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公开(公告)号:US20180334441A1
公开(公告)日:2018-11-22
申请号:US16009030
申请日:2018-06-14
Applicant: Array Biopharma Inc.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07F9/6539 , C07F9/201 , C07D417/12 , C07D417/06 , C07D271/107 , C07D413/12 , C07D413/06 , C07D413/04 , C07D401/12 , C07D417/04
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号:US09102639B2
公开(公告)日:2015-08-11
申请号:US14099276
申请日:2013-12-06
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D401/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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3.MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权
Title translation: MITOTIC KINESIN INHIBITORS及其使用方法公开(公告)号:US20170066733A1
公开(公告)日:2017-03-09
申请号:US15357613
申请日:2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/12 , C07F9/6539 , C07D417/06
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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4.
公开(公告)号:US09221841B2
公开(公告)日:2015-12-29
申请号:US14663286
申请日:2015-03-19
Applicant: Array BioPharma Inc.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC: C07D417/04 , C07D417/14 , C07D285/12 , C07D471/04 , C07D419/04 , C07D487/04 , C07D513/04 , C07D495/04 , C07F9/6539 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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5.MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权
Title translation: MITOTIC KINESIN INHIBITORS及其使用方法公开(公告)号:US20150210658A1
公开(公告)日:2015-07-30
申请号:US14679866
申请日:2015-04-06
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/12 , C07F9/201 , C07D417/06
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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6.MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF 有权
Title translation: MITOTIC KINESIN INHIBTORS及其使用方法公开(公告)号:US20150191490A1
公开(公告)日:2015-07-09
申请号:US14663286
申请日:2015-03-19
Applicant: Array BioPharma Inc.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk Delisle , Walter C. Voegtli
IPC: C07D513/04 , C07D285/12 , C07D417/04 , C07D419/04 , C07D497/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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7.MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权
Title translation: MITOTIC KINESIN INHIBITORS及其使用方法公开(公告)号:US20140094603A1
公开(公告)日:2014-04-03
申请号:US14099276
申请日:2013-12-06
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D401/12
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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8.MITOTIC KINESIN INHIBTORS AND METHODS OF USE THEREOF 审中-公开
Title translation: MITOTIC KINESIN INHIBTORS及其使用方法公开(公告)号:US20140018399A1
公开(公告)日:2014-01-16
申请号:US14031958
申请日:2013-09-19
Applicant: Array BioPharma Inc.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Shelley Allen , Ellen Laird , Joseph P. Lyssikatos , John E. Robinson , Christopher P. Corrette , Robert Kirk DeLisle , Walter C. Voegtli
IPC: C07D285/12 , C07D417/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂,特别是KSP,以及制备这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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公开(公告)号:US10017482B2
公开(公告)日:2018-07-10
申请号:US15357613
申请日:2016-11-21
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen Laird , John Robinson , Shelley Allen
IPC: C07D285/12 , C07D417/04 , C07D271/107 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/06 , C07D401/12 , C07D417/12 , C07F9/201 , C07F9/6539
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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公开(公告)号:US09499503B2
公开(公告)日:2016-11-22
申请号:US14679866
申请日:2015-04-06
Applicant: ARRAY BIOPHARMA INC.
Inventor: Jeremy Hans , Eli M. Wallace , Qian Zhao , Joseph P. Lyssikatos , Thomas D. Aicher , Ellen R. Laird , John Robinson , Shelley Allen
IPC: C07D271/107 , C07D413/04 , C07D417/04 , C07D285/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D401/12 , C07D417/12 , C07F9/201
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors.
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