A new indication for the Warfarin family of drugs is described. In patients suffering from chronic periodontitis, continued systemic medication with Warfarin causes a significant reduction in their chronic periodontitis, including reduction in the frequency and severity of gingival inflammation occurrences, and significant decrease in the buildup of dental plaque and tartar. Delivery of Warfarin or its analogs directly to the oral fluid using toothpaste, mouthwash, chewing gum, dental floss, toothbrush, pill, and other forms are described to reduce chronic periodontitis, dental plaque, and dental tartar.