公开(公告)号：US09328327B2

公开(公告)日：2016-05-03

申请号：US13696917

申请日：2011-05-10

Applicant: Axel Haverich

Inventor： Axel Haverich

IPC: C12N5/00 ,  B29C67/00

CPC classification number: C12N5/00 ,  B29C64/00 ,  B29C67/0051 ,  B33Y80/00

Abstract: A method for designing or replicating a human or animal organ in the form of a functional model includes providing previously recorded structural-geometric data of the organ or organ part to be replicated, selecting reconstruction materials for the organ or organ part, allocating the structural-geometric data to the individually selected reconstruction materials, and carrying out a layered assembly by the model by successively applying site-selective assembly methods for at least one part of the reconstruction materials on the basis of an associated data set.

Abstract translation: 以功能模型的形式设计或复制人或动物器官的方法包括提供先前记录的要复制的器官或器官部分的结构几何数据，选择器官或器官部分的重建材料，分配结构 - 几何数据到单独选择的重建材料，以及通过对相关数据集合的至少一部分重建材料连续应用场地选择性组装方法，由模型执行分层组装。

公开(公告)号：US08470025B2

公开(公告)日：2013-06-25

申请号：US12514092

申请日：2007-11-09

Applicant: Tim Lenihan ,  Mathias Wilhelmi ,  Axel Haverich

Inventor： Tim Lenihan ,  Mathias Wilhelmi ,  Axel Haverich

IPC: A61F2/24

CPC classification number: A61M29/02 ,  A61B17/0401 ,  A61B17/3468 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/1107 ,  A61M25/0662

Abstract: A method for performing cardiovascular and surgical procedures includes providing a conduit in the form of a graft/canula placed using balloon dilatation catheter and providing a fixing mechanism for the graft/canula. At least one opening is formed through a wall of the heart substantially at the apex. The escape of blood is prevented through the use of the fixing mechanism. Each of these steps is performed while the heart is beating.

Abstract translation: 用于执行心血管和外科手术过程的方法包括提供使用球囊扩张导管放置的移植物/环形物的形式的导管，并提供用于移植物/肠衣的固定机构。 至少一个开口基本上在顶点形成穿过心脏壁。 通过使用固定机构防止血液的逃逸。 这些步骤中的每一个在心脏跳动时进行。

公开(公告)号：US07077801B2

公开(公告)日：2006-07-18

申请号：US10371206

申请日：2003-02-19

Applicant: Axel Haverich

Inventor： Axel Haverich

IPC: A61N1/362

CPC classification number: A61F2/06 ,  A61B17/11 ,  A61B17/32053 ,  A61B2017/00252 ,  A61F2/064 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2475 ,  A61M1/1008 ,  A61M1/1098 ,  A61M1/12

Abstract: Methods and devices are provided for improving cardiac output. The methods involve establishing a fluid communication pathway between the left ventricle and another natural or prosthetic structure. In one method, a conduit is implanted between the left ventricle and the descending aorta where ventricular blood flows from the left ventricle directly into the descending aorta and bypassing the aortic valve. The devices include such conduits and valves for forming the fluid communication pathways.

Abstract translation: 提供了用于改善心输出量的方法和装置。 所述方法涉及在左心室和另一天然或假肢结构之间建立流体连通路径。 在一种方法中，导管植入左心室和下降主动脉之间，心室血液从左心室直接流入降主动脉并绕过主动脉瓣。 这些装置包括用于形成流体连通路径的这种导管和阀。

公开(公告)号：US20050123525A1

公开(公告)日：2005-06-09

申请号：US10986156

申请日：2004-11-12

Applicant: Ulrich Martin ,  Axel Haverich ,  Fred Fandrich

Inventor： Ulrich Martin ,  Axel Haverich ,  Fred Fandrich

IPC: A61K35/12 ,  A61K35/16 ,  A61K35/50 ,  A61K35/54 ,  A61K48/00 ,  C12N5/0735 ,  C12N5/08

CPC classification number: C12N5/0606 ,  A61K35/50 ,  A61K35/54 ,  A61K2035/122 ,  A61K2300/00

Abstract: The present invention relates to a composition comprising embryonic stem cells or haematopoietic stem cells or precursor cells being obtained by differentiation of said embryonic stem cells as well as trophoblasts, trophoblasts precursor and/or placental cell derived from said trophopblasts, all cell types being derived from the same embryonic stem cell origin. Further, the present invention relates to the induction of immune tolerance in an Individual as well as methods for cell, tissue and organ transplantation. The composition according to the present invention may be used in the treatment or therapy of transplantation or gene therapy or in the field of tissue engineering.

