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    Novel Enzymes, Enzyme Components and Uses Thereof
    1.
    发明申请
    Novel Enzymes, Enzyme Components and Uses Thereof 有权
    新型酶，酶组分及其用途

    公开(公告)号：US20150203826A1

    公开(公告)日：2015-07-23

    申请号：US14416981

    申请日：2013-07-30

    Applicant: BASF Plant Science Company GmbH ,  BASF (CHINA) COMPANY LIMITED

    Inventor： Laurent Marty ,  Toralf Senger

    IPC: C12N9/02 ,  C12P7/64

    CPC classification number: C12N9/0071 ,  C12N9/001 ,  C12P7/6427 ,  C12Y114/19

    Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing said nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.

    Abstract translation: 本发明提供了编码来自Thraustochytrium aureum和Sphaeroforma arctica的新型脂肪酸去饱和酶，KCS，KCR和/或LACS的核酸分子。 本发明还提供含有所述核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及用于大规模生产长链多不饱和脂肪酸（LCPUFA）的方法，例如ARA，EPA和DHA，以及用于 筛选Δ-4去饱和酶。

    Modification of plant lipids containing PUFAs
    3.
    发明授权
    Modification of plant lipids containing PUFAs 有权

    公开(公告)号：US11260095B2

    公开(公告)日：2022-03-01

    申请号：US15526162

    申请日：2015-11-13

    Applicant: BASF PLANT SCIENCE COMPANY GMBH

    Inventor： Toralf Senger ,  Carl Andre

    IPC: A61K36/00 ,  A61K36/31 ,  C12Q1/6895 ,  C12N15/82 ,  C12N9/02 ,  C12N9/00 ,  A61K31/202

    Abstract: The present invention generally is concerned with the modification of plant lipids containing PUFAs. In this context, the invention is particularly concerned with plants and plant materials for such modifications, wherein the plants preferably are oilseed plants. Regarding plant parts, the invention is particularly concerned with seeds of such plants and preferably seeds of oilseed plants. The invention is also concerned with plant positions obtainable or obtained by the modification method of the invention, and with full stuff of feedstuff comprising such liquid compositions.

    METHODS FOR CONVERSION OF THE SUBSTRATE SPECIFICITY OF DESATURASES
    4.
    发明申请
    METHODS FOR CONVERSION OF THE SUBSTRATE SPECIFICITY OF DESATURASES 审中-公开

    公开(公告)号：US20160319249A1

    公开(公告)日：2016-11-03

    申请号：US15105080

    申请日：2014-12-17

    Applicant: BASF PLANT SCIENCE COMPANY GMBH

    Inventor： Toralf Senger ,  Patricia Vrinten ,  Ze Long Lim

    IPC: C12N9/02 ,  C12P7/64

    CPC classification number: C12N9/0071 ,  C07K14/461 ,  C12N9/0083 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y114/19

    Abstract: The present invention relates to methods for the conversion of the substrate specificity of desaturases. Specifically, the present invention pertains to a method for the conversion of the substrate specificity of a Δ5 and/or Δ6 desaturase to the substrate specificity of a Δ4 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ5 and/or Δ6 desaturase and (ii) the Δ4 desaturase; and replacing in the amino acid sequence of the mentioned Δ5 and/or Δ6 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, thereby converting the substrate specificity of the Δ5 and/or Δ6 desaturase to the substrate specificity of the Δ4 desaturase. The present invention further concerns a method for the conversion of the substrate specificity of a Δ4 desaturase to the substrate specificity of a Δ5 and/or Δ6 desaturase, the method comprising: identifying regions and/or amino acid residues which control the substrate specificity of (i) the Δ4 desaturase and (ii) the Δ5 and/or Δ6 desaturase; and replacing in the amino acid sequence of the indicated Δ4 desaturase, the regions and/or amino acid residues which control the substrate specificity of the Δ4 desaturase, by the corresponding regions and/or amino acid residues which control the substrate specificity of the Δ5 and/or Δ6 desaturase, thereby converting the substrate specificity of the Δ4 desaturase to the substrate specificity of the Δ5 and/or Δ6 desaturase. In addition, the invention encompasses desaturases with converted substrate specificity.

    STABILISING FATTY ACID COMPOSITIONS
    6.
    发明公开
    STABILISING FATTY ACID COMPOSITIONS 审中-公开

    公开(公告)号：US20240041961A1

    公开(公告)日：2024-02-08

    申请号：US18051318

    申请日：2022-10-31

    Applicant: BASF PLANT SCIENCE COMPANY GMBH

    Inventor： Toralf Senger ,  Heiko Haertel

    IPC: A61K36/31 ,  C12Q1/6895

    CPC classification number: A61K36/31 ,  C12N15/8247 ,  C12Q1/6895

    Abstract: Assay method, comprising providing a plant capable of expressing a delta-12 desaturase, wherein said delta-12 desaturase has at least 50% total amino acid sequence identity to at least one of the sequences SEQ ID NO. 328 to 336, and/or at least 59% total amino acid sequence similarity to at least one of the sequences SEQ ID NO. 328 to 336, and wherein the plant is also capable of expressing at least one or more enzymes of unsaturated fatty acid metabolism, of which enzymes at least one is capable of using linoleic acid as a substrate, and of which enzymes at least one is supposedly connected to a plant metabolic property, growing the plant, and measuring said plant metabolic property for said plant.

    Enzymes, enzyme components and uses thereof
    8.
    发明授权
    Enzymes, enzyme components and uses thereof 有权

    公开(公告)号：US10119126B2

    公开(公告)日：2018-11-06

    申请号：US15864798

    申请日：2018-01-08

    Applicant: BASF PLANT SCIENCE COMPANY GMBH

    Inventor： Laurent Marty ,  Toralf Senger

    IPC: C12N9/02 ,  C12P7/64

    Abstract: The invention provides nucleic acid molecules which encodes a novel fatty acid desaturase, KCS, KCR and/or LACS from Thraustochytrium aureum and Sphaeroforma arctica. The invention also provides recombinant expression vectors containing the nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., ARA, EPA and DHA and for screening for delta-4 desaturases.

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