公开(公告)号：US20220257800A1

公开(公告)日：2022-08-18

申请号：US17302453

申请日：2021-05-03

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： A61K49/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/65

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).

公开(公告)号：US09504763B2

公开(公告)日：2016-11-29

申请号：US15132773

申请日：2016-04-19

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： A61K38/00 ,  A61K49/00 ,  C07K7/08 ,  G01N33/574 ,  G01N33/58 ,  G01N21/64

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0056 ,  C07K14/435 ,  G01N21/6428 ,  G01N33/574 ,  G01N33/582 ,  G01N2021/6432 ,  G01N2021/6439

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

公开(公告)号：US09840537B2

公开(公告)日：2017-12-12

申请号：US15295482

申请日：2016-10-17

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： A61K38/00 ,  C07K7/08 ,  A61K49/00 ,  C07K14/435 ,  G01N21/64 ,  G01N33/574 ,  G01N33/58

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0056 ,  C07K14/435 ,  G01N21/6428 ,  G01N33/574 ,  G01N33/582 ,  G01N2021/6432 ,  G01N2021/6439

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

公开(公告)号：US09371367B1

公开(公告)日：2016-06-21

申请号：US15006832

申请日：2016-01-26

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： A61K38/00 ,  C07K14/435 ,  A61K49/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0056 ,  C07K14/435 ,  G01N21/6428 ,  G01N33/574 ,  G01N33/582 ,  G01N2021/6432 ,  G01N2021/6439

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

公开(公告)号：US20160152670A1

公开(公告)日：2016-06-02

申请号：US15006832

申请日：2016-01-26

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： C07K14/435 ,  A61K49/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0056 ,  C07K14/435 ,  G01N21/6428 ,  G01N33/574 ,  G01N33/582 ,  G01N2021/6432 ,  G01N2021/6439

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

公开(公告)号：US20210268120A1

公开(公告)日：2021-09-02

申请号：US17249006

申请日：2021-02-17

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu ,  Marcel Miampamba

IPC分类号： A61K47/64 ,  A61K49/00

摘要： Described herein are methods and compositions for nerve delivery molecules that carry imaging cargo or therapeutic cargo to the neurons or nerves.

公开(公告)号：US10570178B2

公开(公告)日：2020-02-25

申请号：US16228488

申请日：2018-12-20

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： C07K7/08 ,  A61K49/00 ,  C07K14/435 ,  G01N21/64 ,  G01N33/574 ,  G01N33/58 ,  A61K38/00

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

公开(公告)号：US09353154B2

公开(公告)日：2016-05-31

申请号：US14736194

申请日：2015-06-10

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： C07K7/06 ,  A61K49/00 ,  G09F13/04 ,  G09F13/18 ,  G09F13/22 ,  G09F13/44

CPC分类号： C07K7/06 ,  A61K49/0056 ,  G09F13/04 ,  G09F13/18 ,  G09F13/22 ,  G09F13/44 ,  G09F2013/1863

摘要： The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.

公开(公告)号：US11052160B2

公开(公告)日：2021-07-06

申请号：US16264296

申请日：2019-01-31

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu

IPC分类号： A61K49/00 ,  A61K49/14 ,  A61K47/60 ,  A61K47/64 ,  A61K47/65

摘要： Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).

公开(公告)号：US10994017B2

公开(公告)日：2021-05-04

申请号：US16466259

申请日：2017-12-01

申请人： Avelas Biosciences, Inc.

发明人： Jesus Gonzalez ,  Junjie Liu ,  Marcel Miampamba

IPC分类号： A61K47/64 ,  A61K49/00

摘要： Described herein are methods and compositions for nerve delivery molecules that carry imaging cargo or therapeutic cargo to the neurons or nerves.