Abstract translation: 本发明涉及包含胚胎干细胞或造血干细胞或前体细胞的组合物，所述胚胎干细胞或造血干细胞或前体细胞通过分化所述胚胎干细胞以及滋养细胞，滋养细胞前体和/或源自所述嗜酸性粒细胞的胎盘细胞获得，所有细胞类型来源于 相同的胚胎干细胞起源。 此外，本发明涉及个体中免疫耐受的诱导以及细胞，组织和器官移植的方法。 根据本发明的组合物可用于移植或基因治疗或组织工程领域的治疗或治疗。

公开(公告)号：US09655931B2

公开(公告)日：2017-05-23

申请号：US14344344

申请日：2012-09-13

Applicant: Axel Haverich ,  Thomas Aper ,  Mathias Wilhelmi

Inventor： Axel Haverich ,  Thomas Aper ,  Mathias Wilhelmi

IPC: A61K35/44 ,  A61K35/33 ,  A61K35/34 ,  A61K35/12

CPC classification number: A61K35/44 ,  A61K35/12 ,  A61K35/33 ,  A61K35/34 ,  A61K2300/00

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

公开(公告)号：US20130059280A1

公开(公告)日：2013-03-07

申请号：US13696917

申请日：2011-05-10

Applicant: Axel Haverich

Inventor： Axel Haverich

IPC: G09B23/28 ,  B29C35/08 ,  B29C67/00

CPC classification number: C12N5/00 ,  B29C64/00 ,  B29C67/0051 ,  B33Y80/00

Abstract: A method for designing or replicating a human or animal organ in the form of a functional model includes providing previously recorded structural-geometric data of the organ or organ part to be replicated, selecting reconstruction materials for the organ or organ part, allocating the structural-geomtric data to the individually selected reconstruction materials, and carrying out a layered assembly by the model by successively applying site-selective assembly methods for at least one part of the reconstruction materials on the basis of an associated data set.

Abstract translation: 以功能模型的形式设计或复制人或动物器官的方法包括提供先前记录的要复制的器官或器官部分的结构几何数据，选择器官或器官部分的重建材料，分配结构 - 通过对相关数据集合的至少一部分重建材料连续地应用场地选择性组装方法，通过模型执行分层组装。

公开(公告)号：US07732125B2

公开(公告)日：2010-06-08

申请号：US10467878

申请日：2002-02-13

Applicant: Axel Haverich ,  Heike Mertsching

Inventor： Axel Haverich ,  Heike Mertsching

IPC: A01N1/00 ,  A61F2/06

CPC classification number: A61L27/3683 ,  A61L27/3625 ,  A61L27/3629 ,  A61L27/38 ,  Y10S623/916

Abstract: The invention relates to a bioartificial primarily vascularized tissue matrix, a bioartificial primarily vascularized tissue, a method for the production thereof and the use of the same. Said tissue matrix and bioartificial primarily vascularized tissue are obtained by preparing the necessary natural tissue, conserving at least one vessel.

