administered subcutaneously or orally to humans or animals.

    Abstract translation: 包含式OR2的化合物的2-甲基-3-羧酸 - 酰氨基 - 喹喔啉-1,4-二-N-氧化物的药物组合物，其中：

    2 - isothiouronium-methyl - 3 - carboxylic acid amido-quinoxaline - 1,4 - di-n-oxide halides and their production
    2.
    发明授权
    2 - isothiouronium-methyl - 3 - carboxylic acid amido-quinoxaline - 1,4 - di-n-oxide halides and their production 失效
    2-异丙基-3-甲氧基亚氨基 - 喹喔啉-1,4-二氧化氮铪及其生产

    公开(公告)号：US3598820A

    公开(公告)日：1971-08-10

    申请号：US3598820D

    申请日：1968-10-02

    Applicant: BAYER AG

    Inventor： LEY KURT ,  EHOLZER ULRICH ,  NAST ROLAND ,  METZGER KARL-GEORG ,  FRITSCHE DIETER

    IPC: C07D241/52 ,  C07D51/78

    CPC classification number: C07D241/52

    Abstract: 2-ISOTHIOURONIUM-METHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE-1,4-DI-N-OXIDE HALIDES OF THE FORMULA:

    (R1-,1,4-DI-O-,2-R2-N(-R3)-CO-,3-H2N-C(=NH2(+))-S-CH2-

    QUINAZOLINE)(+) HAL(-) (I)

    WHEREIN

    R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE, R2 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS HYDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FORM PART OF A 5- OR 6-MENBERED HETEROCYCLIC RING, AND HAL IS CHLORINE OR BROMINE,

    ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOUNDS MAY BE PRODUCED, INTER ALIA, BY REACTING A 2-HALOMETHYL3-CARBOXYLIC ACID AMIDO-QUIOXALINE-1,4-DI-N-OXIDE OF THE FORMULA:

    R1-,1,4-DI-O
    WITH THIOUREA, WHEREIN R1, R2, R3 AND HAL ARE AS ABOVE DEFINED.

    Abstract translation: 2-异硫脲鎓 - 甲基-3-羧酸 - 酰氨基喹喔啉-1,4-二-N-氧化物的下式：

    Preparation of quinoxaline-di-n-oxides
    3.
    发明授权
    Preparation of quinoxaline-di-n-oxides 失效
    喹诺酮二氧化氮的制备

    公开(公告)号：US3660398A

    公开(公告)日：1972-05-02

    申请号：US3660398D

    申请日：1970-04-07

    Applicant: BAYER AG

    Inventor： LEY KURT ,  EHOLZER ULRICH ,  SENG FLORIN ,  NAST ROLAND

    IPC: C07D241/52 ,  C07D51/78

    CPC classification number: C07D241/52

    Abstract: QUINOXALINE-DI-N-OXIDES, HAVING PHARMACOLOGICAL PROPERTIES AND USABLE AS INTERMEDIATES FOR PRODUCTING PLANT PROTECTING AGENTS, PRODUCED BY REACTING IN AN ORGANIC DILUENT (E.G. AT 20-100*C.) BENZOFURAZANE-N-OXIDE (OPTIONALLY SUBSTITUTED WITH HALO, ALKYL, ALKOXY, ACYL, SUBSTITUTED ACYL, AMIDO, SUBSTITUTED AMIDO, SULFONAMIDO, AND/ OR SUBSTITUTED SULFONAMIDO)WITH A REAGENT COMPOSED OF EITHER (A) AT LEAST AN EQUIVALENT QUANTITY OF BOTH AN ORGANIC CARBONYL COMPOUND (E.G. LINERR OR CYLCLO ALIPHATIC, ARYL, OR HETEROCYCLIC CARBONYL COMPOUND) WITH IS OPTIONALLY SUBSTITUTED AND WHICH CONTAINS THE LINKAGE

    -CH2-CO-

    AND A PRIMARY ALIPHATIC AMINE OR AMMONIA; OR (B) AT LEAST AN EQUIVALENT QUANTITY OF THE CORRESPONDING SCHIFF''S BASE TO THE REAGENT UNDER (A).

