知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.016 秒)

    Methods and compounds
    1.
    发明授权
    Methods and compounds 失效
    方法和化合物

    公开(公告)号：US5190946A

    公开(公告)日：1993-03-02

    申请号：US654154

    申请日：1991-02-12

    申请人： Avner Ramu ,  Karel Valter

    发明人： Avner Ramu ,  Karel Valter

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/165 ,  A61K31/22 ,  A61K31/235 ,  A61K31/475 ,  A61K31/495 ,  A61K31/675 ,  A61P23/02 ,  A61P25/02 ,  A61P35/00 ,  C07C217/06 ,  C07C219/10 ,  C07C219/14 ,  C07C229/04 ,  C07C229/34 ,  C07C233/36 ,  C07C233/78 ,  C07C235/10 ,  C07C235/50 ,  C07C237/10 ,  C07C237/20 ,  C07C237/34 ,  C07D295/088 ,  C07D295/108 ,  C07D295/13 ,  C07D295/14 ,  C07D295/15 ,  C07D295/18 ,  C07D295/185

    CPC分类号： C07D295/185 ,  A61K31/13 ,  A61K31/135 ,  A61K31/22 ,  A61K31/475 ,  A61K31/495 ,  A61K31/675 ,  A61K31/70 ,  C07C219/10 ,  C07D295/088 ,  C07D295/108 ,  C07D295/13 ,  C07D295/15 ,  C07C2101/14

    摘要： Compounds of formula ##STR1## wherein R and R.sup.3, which may be the same or different, each is hydrogen, an alkyl group containing 1 to 5 carbon atoms, or an optionally substituted aryl or aralkyl group, substituents being selected from the group consisting of halogen, alkoxy and alkyl groups containing 1 to 5 carbon atoms, said alkyl groups in turn being optionally halo-substituted; R.sup.1 and R.sup.2, which may be the same or different, each is hydrogen, an alkyl group containing 1 to 5 carbon atoms, or an optionally substituted aryl or aralkyl group, substituents being as indicated above or R.sup.1 and R.sup.2 taken together are an alkylene group containing 2 or 3 carbon atoms; m and p, which may be the same or different each is a number from 0 to 3; n is the number 2 or 3; and X is a group of the formula R.sub.x.sup.4 --CO--, R.sub.x.sup.4 --COO--, R.sub.x.sup.4 --CONH--, R.sub.x.sup.4 --NHCO--, or R.sub.x.sup.4 --O-- and Y is a group of formula R.sub.y.sup.4 --CO--, R.sub.y.sup.4 --COO--, R.sub.y.sup.4 --CONH--, R.sub.y.sup.4 --NHCO--, or R.sub.y.sup.4 --O-- which R.sub.y.sup.4 and R.sub.x.sup.4, which may be the same of different, each is an optionally substituted aryl, aralkyl or aryloxyalkyl group, substitutents being as indicated above, and the alkyl moiety in the aralkyl and aryloxyalkyl groups containing 1 to 5 carbon atoms and can be optionally substituted by a cyloalkyl group containing 3 to 8 carbon atoms; and physiologically acceptable acid addition salts thereof, have been found to be active in restoring drug-sensitivity to cancer cells that have become multidrug-resistant. They can, therefore, be used as adjuvants in oncology, and they can be administered simultaneously, separately or at intervals in combination with one or more conventional anti-cancer agents for treating malignant tumors and corresponding metastases.Compounds and salts which have not been previously described in British Patent Specification No. 883013 as well as their preparation and pharmaceutical compositions containing them are also disclosed.

    Implantable bladder fullness sensor
    4.
    发明授权
    Implantable bladder fullness sensor 有权

    公开(公告)号：US10405789B2

    公开(公告)日：2019-09-10

    申请号：US15643567

    申请日：2017-07-07

    申请人： Avner Ramu ,  Nehemia Hampel

    发明人： Avner Ramu ,  Nehemia Hampel

    IPC分类号： A61B5/20 ,  A61B5/00 ,  A61B5/07 ,  A61N1/36

    摘要： An apparatus for determining the volume of urine in a human bladder is described. The apparatus uses light to determine the length of a flexible tube attached vertically to the outside of the bladder, and converts the length into a fullness value that is transmitted to an external device that notifies a user about the state of the bladder.