Abstract translation: 本发明涉及生物人造主要血管化组织基质，生物人造主要血管化组织，其生产方法及其用途。 所述组织基质和生物人造主要血管化组织通过制备必需的天然组织获得，保存至少一个血管。

公开(公告)号：US20140341862A1

公开(公告)日：2014-11-20

申请号：US14344344

申请日：2012-09-13

Applicant: Axel Haverich ,  Thomas Aper ,  Mathias Wilhelmi

Inventor： Axel Haverich ,  Thomas Aper ,  Mathias Wilhelmi

IPC: A61K35/44

CPC classification number: A61K35/44 ,  A61K35/12 ,  A61K35/33 ,  A61K35/34 ,  A61K2300/00

Abstract: The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (EPC) which have not been passaged multiple times and have a content of EOEC (early outgrowth endothelial progenitor cells) and LOEC (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in the form of living cells, seeded onto a matrix or introduced into a matrix in order to yield the tissue construct following further treatment steps. The matrix is preferably a protein preparation, more particularly a fibrinogen preparation. Both the cells and the fibrinogen preparation can be obtained from a single blood sample from a patient. Apart from the preparation of bypass materials, prosthetic vascular graft, tissue patches, conduits and the like, the EOEC-containing EPC culture or suspension is suitable as means for cell transplantation.

Abstract translation: 制备用于医学目的的组织构建体的方法使用尚未多次传代并具有EOEC（早期内生内皮祖细胞）和LOEC（晚期内生内皮祖细胞）含量的内皮祖细胞（EPC）。 这些细胞和成纤维细胞和/或肌肉细胞， 成肌细胞，肌成纤维细胞，平滑肌细胞或其祖细胞以活细胞的形式接种在基质上或引入基质中，以便在进一步的治疗步骤之后产生组织构建体。 该基质优选是蛋白质制剂，更特别是纤维蛋白原制剂。 细胞和纤维蛋白原制剂都可以从患者的单一血液样品获得。 除了旁路材料，假体血管移植物，组织块，导管等的制备之外，含有EOEC的EPC培养物或悬浮液适合作为细胞移植的手段。

公开(公告)号：US07766811B2

公开(公告)日：2010-08-03

申请号：US10545993

申请日：2004-02-18

Applicant: Axel Haverich

Inventor： Axel Haverich

IPC: A61N1/362

CPC classification number: A61F2/06 ,  A61B17/11 ,  A61B17/32053 ,  A61B2017/00252 ,  A61F2/064 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2475 ,  A61M1/1008 ,  A61M1/1098 ,  A61M1/12

Abstract: Methods and devices are provided for improving cardiac output. The methods involve establishing a fluid communication pathway between the left ventricle and another natural or prosthetic structure. In one method, a conduit is implanted between the left ventricle and the descending aorta where ventricular blood flows from the left ventricle directly into the descending aorta and bypassing the aortic valve. The devices include such conduits and valves for forming the fluid communication pathways.

Abstract translation: 提供了用于改善心输出量的方法和装置。 所述方法涉及在左心室和另一天然或假肢结构之间建立流体连通路径。 在一种方法中，导管植入左心室和下降主动脉之间，心室血液从左心室直接流入降主动脉并绕过主动脉瓣。 这些装置包括用于形成流体连通路径的这种导管和阀。

公开(公告)号：US20100114306A1

公开(公告)日：2010-05-06

申请号：US12514092

申请日：2007-11-09

Applicant: Tim Lenihan ,  Mathias Wilhelmi ,  Axel Haverich

Inventor： Tim Lenihan ,  Mathias Wilhelmi ,  Axel Haverich

IPC: A61M31/00

CPC classification number: A61M29/02 ,  A61B17/0401 ,  A61B17/3468 ,  A61B2017/00243 ,  A61B2017/0409 ,  A61B2017/1107 ,  A61M25/0662

Abstract: A method for performing cardiovascular and surgical procedures includes providing a conduit in the form of a graft/canula placed using balloon dilatation catheter and providing a fixing mechanism for the graft/canula. At least one opening is formed through a wall of the heart substantially at the apex. The escape of blood is prevented through the use of the fixing mechanism. Each of these steps is performed while the heart is beating.

Abstract translation: 用于执行心血管和外科手术过程的方法包括提供使用球囊扩张导管放置的移植物/环形物的形式的导管，并提供用于移植物/肠衣的固定机构。 至少一个开口基本上在顶点形成穿过心脏壁。 通过使用固定机构防止血液的逃逸。 这些步骤中的每一个在心脏跳动时进行。