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公开(公告)号：US20220226326A1
公开(公告)日：2022-07-21
申请号：US17409644
申请日：2021-08-23
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlachter , Anna L. Leivers , Jun Liang , Brian Safina , Birong Zhang , Christine Chabot , Steven Do
IPC: A61K31/517 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D239/70 , C07D413/12 , C07D407/12
Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：US20180334441A1
公开(公告)日：2018-11-22
申请号：US16009030
申请日：2018-06-14
Applicant: Array Biopharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07F9/6539 , C07F9/201 , C07D417/12 , C07D417/06 , C07D271/107 , C07D413/12 , C07D413/06 , C07D413/04 , C07D401/12 , C07D417/04
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号：US20160368916A1
公开(公告)日：2016-12-22
申请号：US14988521
申请日：2016-01-05
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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4.发明申请公开(公告)号：US20140349996A1
公开(公告)日：2014-11-27
申请号：US14456670
申请日：2014-08-11
Applicant: Array BioPharma Inc. , Genentech, Inc.
Inventor： Ian S. Mitchell , James F. Blake , Rui Xu , Nicholas C. Kallan , Dengming Xiao , Keith Lee Spencer , Josef R. Bencsik , Eli M. Wallace , Stephen T. Schlacter , Anna L. Banka , Jun Liang , Brian Safina , Jun Li , Christine Chabot
IPC: C07D409/14 , A61K31/517 , A61K45/06 , C07D239/70 , C07D409/12 , C07D401/14 , C07D403/12 , C07D405/12 , A61K31/5377 , C07D403/04 , C07D403/14
CPC classification number: C07D409/14 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/70 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供了式I化合物，包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：US20170066733A1
公开(公告)日：2017-03-09
申请号：US15357613
申请日：2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/12 , C07F9/6539 , C07D417/06
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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Patent Agency Ranking
公开(公告)号：US09346805B2
公开(公告)日：2016-05-24
申请号：US13676963
申请日：2012-11-14
Applicant: Array BioPharma Inc.
Inventor： Anna Banka , Josef R. Bencsik , James F. Blake , Kin Chiu Fong , Martin F. Hentemann , Ian S. Mitchell , Douglas McCord Sammond , Tony P. Tang , Eli M. Wallace , Rui Xu , James Graham
IPC: C07D471/10 , C07D487/10
CPC classification number: C07D471/10 , C07D487/10
Abstract: The present invention provides compounds of Formula I including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.
Abstract translation: 本发明提供式I化合物，其包括互变异构体，拆分的对映异构体，拆分的非对映体，溶剂合物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和治疗Akt介导的疾病例如过度增殖性疾病如癌症的方法。
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公开(公告)号：US09221841B2
公开(公告)日：2015-12-29
申请号：US14663286
申请日：2015-03-19
Applicant: Array BioPharma Inc.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC: C07D417/04 , C07D417/14 , C07D285/12 , C07D471/04 , C07D419/04 , C07D487/04 , C07D513/04 , C07D495/04 , C07F9/6539 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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8.发明授权Intermediates for the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives 有权用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物的中间体公开(公告)号：US09079890B2
公开(公告)日：2015-07-14
申请号：US14494430
申请日：2014-09-23
Applicant: Array BioPharma Inc.
Inventor： Thomas Daniel Aicher , Steven Armen Boyd , Mark Joseph Chicarelli , Kevin Ronald Condroski , Jay Bradford Fell , John P. Fischer , Indrani W. Gunawardana , Ronald Jay Hinklin , Ajay Singh , Timothy M. Turner , Eli M. Wallace
IPC: C07D417/00 , C07D401/14 , C07D417/14 , C07D213/75 , C07D417/12 , C07D401/12
CPC classification number: C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
Abstract: Provided are intermediates having the formulas wherein R2, R3, and L are as defined in the specification, which are useful in the preparation of pyridin-2-yl-amino-1,2,4-thiadiazole derivatives.
Abstract translation: 提供具有下式的中间体其中R2，R3和L如说明书中所定义，其可用于制备吡啶-2-基 - 氨基-1,2,4-噻二唑衍生物。
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公开(公告)号：US08981085B2
公开(公告)日：2015-03-17
申请号：US14271129
申请日：2014-05-06
Applicant: Array BioPharma Inc.
Inventor： Yvan Le Huerou , James F. Blake , Indrani W. Gunawardana , Peter J. Mohr , Eli M. Wallace , Bin Wang , Mark Joseph Chicarelli , Michael Lyon
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D401/06 , C07D519/00
Abstract: Compounds of Formula I are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Abstract translation: 式I的化合物可用于抑制CHK1和/或CHK2。 公开了使用式I化合物及其立体异构体及其药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US10017482B2
公开(公告)日：2018-07-10
申请号：US15357613
申请日：2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor： Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/04 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D401/12 , C07D417/12 , C07F9/201 , C07F9/6539
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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