SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
    5.
    发明申请
    SELECTIVE DELIVERY MOLECULES AND METHODS OF USE 有权
    选择性递送分子和使用方法

    公开(公告)号:US20150359908A1

    公开(公告)日:2015-12-17

    申请号:US14764681

    申请日:2014-01-30

    IPC分类号: A61K49/00

    摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).

    摘要翻译: 本文公开了选择性递送分子,其包含:(a)有效抑制或阻止摄入细胞或组织滞留的酸性序列(部分A),(b)分子转运或组织保留序列(部分B),和 (c)部分A和部分B之间的接头,和(d)货物部分(部分DA和DB)。

    COMPOSITIONS FOR LABELING NERVES AND METHODS OF USE
    6.
    发明申请
    COMPOSITIONS FOR LABELING NERVES AND METHODS OF USE 有权
    用于标记神经的组合物和使用方法

    公开(公告)号:US20150353604A1

    公开(公告)日:2015-12-10

    申请号:US14736194

    申请日:2015-06-10

    IPC分类号: C07K7/06 A61K49/00

    摘要: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.

    摘要翻译: 本发明提供了通过施用与神经元或神经相关联(例如,特异性结合)的荧光标记肽来指导手术期间神经元或神经保存的方法。 本发明还提供与(例如,特异性结合)神经元或神经及其组合物结合的荧光标记肽或适体的靶向分子。