公开(公告)号：US20170196810A1

公开(公告)日：2017-07-13

申请号：US15472136

申请日：2017-03-28

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Trevor Petrel ,  Craig Bartling ,  Lena Furci ,  Carrie Howland

IPC分类号： A61K9/16 ,  B01F3/08 ,  B01J2/06 ,  B01F5/06 ,  B01F13/08 ,  A61K38/44 ,  B01F5/00

CPC分类号： A61K9/16 ,  A61K9/1682 ,  A61K9/1688 ,  A61K38/443 ,  B01F3/0853 ,  B01F3/0861 ,  B01F5/0057 ,  B01F5/0606 ,  B01F13/08 ,  B01F2215/0032 ,  B01J2/06 ,  C07K1/1136 ,  C12Y101/03004

摘要： Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.

公开(公告)号：US20140288282A1

公开(公告)日：2014-09-25

申请号：US14356367

申请日：2012-11-02

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Trevor Petrel ,  Craig Bartling ,  Lena Furci ,  Carrie Howland

IPC分类号： C07K1/113

CPC分类号： A61K9/16 ,  A61K9/1682 ,  A61K9/1688 ,  A61K38/443 ,  B01F3/0853 ,  B01F3/0861 ,  B01F5/0057 ,  B01F5/0606 ,  B01F13/08 ,  B01F2215/0032 ,  B01J2/06 ,  C07K1/1136 ,  C12Y101/03004

摘要： Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.

摘要翻译： 公开了在环境条件下生产生物活性，富含蛋白质的微粒的方法和装置。 将蛋白质溶液雾化并收集在正在混合的脱水溶剂中。 所得蛋白质微粒保留高比活性，而不需要大量的稳定赋形剂。

公开(公告)号：US09643996B2

公开(公告)日：2017-05-09

申请号：US14356367

申请日：2012-11-02

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Trevor Petrel ,  Craig Bartling ,  Lena Furci ,  Carrie Howland

IPC分类号： A61K45/00 ,  A61L33/12 ,  C07K1/113 ,  A61K9/16

CPC分类号： A61K9/16 ,  A61K9/1682 ,  A61K9/1688 ,  A61K38/443 ,  B01F3/0853 ,  B01F3/0861 ,  B01F5/0057 ,  B01F5/0606 ,  B01F13/08 ,  B01F2215/0032 ,  B01J2/06 ,  C07K1/1136 ,  C12Y101/03004

摘要： Processes and apparatuses for producing biologically-active, protein-rich microparticles under ambient conditions are disclosed. A protein solution is atomized and collected in a dehydration solvent that is being mixed. The resulting protein microparticles retain high specific activity without the need for large amounts of stabilizing excipients.