    Ameliorating periodontitis by local treatment with warfarin and/or other vitamin K oxide reductase inhibitors
    5.
    发明授权
    Ameliorating periodontitis by local treatment with warfarin and/or other vitamin K oxide reductase inhibitors 有权

    公开(公告)号：US10383845B2

    公开(公告)日：2019-08-20

    申请号：US15970933

    申请日：2018-05-04

    申请人： Avner Ramu

    发明人： Avner Ramu

    IPC分类号： A61K31/37 ,  A61Q11/00 ,  A61K8/49 ,  A61K9/20 ,  A61K9/68

    摘要： A new indication for the Warfarin family of drugs is described. In patients suffering from chronic periodontitis, continued systemic medication with Warfarin causes a significant reduction in their chronic periodontitis, including reduction in the frequency and severity of gingival inflammation occurrences, and significant decrease in the buildup of dental plaque and tartar. Delivery of Warfarin or its analogs directly to the oral fluid using toothpaste, mouthwash, chewing gum, dental floss, toothbrush, pill, and other forms are described to reduce chronic periodontitis, dental plaque, and dental tartar.

    Ameliorating Periodontitis by Local Treatment with Warfarin and/or Other Vitamin K Oxide Reductase Inhibitors
    6.
    发明申请
    Ameliorating Periodontitis by Local Treatment with Warfarin and/or Other Vitamin K Oxide Reductase Inhibitors 审中-公开

    公开(公告)号：US20190350900A1

    公开(公告)日：2019-11-21

    申请号：US16531018

    申请日：2019-08-03

    申请人： Avner Ramu

    发明人： Avner Ramu

    IPC分类号： A61K31/37 ,  A61K9/68 ,  A61K8/49 ,  A61Q11/00 ,  A61K9/20

    摘要： A new indication for the Warfarin family of drugs is described. In patients suffering from chronic periodontitis, continued systemic medication with Warfarin causes a significant reduction in their chronic periodontitis, including reduction in the frequency and severity of gingival inflammation occurrences, and significant decrease in the buildup of dental plaque and tartar. Delivery of Warfarin or its analogs directly to the oral fluid using toothpaste, mouthwash, chewing gum, dental floss, toothbrush, pill, and other forms are described to reduce chronic periodontitis, dental plaque, and dental tartar.

    Formulations of vesicant drugs and methods of use thereof
    8.
    发明授权
    Formulations of vesicant drugs and methods of use thereof 失效
    泡沫药物的制剂及其使用方法

    公开(公告)号：US5780446A

    公开(公告)日：1998-07-14

    申请号：US700742

    申请日：1996-07-09

    申请人： Avner Ramu

    发明人： Avner Ramu

    IPC分类号： A61K31/525 ,  A61K31/675 ,  A61K45/06 ,  A61K31/70

    CPC分类号： A61K31/7048 ,  A61K31/525 ,  A61K31/675 ,  A61K45/06

    摘要： The present invention relates to methods of treating, as well as preventing extravasation injury. In particular, the present invention pertains to photochemotherapeutic methods of prophylaxis and/or treatment of extravasation injury induced by vesicant antineoplastic drugs and other pharmaceutical formulations. In accordance with the present invention, extravasation injury is prevented or minimized by the coadministration of photoinactivation inducing compounds in a formulation comprising a vesicant antineoplastic or other pharmaceutical formulation, and subsequently exposing the injection or infusion site to photoexciting light.

    摘要翻译： 本发明涉及治疗以及预防外渗损伤的方法。 特别地，本发明涉及预防和/或治疗由引发抗肿瘤药物和其它药物制剂诱发的外渗损伤的光化学治疗方法。 根据本发明，通过在包含发泡抗肿瘤剂或其它药物制剂的制剂中共同施用光激活诱导化合物，随后将注射或注射部位暴露于光激发光，来防止或最小化外渗损伤。