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公开(公告)号:US20220257800A1
公开(公告)日:2022-08-18
申请号:US17302453
申请日:2021-05-03
发明人: Jesus Gonzalez , Junjie Liu
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).
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公开(公告)号:US20200061200A1
公开(公告)日:2020-02-27
申请号:US16466259
申请日:2017-12-01
发明人: Jesus GONZALEZ , Junjie LIU , Marcel MIAMPAMBA
摘要: Described herein are methods and compositions for nerve delivery molecules that carry imaging cargo or therapeutic cargo to the neurons or nerves.
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公开(公告)号:US20190119327A1
公开(公告)日:2019-04-25
申请号:US16228488
申请日:2018-12-20
发明人: Jesus GONZALEZ , Junjie LIU
IPC分类号: C07K7/08 , C07K14/435 , A61K49/00 , G01N33/58 , G01N33/574 , G01N21/64
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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公开(公告)号:US09504763B2
公开(公告)日:2016-11-29
申请号:US15132773
申请日:2016-04-19
发明人: Jesus Gonzalez , Junjie Liu
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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公开(公告)号:US20150359908A1
公开(公告)日:2015-12-17
申请号:US14764681
申请日:2014-01-30
发明人: Jesus GONZALEZ , Junjie LIU
IPC分类号: A61K49/00
CPC分类号: A61K49/0056 , A61K47/60 , A61K47/64 , A61K47/65 , A61K49/0032 , A61K49/0054
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or tissue retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) cargo moieties (portion DA and DB).
摘要翻译: 本文公开了选择性递送分子,其包含:(a)有效抑制或阻止摄入细胞或组织滞留的酸性序列(部分A),(b)分子转运或组织保留序列(部分B),和 (c)部分A和部分B之间的接头,和(d)货物部分(部分DA和DB)。
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公开(公告)号:US20150353604A1
公开(公告)日:2015-12-10
申请号:US14736194
申请日:2015-06-10
发明人: Jesus GONZALEZ , Junjie LIU
CPC分类号: C07K7/06 , A61K49/0056 , G09F13/04 , G09F13/18 , G09F13/22 , G09F13/44 , G09F2013/1863
摘要: The present invention provides methods for guiding preservation of neurons or nerves during surgery by administering a fluorescently-labeled peptide that associates with (e.g., specifically binds to) the neurons or nerves. The invention further provides targeting molecules of fluorescently-labeled peptides or aptamers that associate with (e.g., specifically bind to) neurons or nerves and for compositions thereof.
摘要翻译: 本发明提供了通过施用与神经元或神经相关联(例如,特异性结合)的荧光标记肽来指导手术期间神经元或神经保存的方法。 本发明还提供与(例如,特异性结合)神经元或神经及其组合物结合的荧光标记肽或适体的靶向分子。
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公开(公告)号:US20180057536A1
公开(公告)日:2018-03-01
申请号:US15806246
申请日:2017-11-07
发明人: Jesus GONZALEZ , Junjie LIU
IPC分类号: C07K7/08 , C07K14/435 , A61K49/00 , G01N33/58 , G01N33/574 , G01N21/64 , A61K38/00
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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公开(公告)号:US09840537B2
公开(公告)日:2017-12-12
申请号:US15295482
申请日:2016-10-17
发明人: Jesus Gonzalez , Junjie Liu
IPC分类号: A61K38/00 , C07K7/08 , A61K49/00 , C07K14/435 , G01N21/64 , G01N33/574 , G01N33/58
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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公开(公告)号:US09371367B1
公开(公告)日:2016-06-21
申请号:US15006832
申请日:2016-01-26
发明人: Jesus Gonzalez , Junjie Liu
IPC分类号: A61K38/00 , C07K14/435 , A61K49/00
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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公开(公告)号:US20160152670A1
公开(公告)日:2016-06-02
申请号:US15006832
申请日:2016-01-26
发明人: Jesus Gonzalez , Junjie Liu
IPC分类号: C07K14/435 , A61K49/00
CPC分类号: C07K7/08 , A61K38/00 , A61K49/0021 , A61K49/0032 , A61K49/0034 , A61K49/0054 , A61K49/0056 , C07K14/435 , G01N21/6428 , G01N33/574 , G01N33/582 , G01N2021/6432 , G01N2021/6439
摘要: Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.
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