    2-methyl - 3 - carboxylic acid amido-quinoxaline-1 4-di-n-ozides and their production
    4.
    发明授权
    2-methyl - 3 - carboxylic acid amido-quinoxaline-1 4-di-n-ozides and their production 失效
    2-甲基-3-羧酸亚氨基 - 喹喔啉-1,4-二-O-氧化物及其生产

    公开(公告)号：US3660391A

    公开(公告)日：1972-05-02

    申请号：US3660391D

    申请日：1968-10-02

    Applicant: BAYER AG

    Inventor： LEY KURT ,  EHOLZER ULRICH ,  NAST ROLAND ,  METZGER KARL GEORG ,  FRITSCHE DIETER

    IPC: C07D241/52 ,  C07D51/78

    CPC classification number: C07D241/52

    Abstract: 2-METHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE - 1,4-DIN-OXIDES OF THE FORMULA:

    1,4-DI(O=),2-CH3,3-(R2-N(-R3)-OC-),R1-QUINOXALINE

    WHEREIN: R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE, R2 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, CARBALKOXY, MONOALKYLAMINO OR DIALKYLAMINO, AND R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, CARBALKOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS IS HYDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FORM PART OF A 5OR 6-MEMBERED HETEROCYCLIC RING, ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOUNDS MAY BE PRODUCED, INTER ALIA, BY REACTING A BENZOFUROXAN OF THE FORMULA:

    1-(O=),R1-BENZOFURAZAN

    WITH AN ACETOACETIC ACID AMIDE OF THE FORMULA:

    CH3-CO-CH2-CO-N(-R2)-R3

    WHEREIN R1, R2 AND R3 ARE AS ABOVE DEFINED.

    Stabilized polyurethanes
    7.
    发明授权
    Stabilized polyurethanes 失效
    稳定的聚氨酯

    公开(公告)号：US3642669A

    公开(公告)日：1972-02-15

    申请号：US3642669D

    申请日：1969-09-04

    Applicant: BAYER AG

    Inventor： NAST ROLAND ,  OERTEL HARALD ,  LEY KURT

    IPC: C08K5/13 ,  C08K5/3475 ,  C08G41/00 ,  C08G51/58 ,  C08G51/60

    CPC classification number: C08K5/13 ,  C08K5/3475 ,  Y10S528/906 ,  C08L75/04

    Abstract: AS STABILIZERS AND FURTEHERMORE TO STABILIZED POLYURETHANES BEING STABILIZED WITH A SYNERGISTIC MIXUTRE CONSISTING OF A) AN ANISOLE AND B) A 2-(2''-HYDROXYPHENYL)-BENZOTRIAZOLE.

    2-((2-(CH3-O-)PHENYL)-CH2-),6-(TERT ALKYL-)PHENOL

    THE INVENTION RELATES TO STABILIZED POLYURETHANES, ESPECAILLY PLYURETHANE ELASTOMER THREADS AND FOILS, AGAINST DEGARADTATION AND DISCLORATIN CAUSED BY THE ACTION OF LIGHT OR UV RADIATION, OXYGEN, SUBSTANCES PRESENT IN THE ATMOSPHERE, SUCH AS NITROGEN OXIDES, AND HEAT BY THE ADDITION OF ALKOXY SUBSTITUTED, STERICALLY HINDERED PHENOLS WHICH HAVE A 2-(2''-HYDROXY-3''-TERTIARY ALKYL BENZYL)-ANISOLE UNIT:

    Hydrazones
    10.
    发明授权
    Hydrazones 失效
    HYDRAZONES

    公开(公告)号：US3689554A

    公开(公告)日：1972-09-05

    申请号：US3689554D

    申请日：1969-08-15

    Applicant: BAYER AG

    Inventor： LEY KURT ,  ROOS ERNST ,  KAMPERMANN THEO ,  NAST ROLAND

    IPC: C08K5/30 ,  C07C109/18

    CPC classification number: C07C251/72 ,  C08K5/30 ,  C08L9/06

    Abstract: Compounds of the formula

    WHEREIN R1 is hydrogen or methyl, n is 0 or 1 and R2 is

    WHEREIN R'' is hydrogen or methyl and m is 0 or 1 and their utility as anti-ozonants in natural and synthetic rubbers.

    Abstract translation: 式WHEREIN R1的化合物是氢或甲基，n是0或1，R2是WHEREIN R'是氢或甲基，m是0或1，并且它们在天然和合成橡胶中作为抗臭氧剂的用途。

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